 | | Vol. 11.40 – 13 October, 2020 |
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| Investigators report that loss of the F-Box protein FBXO11, a component of the SCF ubiquitin ligase complex, conferred cytokine independent growth to MDS-L cells, suggesting a tumor suppressor role for FBXO11 in myeloid malignancies.
[Blood Cancer Journal] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers established that although extracellular vesicle (EV) particle size, concentration, and total protein content remain relatively consistent over an adult lifespan in humans, EV content evolves during aging and potentially influences hematopoietic stem cell regulation.
[Aging Cell] |
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| The authors expanded RASGRP1 expression surveys in pediatric T-ALL and generated a RoLoRiG mouse model crossed to Mx1CRE to determine the consequences of induced RASGRP1 overexpression in primary hematopoietic cells.
[Oncogene] |
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| Scientists found that SUV39H1 was down-regulated in a variety of leukemias, including MLL-r AML, as compared with normal individuals.
[Oncogene] |
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| The authors describe the role of allogeneic hematopoietic stem cell transplantation in cutaneous T-cell lymphomas, summarize the published data and future perspectives in this area.
[Cancers] |
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| Researchers generated an immortalized erythroid cell line from peripheral blood stem cells of a HbE/β-thalassemia patient. Morphological analysis showed the cells are proerythroblasts with some early basophilic erythroblasts, with no change in morphology over time in culture.
[Scientific Reports] |
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| Investigators found that mitochondrial dysfunction affected terminal differentiation of newly identified erythroid/B-lymphoid progenitors among CD45– Ter119– CD31– triple-negative cells in bone marrow.
[iScience] |
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| The authors retrospectively analyzed 4392 patients with leukemia or myelodysplastic syndrome who received transplants from human leukocyte antigen (HLA)-identical sibling donors to investigate the effects of HLAs on acute graft-versus-host disease.
[Bone Marrow Transplantation] |
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| Scientists report a new patient with a novel frameshift mutation and compared this patient with the previously reported SMARCD2-mutant patients, aiming to provide a more comprehensive understanding of the natural course of the disease.
[Journal of Clinical Immunology] |
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| The authors describe the role of allogeneic hematopoietic stem cell transplantation in cutaneous T-cell lymphomas, and summarize the published data and future perspectives in this area.
[Cancers] |
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| Affimed N.V. announced that the first patient was successfully dosed with allogeneic cord blood-derived natural killer cells preloaded with AFM13 and has moved on to the AFM13 monotherapy phase of the treatment cycle.
[Affimed N.V.] |
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| Gamida Cell Ltd. announced that the Phase III study of omidubicel, an investigational advanced cell therapy in development as a potential life-saving treatment option for patients in need of bone marrow transplant, met all three of its secondary endpoints.
[Gamida Cell Ltd.] |
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| April 9 – April 14, 2021
Washington, DC, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| | University of Illinois at Chicago – Chicago, Illinois, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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