Hematopoiesis News Volume 11.39 | Oct 6 2020

May 12, 2022

2020-06-10 | HN 11.39

Hematopoiesis News by STEMCELL Technologies

Vol. 11.39 – 6 October, 2020

TOP STORY

MYC
Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia

To identify determinants of bone marrow failure, researchers performed single-cell transcriptome profiling of primary hematopoietic stem and progenitor cells from Fanconi anemia patients.
[Cell Stem Cell]

Abstract Graphical Abstract

Dr. Daniel Dever, describes a CRISPR-Cas9-based protocol for gene editing hematopoietic stem cells in this on-demand webinar.

PUBLICATIONSRanked by the impact factor of the journal

Nanoparticle-Encapsulated
siRNAs for Gene Silencing in the Hematopoietic Stem-Cell Niche

Scientists report the design and in vivo performance of systemically injected lipid–polymer nanoparticles encapsulating small interfering RNA, for the silencing of genes in bone-marrow endothelial cells.
[Nature Biomedical Engineering]

Abstract

Platelet-Derived
Microparticles Enhance Megakaryocyte Differentiation and Platelet Generation via miR-1915-3p

The authors showed that, during mouse acute liver injury, the density of megakaryocyte in the bone marrow increases following an increase in circulating platelet-derived microparticles, but without thrombopoietin upregulation.
[Nature Communications]

Full Article

Activation of CpG-Rich Promoters Mediated by MLL Drives MOZ
-Rearranged Leukemia

Scientists describe the circuitry of a transactivation system responsible for oncogenic self-renewal. MLL recruited RNA polymerase II to unmethylated CpG-rich promoters by its CXXC domain and activated transcription by transcriptional regulators, including the AF4 family/ENL family/P-TEFb complex, DOT1L, and p300/CBP histone acetyl transferases.
[Cell Reports]

Full Article Graphical Abstract

tagHi-C
Reveals 3D Chromatin Architecture Dynamics during Mouse Hematopoiesis

Investigators introduced a low-input tagmentation-based Hi-C (tagHi-C) method to capture the chromatin structures of hundreds of cells. Using tagHi-C, they were able to map the spatiotemporal dynamics of chromatin structure in ten primary hematopoietic stem, progenitor, and differentiated cell populations from mouse bone marrow.
[Cell Reports]

Full Article Graphical Abstract

Increased
Baseline RASGRP1 Signals Enhance Stem Cell Fitness during Native Hematopoiesis

The authors expanded RASGRP1 expression surveys in pediatric T-ALL and generated a RoLoRiG mouse model crossed to Mx1CRE to determine the consequences of induced RASGRP1 overexpression in primary hematopoietic cells.
[Oncogene]

Abstract

Haploinsufficiency
of Cohesin Protease, Separase, Promotes Regeneration of Hematopoietic Stem Cells in Mice

Scientists report that partial disruption of Separase distinctly alters the functional characteristics of hematopoietic stem/progenitor cells.
[Stem Cells]

Abstract

HbF
Levels in Sickle Cell Disease Are Associated with Proportion of Circulating Hematopoietic Stem and Progenitor Cells and CC-Chemokines

Researchers report that the proportions of Lin-CD34⁺38^– hematopoietic multipotent cells and of Lin-CD34⁺38⁺ hematopoietic progenitors cells were highly variable between individuals but stable over long periods of time, in both healthy individuals and sickle cell disease patients.
[Cells]

Full Article

High-Fat Diet Intensifies MLL-AF9-Induced
Acute Myeloid Leukemia through Activation of the FLT3 Signaling in Mouse Primitive Hematopoietic Cells

Using a MLL-AF9 knock-in mouse model, researchers discovered that consumption of a high-fat diet accelerates the risk of developing acute myeloid leukemia.
[Scientific Reports]

Full Article

The
Functional Interplay of Transcription Factors and Cell Adhesion Molecules in Experimental Myelodysplasia including Hematopoietic Stem Progenitor Compartment

Investigators made an attempt to find out the osteoblastic niche related alterations in the myelodysplastic bone marrow through mainly flow cytometric and fluorescent microscopic studies.
[Molecular and Cellular Biology]

