| Vol. 11.37 – 22 September, 2020 |
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| To identify secreted signals underlying human hematopoietic stem cell development, scientists combined spatial transcriptomics analysis of dorsoventral polarized signaling in the aorta with gene expression profiling of sorted cell populations and single cells. [Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors report endoplasmic reticulum-associated degradation as a protein quality checkpoint that controlled the hematopoietic stem cell (HSC)–niche interaction and determined the fate of HSCs. [Nature Cell Biology] |
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| Investigators showed that disruption of the Gdpd3 gene encoding a lysophospholipase D enzyme significantly decreased self-renewal capacity in murine chronic myelogenous leukemia stem cells in vivo. [Nature Communications] |
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| Researchers showed that a single human aorta-gonad-mesonephros region hematopoietic stem cell (HSC) could generate 600–1,600 functional daughter HSCs. [Stem Cell Reports] |
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| Scientists reported that a newly emerged histone deacetylase inhibitor, chidamide, at low-cytotoxicity dose enhanced the anti-AML activity of ABT-199, while sparing normal hematopoietic progenitor cells. [Cell Death & Disease] |
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| Investigators employed disease modeling in vitro by the use of customizable induced pluripotent stem cells to generate a transient abnormal myelopoiesis model. [Molecular Therapy-Methods & Clinical Development] |
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| Scientists used a competitive transplantation mouse model to investigate how treatment with common preconditioning agents 5-fluorouracil or busulfan affects the prevalence of Dnmt3a-/- hematopoietic stem cells and progenitor cells in competition with WT cells. [Experimental Hematology] |
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| Researchers retrospectively compared the outcomes of Diamond-Blackfan anemia patients who underwent hematopoietic stem cell transplantation using either myeloablative conditioning or reduced-intensity conditioning regimens. [Bone Marrow Transplantation] |
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| The authors describe how recently uncovered complexities are reshaping the concept of tissue development and homeostasis while opening up a more comprehensive future understanding of hematopoiesis. [Cell] |
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| Osteoblasts, osteoclasts, chondrocytes, and macrophages involved in the bone repair process originate from hematopoietic stem/progenitor cells and mesenchymal stem cells in the bone marrow. [Inflammation and Regeneration] |
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| Jasper Therapeutics, Inc. announced that the first patient has been dosed in a multicenter Phase I clinical trial of JSP191, a first-in-class humanized monoclonal antibody. [Jasper Therapeutics, Inc. (Business Wire, Inc.)] |
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| Mustang Bio, Inc. announced that the FDA has granted Orphan Drug Designation to MB-207, Mustang’s lentiviral gene therapy for the treatment of patients with XSCID, also known as bubble boy disease, who have been previously treated with a hematopoietic stem cell transplantation and for whom re-treatment is indicated. [Mustang Bio, Inc.] |
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| CRISPR Therapeutics and Vertex Pharmaceuticals Inc. announced the European Medicines Agency has granted Priority Medicines designation to CTX001™, an investigational, autologous, ex vivo CRISPR/Cas9 gene-edited therapy for the treatment of severe sickle cell disease. [CRISPR Therapeutics AG] |
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| October 26 – October 28 Virtual |
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| University of Illinois at Chicago – Chicago, Illinois, United States |
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| University of York – Heslington Campus – York, United Kingdom |
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| Princeton University – Princeton, New Jersey, United States |
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| St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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