Hematopoiesis News Volume 11.25 | Jun 30 2020

    0
    21







    2020-30-06 | HN 11.25


    Hematopoiesis News by STEMCELL Technologies
    Vol. 11.25 – 30 June, 2020
    TOP STORY

    Monogenic and Polygenic Inheritance Become Instruments for Clonal Selection

    The authors identified 19,632 autosomal mosaic chromosomal alterations and analyzed these for relationships to inherited genetic variation. They found 52 inherited, rare, large-effect coding or splice variants in seven genes that were associated with greatly increased vulnerability to clonal hematopoiesis with specific acquired copy-neutral loss of heterozygosity mutations.
    [Nature]

    Abstract

    Guide to everything you need to know about cell separation.
    PUBLICATIONSRanked by the impact factor of the journal

    Chromosomal Alterations among Age-Related Hematopoietic Clones in Japan

    Scientists describe shared and population-specific patterns of genomic mutations and clonal selection in hematopoietic cells on the basis of 33,250 autosomal mosaic chromosomal alterations that they detected in 179,417 Japanese participants in the BioBank Japan cohort and compared with analogous data from the UK Biobank.
    [Nature]

    Abstract

    Efficient Gene Editing of Human Long-Term Hematopoietic Stem Cells Validated by Clonal Tracking

    Investigators applied a barcoding strategy to clonal tracking of edited cells and showed that editing activated p53, which substantially shrank the hematopoietic stem cell clonal repertoire in hematochimeric mice, although engrafted edited clones preserved multilineage and self-renewing capacity.
    [Nature Biotechnology]

    Abstract

    Targeting CD70 with Cusatuzumab Eliminates Acute Myeloid Leukemia Stem Cells in Patients Treated with Hypomethylating Agents

    Scientists demonstrated that leukemia stem cells upregulated the tumor necrosis factor family ligand CD70 in response to hypomethylating agent treatment resulting in increased CD70/CD27 signaling.
    [Nature Medicine]

    Abstract

    Activation of the Receptor Tyrosine Kinase, RET, Improves Long-Term Hematopoietic Stem Cell Outgrowth and Potency

    Researchers demonstrated a role for the glial family ligand receptor, RET, at the cell surface of hematopoietic stem cells, in mediating sustained cellular growth, resistance to stress and improved cell survival throughout in vitro expansion.
    [Blood]

    Abstract

    The BET Inhibitor CPI203 Promotes Ex Vivo Expansion of Cord Blood Long-Term Repopulating HSCs and Megakaryocytes

    Of ten compounds tested, only the bromodomain and extra-terminal motif inhibitor CPI203 enhanced the expansion of human cord blood hematopoietic stem cells without losing cell viability in vitro.
    [Blood]

    Abstract

    Identification of the SRC-Family Tyrosine Kinase HCK as a Therapeutic Target in Mantle Cell Lymphoma

    Investigators showed that the SRC-family tyrosine kinase hematopoietic cell kinase (HCK), which is primarily expressed in the hematopoietic lineage but not in mature B cells, was aberrantly expressed in mantle cell lymphoma (MCL), and that high expression of HCK was associated with inferior prognosis of MCL patients.
    [Leukemia]

    Full Article

    Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells

    The authors showed that a lncRNA, MORRBID, a selective transcriptional repressor of BIM, was overexpressed in human acute myeloid leukemia, which is associated with poor overall survival.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Dectin-1 Stimulation of Hematopoietic Stem and Progenitor Cells Occurs In Vivo and Promotes Differentiation Toward Trained Macrophages via an Indirect Cell-Autonomous Mechanism

    Scientists used an hematopoietic stem and progenitor cell (HSPC) transplantation model to investigate the possible direct interaction of β-glucan and its receptor on HSPCs in vivo.
    [mBio]

    Full Article

    Driver Mutations in Leukemia Promote Disease Pathogenesis through a Combination of Cell-Autonomous and Niche Modulation

    Researchers showed that constitutive and early loss of the epigenetic regulator, TET2, when combined with constitutive activation of FLT3, resulted in transformation of chronic myelomonocytic leukemia-like or myeloproliferative neoplasm-like phenotype to acute myeloid leukemia, which was more pronounced in double-mutant mice relative to mice carrying mutations in single genes.
    [Stem Cell Reports]

    Full Article

    Comparison of Efficacy and Health-Related Quality of Life of First-Line Haploidentical Hematopoietic Stem Cell Transplantation with Unrelated Cord Blood Infusion and First-Line Immunosuppressive Therapy for Acquired Severe Aplastic Anemia

    Scientists retrospectively compared the efficacy and health-related quality of life of first-line haploidentical hematopoietic stem cell transplantation combined with unrelated cord blood infusion and first-line immunosuppressive therapy in acquired severe aplastic anemia patients.
    [Leukemia]

    Abstract

    HSPG2 Overexpression Independently Predicts Poor Survival in Patients with Acute Myeloid Leukemia

    The mRNA expression level of heparan sulfate proteoglycan 2 (HSPG2) in bone marrow mononuclear cells and CD34+ hematopoietic stem/progenitor cells obtained from enrolled participants and human leukemic cell lines was detected by RT-qPCR.
    [Cell Death & Disease]

    Full Article

    Long-Term Outcomes and Risk Factor Analysis of Steroid-Refractory Graft versus Host Disease after Hematopoietic Stem Cell Transplantation

    Researchers conducted a retrospective study on outcomes and risk factors associated with acute and chronic steroid-refractory graft versus host disease in a large cohort of 1207 patients receiving hematopoietic stem cell transplantation in Saint Louis Hospital between 2007 and 2017.
    [Bone Marrow Transplantation]

    Abstract

    The StemSpanâ„¢ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    REVIEWS

    The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing

    The authors review recent advances in the understanding of native hematopoiesis, focusing in particular on the application of genetic lineage tracing in mice.
    [Annual Review of Cell and Developmental Biology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Medigene Enters Phase I Clinical Development with Its TCR-T Immunotherapy MDG1021 in Hematological Cancers

    Medigene AG has received approval from the Dutch regulatory authority to begin a first clinical trial of MDG1021. MDG1021, which targets the antigen HA-1, thus becomes Medigene’s second proprietary T cell receptor-modified T cell immunotherapy candidate to enter clinical development.
    [Medigene AG]

    Press Release

    Gender Gap in Research Output Widens during Pandemic

    A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
    [The Scientist]

    Editorial

    FEATURED EVENT

    The New York Stem Cell Foundation (NYSCF) Conference

    October 20 – October 21
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Stem Cell and iPSC Biology

    University of Illinois at Chicago – Chicago, Illinois, United States

    Postdoctoral Researcher – RNA Epitranscriptomics and Immune Cells

    Lund University – Lund, Sweden

    Postdoctoral Position – Immune Privilege of the Stem Cell Niche

    Columbia University – New York, New York, United States

    Postdoctoral Fellow – Hematopoietic Stem Cell Biology

    University of Illinois at Chicago – Chicago, Illinois, United States

    PhD Student Position – Epigenetic Regulation of Hematopoietic Stem Cells

    Karolinska Institutet – Huddinge, Sweden

    PhD Studentship – Erythropoiesis

    University of Bristol – Bristol, United Kingdom

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Hematopoiesis News Twitter