 | | Vol. 11.30 – 4 August, 2020 |
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| The authors demonstrated that the absence of hematopoietic CXCL4 ameliorated the myeloproliferative neoplasm phenotype, reduced stromal cell activation and bone marrow fibrosis and decreased the activation of pro-fibrotic pathways in megakaryocytes, inflammation in fibrosis-driving cells and JAK/STAT activation in both megakaryocytes and stromal cells in three murine primary myelofibrosis models.
[Blood] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists describe an ex vivo editing approach to achieve efficient gene targeting in human hematopoietic stem/progenitor cells and robust expression of clinically relevant proteins by the erythroid lineage.
[Nature Communications] |
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| Scientists showed that Itgav deletion results in increased frequency of phenotypic hematopoietic stem cells in fetal liver due to faster proliferation.
[Stem Cell Reports] |
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| 16,16-dimethyl prostaglandin E2 suppressed hematopoietic stem cell proliferation through 24 hour post ionizing radiation, which correlated with fewer DNA double-strand breaks and attenuation of apoptosis, mitochondrial compromise, oxidative stress, and senescence.
[Stem Cell Reports] |
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| Researchers retrospectively analyzed 4649 acute myeloid leukemia (AML) patients who received allogeneic hematopoietic cell transplantation and were in complete remission. Outcomes of Philadelphia chromosome-positive AML, intermediate-risk, and poor-risk AML patients were compared.
[Bone Marrow Transplantation] |
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| To characterize mutation accumulation in individual stem and progenitor cells of Down syndrome and karyotypically normal fetuses, the authors clonally expanded single cells and performed whole-genome sequencing. They found a higher mutation rate in hematopoietic stem and progenitor cells during fetal development compared to the post-infant rate.
[Scientific Reports] |
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| Researchers adapted a centrifugation-based method for the isolation of murine bone marrow and compared it to the traditional flushing method. Analysis of primary hematopoietic stem cells, immune cells, and megakaryocytes revealed a comparable distribution of cellular (sub)populations.
[Platelets] |
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| Investigators demonstrated the impact of donor type on overall results of allogeneic stem cell transplantation for very-high risk pediatric acute lymphoblastic leukemia with worse results when using mismatched donor stem cell source.
[Bone Marrow Transplantation] |
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| Researchers review recent studies linking clonal hematopoiesis to altered immune function, inflammation, and non-malignant diseases of aging.
[Blood] |
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| Scientists describe a framework by which an understanding of the processes that promote clonal hematopoiesis in inherited bone marrow failure syndromes may inform clinical surveillance strategies.
[Blood] |
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| Ex vivo hematopoietic stem cell derivation from renewable sources such as induced pluripotent stem cells offers an experimental tool for studying developmental hematopoiesis, disease modeling, and drug discovery, and yields tremendous therapeutic potential for malignant and nonmalignant hematological disorders.
[Stem Cells Translational Medicine] |
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| Biosight Ltd. announced that that the FDA has granted Fast Track designation for BST-236 for the treatment of acute myeloid leukemia in adults who are 75 years or older, or who have comorbidities that preclude use of intensive induction chemotherapy.
[Biosight Ltd. (GlobeNewswire, Inc.)] |
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| Research advocates were eager to learn who Health and Human Services Secretary Alex Azar would appoint to the board and to see its ideological makeup. On July 31st they got their first look as it gathered online for a one-time meeting run by the National Institutes of Health.
[ScienceInsider] |
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| June 21 – June 23, 2021
Lyon, France |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | The Francis Crick Institute – London, United Kingdom |
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| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| | University of Illinois at Chicago – Chicago, Illinois, United States |
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| | Columbia University – New York, New York, United States |
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