 | | Vol. 11.38 – 29 September, 2020 |
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| Investigators studied the contribution of nestin+ bone marrow mesenchymal stem cells to MLL-AF9-driven acute myeloid leukemia development and chemoresistance in vivo.
[Cell Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers report that macroautophagy, a catabolic membrane trafficking pathway that degrades cellular components through autophagosomes and lysosomes, mediated the downregulation of mammalian SIRT1 protein during senescence and in vivo aging.
[Nature Cell Biology] |
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| The authors investigated the mechanism by which ibrutinib induces thrombocytopenia using cord blood CD34+ hematopoietic stem cells, a human megakaryoblastic cell line, and C57BL/6 mice.
[Thrombosis and Haemostasis] |
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| Investigators showed that fibroblast growth factor receptor 3 (FGFR3) inactivation accelerated bone marrow suppression-induced hematopoietic stem and progenitor cell expansion by upregulating FGFR1 and its downstream transcriptional factor, ELK, which regulates the expression of Cyclin D1 gene at the level of transcription.
[Biology of Blood and Marrow Transplantation] |
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| Researchers found that ZBTB38, a different member of the broad complex, tram track, bric-a-brac and zinc finger family that binds methylated DNA at CpG motifs, was highly expressed by germinal center B cells and plasma cells.
[PLoS One] |
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| | The authors designed a combination of haplo‐hematopoietic stem cells transplantation with allogenic mesenchymal stem cells for treatment of severe aplastic anemia in pediatric and adolescent patients and evaluated its effects.
[Stem Cells Translational Medicine] |
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| Researchers retrospectively compared the outcome of pediatric patients undergoing T-replete haploidentical HSCT for acute leukemia with those undergoing transplantation from unrelated HLA-matched donor and HLA mismatched unrelated donor from 2012 to 2017 at our Center.
[Bone Marrow Transplantation] |
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| Outpatient second hematoprogenitors transplant after reduced‐intensity conditioning at a single academic center was analyzed. Twenty‐seven consecutive adults who received an allogeneic hematopoietic stem cell transplantation (allo‐HSCT) after an initial auto‐ or allo‐HSCT from 2006 to 2019 were included.
[Hematological Oncology] |
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| This retrospective analysis aimed to investigate the outcomes associated with hematopoietic stem cell transplantation (HSCT), and the risks of HSCT in children and adolescents with nonremission acute lymphoblastic leukemia.
[Pediatric Blood & Cancer] |
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| Scientists review studies on the role of autophagy in acute myeloid leukemia (AML) development and summarize the linkage between autophagy and several recurrent genetic abnormalities in AML, highlighting the potential of capitalizing on autophagy modulation in targeted therapy for AML.
[Autophagy] |
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| Vor Biopharma and Arbor Biotechnologies announced an agreement to use Arbor’s gene editing technologies to engineer hematopoietic stem cells, towards the goal of developing therapies for the treatment of blood cancers, such as acute myeloid leukemia.
[Vor Biopharma] |
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| Orchard Therapeutics announced that the European Medicines Agency has granted Priority Medicines designation to OTL-203, an investigational ex vivo autologous hematopoietic stem cell gene therapy in development for the treatment of mucopolysaccharidosis type I at the San Raffaele Telethon Institute for Gene Therapy.
[Orchard Therapeutics plc.] |
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| April 12 – April 15, 2021
Breckenridge, Colorado, United States |
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| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| | University of Illinois at Chicago – Chicago, Illinois, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | University of York – Heslington Campus – York, United Kingdom |
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| | Princeton University – Princeton, New Jersey, United States |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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