 | | Vol. 11.33 – 25 August, 2020 |
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| Detailed metabolomic analysis revealed elevated nicotinamide metabolism in relapsed leukemia stem cells (LSCs), which activated both amino acid metabolism and fatty acid oxidation to drive OXPHOS, thereby providing a means for LSCs to circumvent the cytotoxic effects of venetoclax and azacitidine therapy.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| A detailed characterization of ribosome biogenesis dynamics during human and murine erythropoiesis showed that ribosome biogenesis was abruptly interrupted by the drop of rDNA transcription and the collapse of ribosomal protein neo-synthesis.
[Blood] |
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| Researchers demonstrated that severe polycomb repressive complex 2 (PRC2) insufficiency induced by the deletion of one allele Ezh1 in Ezh2-deficient mice caused advanced dyserythropoiesis accompanied by a differentiation block and enhanced apoptosis in erythroblasts.
[Leukemia] |
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| Investigators characterized the distribution of FLT3-ITD mutation in different progenitor cell subsets to shed light on the subclonal architecture of FLT3-ITDmut acute myeloid leukemia.
[Blood Cancer Journal] |
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| In an MLL-AF9 AML mouse model, genetic deletion of β-catenin, or even all four Tcf/Lef family transcription factors that interact with β-catenin, did not affect AML onset in primary recipients, or the ability of leukemic stem cells in propagating AML in secondary recipients.
[eLife] |
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| Investigators generated a foxn1/Casper mutant zebrafish that was transparent and exhibited T cell deficiency. By employing the line for hematopoietic stem cell transplantation, they achieved nonconditioned transplantation.
[Stem Cell Reports] |
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| Researchers analyzed blood samples of 70 aplastic anemia (AA) and 18 dyskeratosis congenita (DKC) patients to demonstrate that their epigenetic age predictions were overall increased, albeit not directly correlated with telomere length. Aberrant DNA methylation was observed in the gene PRDM8 in DKC and AA as well as in other diseases with premature aging phenotype, such as Down syndrome and Hutchinson-Gilford-Progeria syndrome.
[Clinical Epigenetics] |
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| Investigators capitalized on the 35 kb insert capacity of HDAd5/35++ vectors to demonstrate that transcriptional regulatory regions of the β-globin locus with a total length of 29 kb could efficiently be transferred into hematopoietic stem/progenitor cells (HSPCs). The in vivo HSPC transduction resulted in stable γ-globin levels in erythroid cells that conferred a complete cure of murine thalassemia intermedia.
[JCI Insight] |
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| A novel strategy was developed to support ex vivo expansion of hematopoietic stem and progenitor cells by coculture with engineered human umbilical arterial endothelial cells, which expressed E4ORF1 stably by using a retroviral system.
[Stem Cell Research & Therapy] |
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| Using nationwide registration data, scientists compared the transplant outcomes of patients who developed graft failure and underwent salvage cord blood transplanatation using immunosuppressants, including calcineurin (CNI) alone; CNI plus methotrexate; and CNI plus mycophenolate mofetil.
[Bone Marrow Transplantation] |
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| Within CD34+ hematopoietic stem and progenitor cells the authors identified CD34+CD38+ progenitor cells as a highly apoptosis-resistant population, while CD34+CD38− hematopoietic stem/multipotent progenitor cells as a population very sensitive to radiation-induced apoptosis.
[Scientific Reports] |
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| | Researchers retrospectively analyzed the outcomes of 214 severe aplastic anemia patients who underwent allogeneic hematopoietic stem cell transplantation with r-ATG or ATG-Fresenius.
[Biology of Blood and Marrow Transplantation] |
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| The authors evaluated the outcomes of patients with hypoplastic myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation.
[International Journal of Hematology] |
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| Scientists review basic biological principles of epigenetic polarity, with a special focus on epi-polarity and aging of hematopoietic stem cells.
[Human Molecular Genetics] |
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| Bristol Myers Squibb announced that the Phase III IDHENTIFY study evaluating IDHIFA® plus best supportive care (BSC) versus conventional care regimens, which include BSC only, azacitidine plus BSC, low-dose cytarabine plus BSC or intermediate-dose cytarabine plus BSC, did not meet the primary endpoint of overall survival in patients with relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation.
[Bristol Myers Squibb] |
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| Primary HLH is a family of devastating primary immune deficiencies with limited treatment options and no gene therapies under clinical testing. Expression Therapeutics has developed a promising and potentially curative gene therapy candidate for familial HLH type 3.
[Expression Therapeutics (PR Newswire Association LLC.)] |
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| May 18 – May 21, 2021
Hannover, Germany |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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| | Karolinska Institutet – Huddinge, Sweden |
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| | Princeton University – Princeton, New Jersey, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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