| Vol. 11.25 – 30 June, 2020 |
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| The authors identified 19,632 autosomal mosaic chromosomal alterations and analyzed these for relationships to inherited genetic variation. They found 52 inherited, rare, large-effect coding or splice variants in seven genes that were associated with greatly increased vulnerability to clonal hematopoiesis with specific acquired copy-neutral loss of heterozygosity mutations. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists describe shared and population-specific patterns of genomic mutations and clonal selection in hematopoietic cells on the basis of 33,250 autosomal mosaic chromosomal alterations that they detected in 179,417 Japanese participants in the BioBank Japan cohort and compared with analogous data from the UK Biobank. [Nature] |
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| Investigators applied a barcoding strategy to clonal tracking of edited cells and showed that editing activated p53, which substantially shrank the hematopoietic stem cell clonal repertoire in hematochimeric mice, although engrafted edited clones preserved multilineage and self-renewing capacity. [Nature Biotechnology] |
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| Scientists demonstrated that leukemia stem cells upregulated the tumor necrosis factor family ligand CD70 in response to hypomethylating agent treatment resulting in increased CD70/CD27 signaling. [Nature Medicine] |
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| Researchers demonstrated a role for the glial family ligand receptor, RET, at the cell surface of hematopoietic stem cells, in mediating sustained cellular growth, resistance to stress and improved cell survival throughout in vitro expansion. [Blood] |
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| Of ten compounds tested, only the bromodomain and extra-terminal motif inhibitor CPI203 enhanced the expansion of human cord blood hematopoietic stem cells without losing cell viability in vitro. [Blood] |
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| Investigators showed that the SRC-family tyrosine kinase hematopoietic cell kinase (HCK), which is primarily expressed in the hematopoietic lineage but not in mature B cells, was aberrantly expressed in mantle cell lymphoma (MCL), and that high expression of HCK was associated with inferior prognosis of MCL patients. [Leukemia] |
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| The authors showed that a lncRNA, MORRBID, a selective transcriptional repressor of BIM, was overexpressed in human acute myeloid leukemia, which is associated with poor overall survival. [Cell Reports] |
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| Scientists used an hematopoietic stem and progenitor cell (HSPC) transplantation model to investigate the possible direct interaction of β-glucan and its receptor on HSPCs in vivo. [mBio] |
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| Researchers showed that constitutive and early loss of the epigenetic regulator, TET2, when combined with constitutive activation of FLT3, resulted in transformation of chronic myelomonocytic leukemia-like or myeloproliferative neoplasm-like phenotype to acute myeloid leukemia, which was more pronounced in double-mutant mice relative to mice carrying mutations in single genes. [Stem Cell Reports] |
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| Scientists retrospectively compared the efficacy and health-related quality of life of first-line haploidentical hematopoietic stem cell transplantation combined with unrelated cord blood infusion and first-line immunosuppressive therapy in acquired severe aplastic anemia patients. [Leukemia] |
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| The mRNA expression level of heparan sulfate proteoglycan 2 (HSPG2) in bone marrow mononuclear cells and CD34+ hematopoietic stem/progenitor cells obtained from enrolled participants and human leukemic cell lines was detected by RT-qPCR. [Cell Death & Disease] |
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| Researchers conducted a retrospective study on outcomes and risk factors associated with acute and chronic steroid-refractory graft versus host disease in a large cohort of 1207 patients receiving hematopoietic stem cell transplantation in Saint Louis Hospital between 2007 and 2017. [Bone Marrow Transplantation] |
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| The authors review recent advances in the understanding of native hematopoiesis, focusing in particular on the application of genetic lineage tracing in mice. [Annual Review of Cell and Developmental Biology] |
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| Medigene AG has received approval from the Dutch regulatory authority to begin a first clinical trial of MDG1021. MDG1021, which targets the antigen HA-1, thus becomes Medigene’s second proprietary T cell receptor-modified T cell immunotherapy candidate to enter clinical development. [Medigene AG] |
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| A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers. [The Scientist] |
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| October 20 – October 21 Virtual |
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| University of Illinois at Chicago – Chicago, Illinois, United States |
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| Lund University – Lund, Sweden |
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| Columbia University – New York, New York, United States |
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| University of Illinois at Chicago – Chicago, Illinois, United States |
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| Karolinska Institutet – Huddinge, Sweden |
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| University of Bristol – Bristol, United Kingdom |
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