 | | Vol. 11.32 – 18 August, 2020 |
| |
|
|
| Scientists found that differentiation-inactive, multilineage, and lineage-restricted hematopoietic stem cell clones reside in distinct regions of the transcriptional landscape of hematopoiesis.
[Cell Stem Cell] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Inhibition of TGFβ signaling led to reversal of age-associated hematopoietic stem cell (HSC) platelet lineage bias, increased generation of lymphoid progenitors and rebalanced HSC lineage output in transplantation assays.
[Nature Communications] |
|
|
|
| Scientists showed that a CRISPR/Cas9-based genome editing strategy allowed the precise correction of Wiskott-Aldrich syndrome mutations in up to 60% of human hematopoietic stem and progenitor cells, without impairing cell viability and differentiation potential.
[Nature Communications] |
|
|
|
| The authors demonstrated that NLRP3 inflammasome-mediated interleukin-1-beta signaling drives hematopoietic stem and progenitor cell production in response to metabolic activity.
[Developmental Cell] |
|
|
|
| Scientists used nanostraws to target human primary hematopoietic stem and progenitor cells and showed efficient delivery of mRNA, short interfering RNAs, DNA oligonucleotides, and dextrans of sizes ranging from 6 kDa to 2,000 kDa.
[Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Designed novel lentiviral constructs harbored a global promoter regulating mCherry for hematopoietic stem cell selection and a T-cell specific promoter upstream of eGFP.
[Scientific Reports] |
|
|
|
| Researchers compared the effects of tyrosine kinase inhibitors belonging to different generations, imatinib and ponatinib, on progenitor/stem cell expansion potential and markers.
[Targeted Oncology] |
|
|
|
| Investigators assessed the effect of nicotinamide on myeloid differentiation of the IL-3 dependent, multipotent hematopoietic progenitor cell line FDCP-Mix.
[Stem Cell Reviews and Reports] |
|
|
|
| The authors studied function recovery at the scar zone and its impact in global left ventricular function after intracoronary injection of hematopoietic precursor cells.
[ESC Heart Failure] |
|
|
|
| | Researchers measured relative telomere length in pre-transplant recipient blood samples in 1514 myelodysplastic syndrome (MDS) patients and evaluated the association of telomere length with MDS disease characteristics and transplantation outcomes.
[Blood] |
|
|
|
| Scientists developed a comprehensive system for predicting non-relapse mortality after allogeneic hematopoietic cell transplantation during first complete remission of acute myeloid leukemia.
[Bone Marrow Transplantation] |
|
|
|
| Autologous hematopoietic stem cell transplantation was an intensive but well tolerated and effective treatment option for patients with Stiff Person Syndrome refractory to conventional immunotherapy.
[Journal of Neurology] |
|
|
|
|
| The authors provide a summary of the pathology, the transcriptional profile and genetic and immune-phenotypic features of human angioimmunoblastic lymphoma (AITL). In addition, they give an overview of preclinical models that recapitulate more or less faithfully human AITL characteristics and pathology.
[Oncogenesis] |
|
|
|
|
| Mustang Bio, Inc. announced that the FDA has granted Rare Pediatric Disease Designation to MB-107, Mustang’s lentiviral gene therapy for the treatment of X-linked severe combined immunodeficiency, also known as bubble boy disease, in newly-diagnosed infants.
[Mustang Bio, Inc.] |
|
|
|
| TG Therapeutics, Inc. announced that the FDA has accepted the company’s New Drug Application for umbralisib, the company’s investigational once-daily, oral, dual inhibitor of PI3K-delta and CK1-epsilon, as a treatment for patients with previously treated marginal zone lymphoma who have received at least one prior anti-CD20 based regimen and follicular lymphoma who have received at least two prior systemic therapies.
[TG Therapeutics, Inc.] |
|
|
|
|
| July 8 – July 10, 2021
Boston, Massachusetts, United States |
|
|
|
|
|
| | Karolinska Institutet – Huddinge, Sweden |
|
|
|
| | Princeton University – Princeton, New Jersey, United States |
|
|
|
| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
|
|
|
| | The Francis Crick Institute – London, United Kingdom |
|
|
|
| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
