Hematopoiesis News Volume 11.37 | Sep 22 2020

    0
    24







    2020-22-09 | HN 11.37


    Hematopoiesis News by STEMCELL Technologies
    Vol. 11.37 – 22 September, 2020
    TOP STORY

    Multi-Layered
    Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development

    To identify secreted signals underlying human hematopoietic stem cell development, scientists combined spatial transcriptomics analysis of dorsoventral polarized signaling in the aorta with gene expression profiling of sorted cell populations and single cells.
    [Cell Stem Cell]

    AbstractGraphical Abstract


    Stay up-to-date with the latest stem cell research by listening to the Stem Cell Podcast!
    PUBLICATIONSRanked by the impact factor of the journal

    Protein
    Quality Control through Endoplasmic Reticulum-Associated Degradation Maintains Hematopoietic Stem Cell Identity and Niche Interactions

    The authors report endoplasmic reticulum-associated degradation as a protein quality checkpoint that controlled the hematopoietic stem cell (HSC)–niche interaction and determined the fate of HSCs.
    [Nature Cell Biology]

    Abstract

    The
    Lysophospholipase D Enzyme Gdpd3 Is Required to Maintain Chronic Myelogenous Leukemia Stem Cells

    Investigators showed that disruption of the Gdpd3 gene encoding a lysophospholipase D enzyme significantly decreased self-renewal capacity in murine chronic myelogenous leukemia stem cells in vivo.
    [Nature Communications]

    Full ArticleEditorial

    Vast
    Self-Renewal Potential of Human AGM Region HSCs Dramatically Declines in the Umbilical Cord Blood

    Researchers showed that a single human aorta-gonad-mesonephros region hematopoietic stem cell (HSC) could generate 600–1,600 functional daughter HSCs.
    [Stem Cell Reports]

    Full Article

    Preclinical
    Evaluation of a Regimen Combining Chidamide and ABT-199 in Acute Myeloid Leukemia

    Scientists reported that a newly emerged histone deacetylase inhibitor, chidamide, at low-cytotoxicity dose enhanced the anti-AML activity of ABT-199, while sparing normal hematopoietic progenitor cells.
    [Cell Death & Disease]

    Full Article

    Modeling
    Transient Abnormal Myelopoiesis Using Induced Pluripotent Stem Cells and CRISPR/Cas9 Technology

    Investigators employed disease modeling in vitro by the use of customizable induced pluripotent stem cells to generate a transient abnormal myelopoiesis model.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractGraphical Abstract

    Dnmt3a-Null
    Hematopoietic Progenitor Stem Cells Expand after Busulfan Treatment

    Scientists used a competitive transplantation mouse model to investigate how treatment with common preconditioning agents 5-fluorouracil or busulfan affects the prevalence of Dnmt3a-/- hematopoietic stem cells and progenitor cells in competition with WT cells.
    [Experimental Hematology]

    AbstractGraphical Abstract

    CLINICAL RESEARCH

    Reduced-Intensity
    Conditioning Is Effective for Hematopoietic Stem Cell Transplantation in Young Pediatric Patients with Diamond-Blackfan Anemia

    Researchers retrospectively compared the outcomes of Diamond-Blackfan anemia patients who underwent hematopoietic stem cell transplantation using either myeloablative conditioning or reduced-intensity conditioning regimens.
    [Bone Marrow Transplantation]

    Abstract


    Request your free copy of the 'Frequencies of Cell Types in Human Peripheral Blood' Wallchart
    REVIEWS

    Unraveling Hematopoiesis through the Lens of Genomics

    The authors describe how recently uncovered complexities are reshaping the concept of tissue development and homeostasis while opening up a more comprehensive future understanding of hematopoiesis.
    [Cell]

    Full Article

    Roles
    of Fibrinolytic Factors in the Alterations in Bone Marrow Hematopoietic Stem/Progenitor Cells during Bone Repair

    Osteoblasts, osteoclasts, chondrocytes, and macrophages involved in the bone repair process originate from hematopoietic stem/progenitor cells and mesenchymal stem cells in the bone marrow.
    [Inflammation and Regeneration]

    Full Article

    INDUSTRY AND POLICY NEWS

    Jasper Therapeutics Doses First Patient in Phase I Clinical Trial of JSP191 as Conditioning Agent for Patients with Myelodysplastic Syndromes/Acute Myeloid Leukemia Undergoing Hematopoietic Cell Transplantation

    Jasper Therapeutics, Inc. announced that the first patient has been dosed in a multicenter Phase I clinical trial of JSP191, a first-in-class humanized monoclonal antibody.
    [Jasper Therapeutics, Inc. (Business Wire, Inc.)]

    Press Release

    Mustang Bio Announces Orphan Drug Designation for MB-207 for the Treatment of X-Linked Severe Combined Immunodeficiency (“XSCID”) in Previously Transplanted Patients

    Mustang Bio, Inc. announced that the FDA has granted Orphan Drug Designation to MB-207, Mustang’s lentiviral gene therapy for the treatment of patients with XSCID, also known as bubble boy disease, who have been previously treated with a hematopoietic stem cell transplantation and for whom re-treatment is indicated.
    [Mustang Bio, Inc.]

    Press Release

    CRISPR
    Therapeutics and Vertex Pharmaceuticals Announce Priority Medicines (PRIME) Designation Granted by the European Medicines Agency (EMA) to CTX001™ for the Treatment of Sickle Cell Disease

    CRISPR Therapeutics and Vertex Pharmaceuticals Inc. announced the European Medicines Agency has granted Priority Medicines designation to CTX001™, an investigational, autologous, ex vivo CRISPR/Cas9 gene-edited therapy for the treatment of severe sickle cell disease.
    [CRISPR Therapeutics AG]

    Press Release

    FEATURED EVENT

    Till & McCulloch Meetings 2020

    October 26 – October 28
    Virtual


    > See All Events

    JOB OPPORTUNITIES


    Postdoctoral Fellow – Hematopoietic Stem Cell Biology

    University of Illinois at Chicago – Chicago, Illinois, United States

    Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Research
    Technician – Human Candidate Disease Genes Identified in Various Genome-Wide Association

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Research
    Associate – Blood Stem Cell Biology

    University of York – Heslington Campus – York, United Kingdom

    Assistant
    Professor – Immunology Research

    Princeton University – Princeton, New Jersey, United States

    Postdoctoral Fellow – Immunology, Genetics, Precision Medicine

    St. Anna Children’s Cancer Research Institute – Vienna, Austria

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Science News Hematopoiesis News
    Archives Contact Us
    Hematopoiesis News Twitter