Hematopoiesis News Volume 11.28 | Jul 21 2020

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    2020-07-21 | HN 11.28


    Hematopoiesis News by STEMCELL Technologies
    Vol. 11.28 – 21 July, 2020
    TOP STORY

    Characteristics of Cells with Engraftment Capacity within CD34+ Cell Population upon G-CSF and Plerixafor Mobilization

    Researchers assessed the hematopoietic stem cell content within the CD34+ fraction of graft samples from three groups of patients: 1-Good Mobilizer patients receiving G-CSF only, 2-Poor Mobilizer (PM) patients receiving G-CSF only, 3-PM patients receiving G-CSF + Plerixafor.
    [Leukemia]

    Abstract

    Use STEMvisionâ„¢ for Automated Hematopoietic CFU Assay Imaging & Analysis.
    PUBLICATIONSRanked by the impact factor of the journal

    Chromatin Remodeler Znhit1 Preserves Hematopoietic Stem Cell Quiescence by Determining the Accessibility of Distal Enhancers

    Investigators found that loss of zinc finger HIT-type containing 1 (Znhit1) led to exhaustion of stem cell pool and impairment of hematopoietic function.
    [Leukemia]

    Full Article

    BMP Signaling Is Required For Postnatal Murine Hematopoietic Stem Cell Self-Renewal

    Scientists established that bone morphogenetic protein (BMP) signaling was required for self-renewal of adult hematopoietic stem cells (HSCs). Through conditional knockout they showed that BMPR-II deficient HSCs have impaired self-renewal and regenerative capacity.
    [Haematologica]

    Abstract

    Cell Competition, the Kinetics of Thymopoiesis, and Thymus Cellularity Are Regulated by Double-Negative 2 to 3 Early Thymocytes

    The authors aimed to understand the effect of cell competition on thymopoiesis, identify the cells involved, and determine how the process is regulated.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Signal-Transducing Adapter Protein-1 Is Required for Maintenance of Leukemic Stem Cells in CML

    Scientists found that the expression of STAP-1 was aberrantly upregulated in chronic myeloid leukemia (CML) stem cells in patients’ bone marrow.
    [Oncogene]

    Abstract

    DDX5-Targeting Fully Human Monoclonal Autoantibody Inhibits Proliferation and Promotes Differentiation of Acute Promyelocytic Leukemia Cells by Increasing ROS Production

    2F5 was confirmed to induce G0/G1 phase arrest in acute promyelocytic leukemia (APL) cells, and promoted APL cell differentiation combined with decreased DDX5 expression and increased reactive oxygen species production. Knockdown of DDX5 by siRNA also inhibited proliferation, promoted cell differentiation and enhanced ROS production in APL cells.
    [Cell Death & Disease]

    Full Article

    Nlrp3 Inflammasome Signaling Regulates the Homing and Engraftment of Hematopoietic Stem Cells (HSPCs) by Enhancing Incorporation of CXCR4 Receptor into Membrane Lipid Rafts

    At the molecular level, functional deficiency of the Nlrp3 inflammasome in hematopoietic stem progenitor cells led to their defective migration in response to the major bone marrow homing chemoattractant stromal-derived factor 1 and to other supportive chemoattractants, including sphingosine-1-phosphate and extracellular adenosine triphosphate.
    [Stem Cell Reviews and Reports]

    Full Article

    TLR2/6 Signaling Promotes the Expansion of Premalignant Hematopoietic Stem and Progenitor Cells in the NUP98HOXD13 Mouse Model of MDS

    Researchers tested the effects of specific modulation of Toll like receptor (TLR)1/2 versus TLR2/6 signaling on premalignant hematopoietic stem and progenitor cells.
    [Experimental Hematology]

    Abstract

    Preeclampsia in Pregnancy Affecting the Stemness and Differentiation Potency of Hematopoietic Stem Cell of the Umbilical Cord Blood

    Scientists investigated the effects of preeclampsia in pregnancy on the stemness and differentiation potency of umbilical cord blood-hematopoietic stem cells.
    [BMC Pregnancy and Childbirth]

    Full Article

    The StemSpanâ„¢ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    REVIEWS

    Determinants and Role of Chromatin Organization in Acute Leukemia

    The authors provide detailed discussion of the nature of 3D interactions and the way that they are disrupted in acute leukemia.
    [Leukemia]

    Abstract

    INDUSTRY AND POLICY NEWS

    Orchard Therapeutics Announces Orphan Drug and Rare Pediatric Disease Designations for OTL-203 for the Treatment of MPS-I

    Orchard Therapeutics announced that the company has received both orphan drug designation and rare pediatric disease designation from the FDA for OTL-203, an ex vivo autologous hematopoietic stem cell gene therapy in development for the treatment of mucopolysaccharidosis type I.
    [Orchard Therapeutics Limited]

    Press Release

    EU Leaders Slash Science Spending in €1.8 Trillion Deal

    Following a marathon EU summit in Brussels, national leaders agreed to a €1.8 trillion, seven-year budget and pandemic recovery fund that will spend €81 billion on Horizon Europe, the main EU research program.
    [ScienceInsider]

    Editorial

    ‘Ethically Troubling.’ University Reopening Plans Put Professors, Students on Edge

    Come August, hundreds of universities across the United States are poised to reopen their campuses with a mix of online and in-person courses. Only a handful are aiming for an entirely online semester. But as the machinery of higher education cranks back into action, faculty, staff, and students are voicing concerns that, with COVID-19 cases surging in many parts of the country, employees are being forced to put their health—and the health of others—at unnecessary risk.
    [ScienceInsider]

    Editorial

    FEATURED EVENT

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    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Hematopoiesis, Marrow Failure and Myeloid Leukemia

    Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States

    Postdoctoral Research Associate – Stem Cell and iPSC Biology

    University of Illinois at Chicago – Chicago, Illinois, United States

    Postdoctoral Researcher – RNA Epitranscriptomics and Immune Cells

    Lund University – Lund, Sweden

    Postdoctoral Position – Immune Privilege of the Stem Cell Niche

    Columbia University – New York, New York, United States

    Postdoctoral Fellow – Hematopoietic Stem Cell Biology

    University of Illinois at Chicago – Chicago, Illinois, United States

    > See All Jobs

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