 | | Vol. 11.23 – 16 June, 2020 |
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| Researchers showed that Bacille-Calmette-Guérin vaccination in healthy human volunteers induced a persistent transcriptional program connected to myeloid cell development and function within the hematopoietic stem and progenitor cell compartment in the bone marrow.
[Cell Host & Microbe] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators developed a conditionally inducible Cdx2 mouse model to determine the effects of in vivo, inducible Cdx2 expression in hematopoietic stem and progenitor cells.
[Nature Communications] |
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| The authors showed that the transcription factor ETS Related Gene (Erg) was essential for early B lymphoid differentiation. Erg initiated a transcriptional network involving the B cell lineage defining genes, Ebf1 and Pax5, which directly promoted expression of key genes involved in V(D)J recombination and formation of the B cell receptor.
[Nature Communications] |
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| Scientists showed that nuclear receptor binding SET domain protein 1 knockdown alters erythroid clonogenic growth of human CD34+ hematopoietic cells.
[Nature Communications] |
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| Researchers analyzed the relevance of cytofluorimetric assessment of the percentage of CD34-positive blood cells that had a positive CXCR4 surface expression in a large cohort of subjects with myeloproliferative neoplasms.
[Leukemia] |
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| Scientists generated a mouse model with hematopoietic cell-specific knockout of Hopx (Hopx−/−). In young Hopx−/− mice, the HSCs showed decreased reconstitution ability after serial transplantation.
[Oncogene] |
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| The authors established an efficient CRISPR/Cas9-based mixed lineage leukemia rearrangements model in hematopoietic stem and progenitor cells (HSPCs) derived from human cord blood (huCB) and faithfully mimicked the underlying biology of the disease. They applied this model to HSPCs from adult bone marrow to investigate the impact of the cell of origin and fusion partner on disease development.
[Cancers] |
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| Investigators developed a risk score to predict event-free survival after allogeneic hematopoietic cell transplantation for sickle cell disease.
[Blood] |
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| Targeted sequencing of the stem cell product from 629 multiple myeloma patients treated by autologous stem cell transplant at the Dana-Farber Cancer Institute detected clonal hematopoiesis of indeterminate potential in 136/629 patients.
[Nature Communications] |
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| The authors discuss the role of miRs in the regulation of HSC self-renewal and differentiation throughout life and its implications for future research.
[Mechanisms of Ageing and Development] |
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| Partner Therapeutics announced the enrollment of the first patient dosed in a Phase II investigator-initiated study evaluating the efficacy and safety of Leukine® in T cell replete HLA-mismatched haploidentical stem cell transplant recipients who are receiving post-transplant cyclophosphamide.
[Partner Therapeutics, Inc.] |
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| Curis, Inc. announced that the FDA has cleared its Investigational New Drug (IND) application for CI-8993, the first-in-class monoclonal anti-VISTA antibody.
[Curis, Inc.] |
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| China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected.
[Nature News] |
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| The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider] |
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| 2020-08-17 – 2020-08-19
Virtual |
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| | Columbia University – New York, New York, United States |
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| | University of Illinois at Chicago – Chicago, Illinois, United States |
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| | Karolinska Institutet – Huddinge, Sweden |
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| | Karolinska Institutet – Huddinge, Sweden |
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| | University of Bristol – Bristol, United Kingdom |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Heidelberg University Hospital – Heidelberg, Germany |
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| | University of Maryland – Baltimore, Maryland, United States |
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| | Josep Carreras Leukaemia Research Institute – Barcelona, Spain |
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| | NIH National Heart, Lung, and Blood Institute – Bethesda, Maryland, United States |
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| | University of Bern – Bern, Switzerland |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | UC Davis School of Medicine – Davis, California, United States |
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| | UC Davis School of Medicine – Davis, California, United States |
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