 | | Vol. 11.31 – 11 August, 2020 |
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| Researchers profiled the chromatin accessibility and transcriptional features of zebrafish nascent- and fetal HSPCs using ATAC-seq and RNA-seq and revealed dynamic changes during HSPC transition.
[Blood] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators examined the CD34+c-Kit+Flt3+ myeloid progenitor population as potential mutation carrier in all langerhans cell histiocytosis disease manifestations.
[Blood] |
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| Researchers showed that, in stark contrast to results published for other Polycomb repressive complex 2 subunits, genetic depletion of Phf19 increased hematopoietic stem cell identity and quiescence.
[Science Advances] |
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| Investigators showed that myelodysplastic NUP98‑HOXD13 transgenic mice displayed an abnormally high number of osteoblasts, yet a higher fraction of nonmineralized bone, indicating delayed bone mineralization. This was accompanied by high fibroblast growth factor-23 serum levels, a phosphaturic hormone that inhibits bone mineralization and erythropoiesis.
[JCI Insight] |
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| Scientists report that physiologically relevant oxygen concentration, an important environmental thymic factor promoted differentiation of cord blood CD34+ cells into progenitor T cells in serum‐free and feeder‐free culture system. This effect was enhanced by a potent reducing and antioxidant agent, ascorbic acid.
[Stem Cells] |
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| The authors demonstrated that similar to mouse bone marrow and human cord blood, collection and processing of mouse granulocyte colony stimulating factor (G-CSF)-, AMD3100/Plerixafor- or G-CSF plus AMD3100/Plerixafor-mobilized HSCs in 3% O2 resulted in enhanced numbers of rigorously-defined phenotypic and for G-CSF – and G-CSF plus AMD3100/Plerixafor – mPB enhanced functionally-engrafting hematopoietic stem cells.
[Stem Cell Reviews and Reports] |
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| Investigators determined the effect of alcohol exposure on sonic hedgehog signaling in the regulation of hematopoietic stem cell activation during bacteremia.
[Alcoholism-Clinical and Experimental Research] |
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| Researchers describe the role of HoxB4 in indirectly inhibiting the emergence of mature CD45+ hematopoietic stem cells from induced pluripotent stem cells in vitro.
[Experimental Hematology] |
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| The authors analyzed prognostic gene mutations by targeted next-generation sequencing to identify predisposing factors for predicting overall survival at one month before transplantation. They enrolled 120 patients with nonremission acute myeloid leukemia who underwent first allogeneic hematopoietic stem cell transplantation (allo-HSCT) between 2005 and 2018.
[Bone Marrow Transplantation] |
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| Scientists treated 14 relapsed or refractory diffuse large B-cell lymphoma patients by combining autologous hematopoietic stem cell transplantation and anti-CD19 chimeric antigen receptor T-cell therapy.
[Immunotherapy] |
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| The authors discuss the history, biologic effect, and clinical impact of fusion genes in the field of myeloid leukemias.
[Stem Cells] |
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| Investigators highlight the functional consequences of inhibiting and activating mitochondrial proteases and discuss their potential as therapeutic targets in acute myeloid leukemia.
[Stem Cells Translational Medicine] |
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| Results of the trials, which evaluated the safety and efficacy of CD30 CAR-T cell therapy in patients with relapsed/refractory Hodgkin lymphoma, showed a high rate of durable complete responses and very favorable safety profile using autologous CD30 CAR-T cell therapy.
[Tessa Therapeutics Ltd.] |
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| BryoLogyx, Inc. announced that it has entered into a Cooperative Research and Development Agreement with the National Cancer Institute, to conduct a Phase I clinical trial with bryostatin-1 in pediatric and young adult patients with relapsing or refractory CD22 expressing acute lymphoblastic leukemia and lymphoma.
[BryoLogyx, Inc.] |
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| November 2 – November 3
Virtual |
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| | Princeton University – Princeton, New Jersey, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | The Francis Crick Institute – London, United Kingdom |
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| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| | Columbia University – New York, New York, United States |
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