Abstract

CLINICAL RESEARCH

Competitive
sgRNA Screen Identifies p38 MAPK as a Druggable Target to Improve HSPC Engraftment

Scientists performed a targeted CRISPR-Cas9-based sgRNA screen to identify candidate genes that counteract the decreased repopulating capacity of hematopoietic stem and progenitor cells during gene therapy.
[Cells]

Full Article

Learn more about cGMP-manufactured StemSpan™-ACF Without Phenol Red for culturing hematopoietic cell therapy products

REVIEWS

Splenic
Hematopoietic and Stromal Cells in Cancer Progression

Tumor-derived secretory factors orchestrate splenic hematopoietic and stromal cells to fuel metastasis. The spleen acts as a reservoir site for hematopoietic stem and progenitor cells, which are rapidly exploited as myeloid-derived suppressor cells at the cost of tumor-reactive lymphoid cells.
[Cancer Research]

Abstract

INDUSTRY AND POLICY NEWS

Gamida
Cell Announces Positive Topline Data on Secondary Endpoints from Phase III Clinical Study of Omidubicel in Patients with Hematologic Malignancies

Gamida Cell Ltd. announced that the Phase III study of omidubicel, an investigational advanced cell therapy in development as a potential life-saving treatment option for patients in need of bone marrow transplant, met all three of its secondary endpoints.
[Gamida Cell Ltd.]

Press Release

bluebird
bio Announces European Medicines Agency’s Acceptance of Marketing Authorization Application (MAA) for Elivaldogene Autotemcel (eli-cel, Lenti-D™) Gene Therapy for Cerebral Adrenoleukodystrophy (CALD)

bluebird bio, Inc. announced that the European Medicines Agency accepted the company’s MAA for its investigational elivaldogene autotemcel gene therapy for the treatment of patients with CALD.
[bluebird bio, Inc.]

Press Release

FEATURED EVENT

MYC
Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia

Nanoparticle-Encapsulated
siRNAs for Gene Silencing in the Hematopoietic Stem-Cell Niche

Platelet-Derived
Microparticles Enhance Megakaryocyte Differentiation and Platelet Generation via miR-1915-3p

Activation of CpG-Rich Promoters Mediated by MLL Drives MOZ
-Rearranged Leukemia

tagHi-C
Reveals 3D Chromatin Architecture Dynamics during Mouse Hematopoiesis

Increased
Baseline RASGRP1 Signals Enhance Stem Cell Fitness during Native Hematopoiesis

Haploinsufficiency
of Cohesin Protease, Separase, Promotes Regeneration of Hematopoietic Stem Cells in Mice

HbF
Levels in Sickle Cell Disease Are Associated with Proportion of Circulating Hematopoietic Stem and Progenitor Cells and CC-Chemokines

High-Fat Diet Intensifies MLL-AF9-Induced
Acute Myeloid Leukemia through Activation of the FLT3 Signaling in Mouse Primitive Hematopoietic Cells

The
Functional Interplay of Transcription Factors and Cell Adhesion Molecules in Experimental Myelodysplasia including Hematopoietic Stem Progenitor Compartment

Competitive
sgRNA Screen Identifies p38 MAPK as a Druggable Target to Improve HSPC Engraftment

Splenic
Hematopoietic and Stromal Cells in Cancer Progression

Gamida
Cell Announces Positive Topline Data on Secondary Endpoints from Phase III Clinical Study of Omidubicel in Patients with Hematologic Malignancies

bluebird
bio Announces European Medicines Agency’s Acceptance of Marketing Authorization Application (MAA) for Elivaldogene Autotemcel (eli-cel, Lenti-D™) Gene Therapy for Cerebral Adrenoleukodystrophy (CALD)

The
Evolving Tumor Microenvironment In Cancer Progression: Mechanisms And Emerging Therapeutic Opportunities

> See All Events

Senior Research Assistant – Experimental Hematology & Cancer Biology

Postdoctoral Fellow – Hematopoietic Stem Cell Biology

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes

Assistant
Professor – Immunology Research

Postdoctoral Fellow – Immunology, Genetics, Precision Medicine

> See All Jobs