Hematopoiesis News Volume 11.35 | Sep 8 2020

May 12, 2022

2020-09-08 | HN 11.35

Hematopoiesis News by STEMCELL Technologies

Vol. 11.35 – 8 September, 2020

TOP STORY

Synthetic Immunomodulation with a CRISPR Super-Repressor In Vivo

Investigators demonstrated transcriptional repression of the myeloid differentiation primary response 88 gene in vitro and in vivo.
[Nature Cell Biology]

Abstract

Request your free copy of the 'Bone Marrow Niches and HSC Fates' Wallchart

PUBLICATIONSRanked by the impact factor of the journal

CHD7
and Runx1 Interaction Provides a Braking Mechanism for Hematopoietic Differentiation

Genetic disruption of the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7) expanded phenotypic hematopoietic stem and progenitor cells, erythroid, and myeloid lineages in zebrafish and mouse embryos.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

Controlled
Cycling and Quiescence Enables Efficient HDR in Engraftment-Enriched Adult Hematopoietic Stem and Progenitor Cells

Researchers used a combination of immunophenotyping, next-generation sequencing, and single-cell RNA sequencing to investigate and reprogram genome editing outcomes in subpopulations of adult hematopoietic stem and progenitor cells.
[Cell Reports]

Full Article Graphical Abstract

Chronic
Loss of STAG2 Leads to Altered Chromatin Structure Contributing to De-Regulated Transcription in AML

Scientists used functional genomics to investigate the impact of chronic STAG2 loss on three-dimensional genome structure and transcriptional programming in a clinically relevant model of chronic STAG2 loss.
[Journal of Translational Medicine]

Full Article

Substitution
of Thr572 to Ala in Mouse C-Myb Attenuates Progression of Early Erythroid Differentiation

In this study, scientists showed the T572-dependent downregulation of c-Myb protein was required for proper differentiation in early-stage erythroblasts.
[Scientific Reports]

Full Article

Interleukin
7 Receptor (IL7R) Is Required for Myeloid Cell Homeostasis and Reconstitution by Hematopoietic Stem Cells

Researchers report that traditional, hematopoietic stem cell-derived myeloid cells in the adult lung, peripheral blood, and bone marrow also depended on interleukin 7 receptor expression.
[Experimental Hematology]

Abstract Graphical Abstract

CLINICAL RESEARCH

Effects
of Acute and Chronic Graft-versus-Myelodysplastic Syndrome on Long-Term Outcomes following Allogeneic Hematopoietic Cell Transplantation

Scientists retrospectively evaluated the impact of acute and chronic graft-versus-host disease on transplant outcomes for a large cohort of adult patients with a low-risk and high-risk myelodysplastic syndrome treated by first allogeneic hematopoietic cell transplantation between 2001 and 2017.
[Clinical Cancer Research]

Abstract

Better
Leukemia-Free Survival with Allogeneic Than with Autologous HCT in AML Patients with Isolated Trisomy 8: A Study from the ALWP of the EBMT

Investigators compared outcomes of such patients given either allo-hematopoietic stem cell transplantation (HCT) or autologous (auto)-HCT. Inclusion criteria consisted of adult patients with de novo AML, isolated trisomy 8, first HCT between 2000 and 2018, CR1 at transplantation, and either auto-HCT or allo-HCT with a HLA-identical sibling donor or a 10/10 HLA-matched unrelated donor.
[Bone Marrow Transplantation]

Abstract

The
Role of EVI1 Gene Quantification in AML Patients with 11q23/MLL Rearrangement after Allogeneic Hematopoietic Stem Cell Transplantation

Scientists analyzed the clinical value of EVI1 gene quantification in 96 AML patients with 11q23/MLL rearrangement.
[Bone Marrow Transplantation]

Abstract

Request your free copy of the 'Frequencies of Cell Types in Human Peripheral Blood' Wallchart

REVIEWS

Autologous
Hematopoietic Stem Cell Transplantation in Neurological Disorders: Current Approach and Future Directions

Scientists discuss the use of autologous hematopoietic stem cell transplantation in these neurological disorders, the importance of patient selection and transplant technique optimization and future directions.
[Expert Review of Neurotherapeutics]

Abstract

TIFA
and TIFAB: FHA-Domain Proteins Involved in Inflammation, Hematopoiesis, and Disease

The authors summarize the molecular mechanisms and biological role of forkhead-associated domain-domain homologues, placing them into the context of human disease.
[Experimental Hematology]

Full Article

INDUSTRY AND POLICY NEWS

Celularity
Doses First Patient in Clinical Trial Evaluating CYNK-001 in COVID-19 Patients

Celularity announced that the first patient was dosed in a Phase I/II study of human placental hematopoietic stem cell derived NK cells for the treatment of adults with COVID-19 as part of a national clinical trial.
[Celularity Inc.]

Press Release

US
Food and Drug Administration Approves Onureg^® (Azacitidine Tablets), a New Oral Therapy, as Continued Treatment for Adults in First Remission with Acute Myeloid Leukemia

Bristol Myers Squibb announced that the FDA has approved Onureg^® for the continued treatment of adult patients with acute myeloid leukemia who achieved first complete remission (CR) or CR with incomplete blood count recovery following intensive induction chemotherapy and who are not able to complete intensive curative therapy.
[Bristol Myers Squibb, Inc.]

Press Release

FEATURED EVENT

Synthetic Immunomodulation with a CRISPR Super-Repressor In Vivo

CHD7
and Runx1 Interaction Provides a Braking Mechanism for Hematopoietic Differentiation

Controlled
Cycling and Quiescence Enables Efficient HDR in Engraftment-Enriched Adult Hematopoietic Stem and Progenitor Cells

Chronic
Loss of STAG2 Leads to Altered Chromatin Structure Contributing to De-Regulated Transcription in AML

Substitution
of Thr572 to Ala in Mouse C-Myb Attenuates Progression of Early Erythroid Differentiation

Interleukin
7 Receptor (IL7R) Is Required for Myeloid Cell Homeostasis and Reconstitution by Hematopoietic Stem Cells

Effects
of Acute and Chronic Graft-versus-Myelodysplastic Syndrome on Long-Term Outcomes following Allogeneic Hematopoietic Cell Transplantation

Better
Leukemia-Free Survival with Allogeneic Than with Autologous HCT in AML Patients with Isolated Trisomy 8: A Study from the ALWP of the EBMT

The
Role of EVI1 Gene Quantification in AML Patients with 11q23/MLL Rearrangement after Allogeneic Hematopoietic Stem Cell Transplantation

Autologous
Hematopoietic Stem Cell Transplantation in Neurological Disorders: Current Approach and Future Directions

TIFA
and TIFAB: FHA-Domain Proteins Involved in Inflammation, Hematopoiesis, and Disease

Celularity
Doses First Patient in Clinical Trial Evaluating CYNK-001 in COVID-19 Patients

US
Food and Drug Administration Approves Onureg^® (Azacitidine Tablets), a New Oral Therapy, as Continued Treatment for Adults in First Remission with Acute Myeloid Leukemia

Cancer Research & Oncology 2020

> See All Events

Research Associate – Blood Stem Cell Biology

Assistant
Professor – Immunology Research

Postdoctoral Studies – Stem Cells and Erythropoiesis in MDS

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes

Postdoctoral Research Fellow – Hematopoiesis, Marrow Failure and Myeloid Leukemia

Postdoctoral Fellow – Immunology, Genetics, Precision Medicine

> See All Jobs