| Vol. 11.28 – 21 July, 2020 |
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| Researchers assessed the hematopoietic stem cell content within the CD34+ fraction of graft samples from three groups of patients: 1-Good Mobilizer patients receiving G-CSF only, 2-Poor Mobilizer (PM) patients receiving G-CSF only, 3-PM patients receiving G-CSF + Plerixafor. [Leukemia] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators found that loss of zinc finger HIT-type containing 1 (Znhit1) led to exhaustion of stem cell pool and impairment of hematopoietic function. [Leukemia] |
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| Scientists established that bone morphogenetic protein (BMP) signaling was required for self-renewal of adult hematopoietic stem cells (HSCs). Through conditional knockout they showed that BMPR-II deficient HSCs have impaired self-renewal and regenerative capacity. [Haematologica] |
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| The authors aimed to understand the effect of cell competition on thymopoiesis, identify the cells involved, and determine how the process is regulated. [Cell Reports] |
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| Scientists found that the expression of STAP-1 was aberrantly upregulated in chronic myeloid leukemia (CML) stem cells in patients’ bone marrow. [Oncogene] |
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| 2F5 was confirmed to induce G0/G1 phase arrest in acute promyelocytic leukemia (APL) cells, and promoted APL cell differentiation combined with decreased DDX5 expression and increased reactive oxygen species production. Knockdown of DDX5 by siRNA also inhibited proliferation, promoted cell differentiation and enhanced ROS production in APL cells. [Cell Death & Disease] |
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| At the molecular level, functional deficiency of the Nlrp3 inflammasome in hematopoietic stem progenitor cells led to their defective migration in response to the major bone marrow homing chemoattractant stromal-derived factor 1 and to other supportive chemoattractants, including sphingosine-1-phosphate and extracellular adenosine triphosphate. [Stem Cell Reviews and Reports] |
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| Researchers tested the effects of specific modulation of Toll like receptor (TLR)1/2 versus TLR2/6 signaling on premalignant hematopoietic stem and progenitor cells. [Experimental Hematology] |
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| Scientists investigated the effects of preeclampsia in pregnancy on the stemness and differentiation potency of umbilical cord blood-hematopoietic stem cells. [BMC Pregnancy and Childbirth] |
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| The authors provide detailed discussion of the nature of 3D interactions and the way that they are disrupted in acute leukemia. [Leukemia] |
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| Orchard Therapeutics announced that the company has received both orphan drug designation and rare pediatric disease designation from the FDA for OTL-203, an ex vivo autologous hematopoietic stem cell gene therapy in development for the treatment of mucopolysaccharidosis type I. [Orchard Therapeutics Limited] |
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| Following a marathon EU summit in Brussels, national leaders agreed to a €1.8 trillion, seven-year budget and pandemic recovery fund that will spend €81 billion on Horizon Europe, the main EU research program. [ScienceInsider] |
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| Come August, hundreds of universities across the United States are poised to reopen their campuses with a mix of online and in-person courses. Only a handful are aiming for an entirely online semester. But as the machinery of higher education cranks back into action, faculty, staff, and students are voicing concerns that, with COVID-19 cases surging in many parts of the country, employees are being forced to put their health—and the health of others—at unnecessary risk. [ScienceInsider] |
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| August 27 – August 29 Virtual |
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| Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| University of Illinois at Chicago – Chicago, Illinois, United States |
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| Lund University – Lund, Sweden |
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| Columbia University – New York, New York, United States |
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| University of Illinois at Chicago – Chicago, Illinois, United States |
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