| Vol. 11.27 – 14 July, 2020 |
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| Researchers integrated over 8,000 transcriptomes and 2,000 samples with multilevel genomics of hematological cancers to investigate how immunological features are linked to cancer subtypes, genetic and epigenetic alterations, and patient survival, and validated key findings experimentally. [Cancer Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors identified six endogenous retrovirus families with acute myeloid leukemia (AML)-associated enhancer chromatin signatures that were enriched in binding of key regulators of hematopoiesis and AML pathogenesis. [Nature Communications] |
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| Scientists showed that integrins play a key role during fly hematopoiesis in regulating cell signals that control the behavior of hematopoietic progenitors. Integrins could regulate hematopoiesis directly, via focal adhesion kinase signaling, and indirectly, by directing ECM assembly and/or maintenance. [Current Biology] |
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| Investigators describe the transcriptome of Mysm1-deficient mouse hematopoietic stem cells and identified MYSM1 genome-wide DNA binding sites. [JCI Insight] |
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| Scientists showed that alpha lipoic acid promoted production of human pluripotent stem cell derived hemogenic endothelial cells and hematopoietic stem/progenitor cells in vitro. [Journal of Leukocyte Biology] |
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| Inspired by recent proteomic data demonstrating the upregulation of carbon and glycogen metabolism in aging human hematopoietic stem and progenitor cells, scientists addressed whether this was caused by elevated glycolysis of the hematopoietic stem and progenitor cells on a per cell basis, or by a subpopulation that has become more glycolytic. [Scientific Reports] |
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| To imitate the natural microenvironment, a 3D engineered scaffold for CD34+ cells co-culture was established via 3D bioprinting. The concentration of hydrogel and the ratio of two kinds of cells were optimized. [Scientific Reports] |
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| To understand the role of HUWE1 in human hematopoietic stem and progenitor cells scientists constitutively expressed KRASG12V oncogene concomitantly to HUWE1 knockdown in stromal co-cultures. [Cancer Gene Therapy] |
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| The authors performed a nationwide retrospective study of graft-versus-host disease (GvHD)-free, relapse-free survival of patients with allogeneic hematopoietic stem cell transplantation (HSCT)-treated adult T-cell leukemia/lymphoma. [Bone Marrow Transplantation] |
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| Researchers reviewed pre‐diagnosis clinical data of 420 patients with pathologically confirmed myelodysplastic syndromes presenting with anemia. [Hematological Oncology] |
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| The authors review prognostic factors in lower risk MDS, delineating patients with relatively poor risk who may potentially benefit from hematopoietic stem cell transplantation during the disease course. [Leukemia] |
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| Ziopharm Oncology, Inc. announced the initiation of a Phase I clinical trial to evaluate CD19-specific CAR-T, using its Rapid Personalized Manufacturing technology, as an investigational treatment for patients with relapsed CD19+ leukemias and lymphomas. [ZIOPHARM Oncology Inc.] |
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| Merck announced that the FDA has accepted and granted priority review for a new supplemental Biologics License Application for KEYTRUDA, Merck’s anti-PD-1 therapy, as monotherapy for the treatment of adult patients with relapsed or refractory classical Hodgkin lymphoma. [Merck & Co., Inc.] |
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| To address the problem of poor reporting, Percie du Sert and a team of researchers have developed a checklist of 10 critical details each animal study needs to report, such as the number of animals used, their sex, whether they were randomly allocated to a test group and control group, and whether the researchers knew which animal was in which group. [ScienceInsider] |
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| September 30 – October 3 Virtual |
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| Karolinska Institutet – Huddinge, Sweden |
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| University of Illinois at Chicago – Chicago, Illinois, United States |
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| Lund University – Lund, Sweden |
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| Columbia University – New York, New York, United States |
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| University of Illinois at Chicago – Chicago, Illinois, United States |
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