 | | Vol. 11.41 – 20 October, 2020 |
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| Scientists used gene mapping to identify modulators of HSC biology linked to myeloproliferative neoplasms risk, and showed through targeted variant-to-function assays that CHEK2 and GFI1B have roles in altering the function of HSCs to confer disease risk.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| In silico-informed in vitro evaluation of the TET2 germline locus enabled the identification of a causal variant that disrupted a TET2 distal enhancer, resulting in increased self-renewal of hematopoietic stem cells.
[Nature] |
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| The authors report that primitive hematopoietic cells from Shwachman–Diamond syndrome patients present with a reduced activity of the small RhoGTPase Cdc42 and concomitantly a reduced frequency of HSCs polar for polarity proteins.
[Leukemia] |
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| Wild-type EVI1 with S436 available for phosphorylation, but not non-phosphorylatable EVI1-S436A, conferred hematopoietic progenitor cell self-renewal and was associated with significantly higher organized transcriptional patterns.
[Cell Death & Disease] |
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| Scientists compared transplantation of human CD34+ HSPCs purified from three different sources: umbilical cord blood, adult bone marrow, and adult G-CSF mobilized peripheral blood.
[Frontiers in Immunology] |
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| With 16 primary blood samples from 13 patients, researchers demonstrated that photodynamic therapy efficiently killed tumor cells without influencing normal lymphocytes in aggressive diseases such as acute adult T cell leukemia/lymphoma.
[Scientific Reports] |
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| Researchers describe an optimized laboratory-scale workflow whereby lentiviral vector (LV)-containing supernatant was purified and concentrated by sequential chromatographic steps, obtaining biologically active LVs with infectious titer and specific activity in the order of 109 Transducing Unit (TU)/ml and 5×104 TU/ng of HIV Gag p24, respectively.
[Molecular Therapy-Methods & Clinical Development] |
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| The authors investigated the pro-hematopoietic effects and underlying mechanisms of ziyuglycoside II in cyclophosphamide-induced leukopenia in mice.
[Biomedicine & Pharmacotherapy] |
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| Inadequate hematopoietic stem cell infusion dose did not negatively impact autologous hematopoietic stem cell transplantation patient survival but significantly prolonged the time to hematopoietic engraftment.
[Leukemia & Lymphoma] |
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| Researchers review evidence of signals emerging from hematopoietic stem and progenitor cells through secreted autocrine or paracrine factors, including extracellular vesicles, and via direct contact within the niche.
[Leukemia] |
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| Scientists discuss molecular maintenance in leukemia stem cells in chronic myeloid leukemia and provide a more in-depth discussion of the dual-specificity kinase DYRK2, which has been identified as a novel actionable checkpoint in a critical leukemic network.
[Experimental and Molecular Medicine] |
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| The authors highlight recent molecular, biochemical, and genetic studies of KLF1 mutants, particularly the dramatic consequences that come from just a single amino acid change.
[Mutation Research-Reviews in Mutation Research] |
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| Merck announced that the FDA has approved an expanded label for KEYTRUDA, Merck’s anti-PD-1 therapy, as monotherapy for the treatment of adult patients with relapsed or refractory classical Hodgkin lymphoma.
[Merck & Co., Inc.] |
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| Pluristem Therapeutics, Inc. announced that it has received clearance from the safety committee of an investigator initiated Phase I/II study to move forward with patient enrollment for cohort II. The study will evaluate PLX-PAD cells in the treatment of steroid-refractory chronic graft vs. host disease and is led by Principal Investigator Prof. Ron Ram, Director of the Hematology Blood and Marrow Stem Cell Transplantation Unit at Tel Aviv Sourasky Medical Center, Ichilov Hospital, Israel.
[Pluristem Therapeutics, Inc.] |
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| January 25 – January 28, 2021
Virtual |
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| | Karolinska Institutet – Flemingsberg, Sweden |
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| | University of Navarra – Pamplona, Spain |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | University of Illinois at Chicago – Chicago, Illinois, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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