Hematopoiesis News Volume 11.43 | Nov 3 2020

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    Justin.choi
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    2020-03-11 | HN 11.43


    Hematopoiesis News by STEMCELL Technologies
    Vol. 11.43 – 3 November, 2020
    TOP STORY

    Innate Immune Training of Granulopoiesis Promotes Anti-Tumor Activity

    The anti-tumor effect of β-glucan-induced trained immunity was associated with transcriptomic and epigenetic rewiring of granulopoiesis and neutrophil reprogramming toward an anti-tumor phenotype; this process required type I interferon signaling irrespective of adaptive immunity in the host.
    [Cell]

    Full ArticleGraphical Abstract

    SepMate™ PBMC Isolation
    PUBLICATIONSRanked by the impact factor of the journal

    M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity

    Scientists demonstrated that, unlike Bacille Calmette-Guérin or β-glucan, Mycobacterium tuberculosis (Mtb) reprograms HSCs via an IFN-I response that suppresses myelopoiesis and impairs development of protective trained immunity to Mtb.
    [Cell]

    Full ArticleGraphical Abstract

    Zeb1 Modulates Hematopoietic Stem Cell Fates Required for Suppressing Acute Myeloid Leukemia

    Researchers used the hematopoietic system, as a well-established paradigm of stem cell biology, to evaluate Zeb1 mediated regulation of adult stem cells. They employed a conditional genetic approach using the Mx1-Cre system to specifically knockout Zeb1 in adult hematopoietic stem cells and their downstream progeny.
    [Journal of Clinical Investigation]

    Full ArticleGraphical Abstract

    DPP4+ Exosomes in AML Patients’ Plasma Suppress Proliferation of Hematopoietic Progenitor Cells

    Exosomes isolated from acute myeloid leukemia patients’ plasma at diagnosis significantly and dose-dependently suppressed colony formation of normal hematopoietic progenitor cells.
    [Leukemia]

    Abstract

    The IL1-IL1RAP Axis Plays an Important Role in the Inflammatory Leukemic Niche that Favors Acute Myeloid Leukemia Proliferation over Normal Hematopoiesis

    Researchers studied the signaling events downstream of IL1RAP in relation to leukemogenesis and normal hematopoiesis. High IL1RAP expression was associated with a leukemic GMP-like state, and knockdown of IL1RAP in acute myeloid leukemia reduced colony-forming capacity.
    [Haematologica]

    Abstract

    IL-15 Superagonist N-803 Improves IFNγ Production and Killing of Leukemia and Ovarian Cancer Cells by CD34+ Progenitor-Derived NK Cells

    Scientists investigated whether and how N-803 improves hematopoietic progenitor cell-natural killer cell functionality in leukemia and ovarian cancer (OC) models in vitro and in vivo in OC-bearing immunodeficient mice.
    [Cancer Immunology, Immunotherapy]

    Full Article

    Stress Erythropoiesis in Atherogenic Mice

    Researchers showed an increase in the number of circulating erythrocytes in apolipoprotein E−/− mice fed a Western high-fat diet, with similar number of circulating leukocytes and CD41+ events.
    [Scientific Reports]

    Full Article

    Short-Term Ex-Vivo Exposure to Hydrogen Sulfide Enhances Murine Hematopoietic Stem and Progenitor Cell Migration, Homing and Proliferation

    Hydrogen sulfide increases the expression of CXCR4 on HSPCs, enhancing their migration towards SDF-1α in vitro and thus homing to bone marrow niche along with the higher capacity to repopulate.

    [Cell Adhesion & Migration]

    Full Article

    SMIM1 Missense Mutations Exert Their Effect on Wild Type Vel Expression Late in Erythroid Differentiation

    Scientists report how SMIM1 expression is regulated during erythropoiesis, to understand its variable expression on erythrocytes.
    [Transfusion]

    Abstract

    Preemptive Low-Dose Interleukin-2 or DLI for Late-Onset Minimal Residual Disease in Acute Leukemia or Myelodysplastic Syndrome after Allogeneic Hematopoietic Stem Cell Transplantation

    Investigators retrospectively compared the efficacy and safety of preemptive recombinant interleukin-2 and pre-DLI for late-onset minimal residual disease in patients receiving allogeneic hematopoietic stem cell transplantation for acute leukemia or myelodysplastic syndrome.
    [Annals of Hematology]

    Abstract

    The StemSpan™ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    REVIEWS

    A Systematic Review of Machine Learning Techniques in Hematopoietic Stem Cell Transplantation (HSCT)

    A systematic review of the application of machine learning (ML) techniques in the hematopoietic cell transplantation setting was conducted. They examined the type of data streams included, specific ML techniques used, and type of clinical outcomes measured.
    [Sensors]

    Full Article

    INDUSTRY AND POLICY NEWS

    Orphan Drug Designation Granted for CSL Behring’s Investigational Plasma-Derived Hemopexin Therapy for Sickle Cell Disease

    CSL Behring announced that its investigational, plasma-derived hemopexin therapy received orphan drug designation from both the European Commission and the FDA Office of Orphan Products Development for the treatment of sickle cell disease.
    [CSL Behring]

    Press Release

    FEATURED EVENT

    Keystone Symposia: Single Cell Biology

    March 17 – March 19, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Senior Researcher – Translational Medicine and Therapeutics for Leukemia

    Karolinska Institutet – Flemingsberg, Sweden

    Computational Biologist – Transcription and Chromatin Factors in Hematopoiesis

    University of Navarra – Pamplona, Spain

    Clinical Research Associate – Hematology, Oncology, and Bone Marrow Transplantation

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Fellow – Hematopoietic Stem Cell Biology

    University of Illinois at Chicago – Chicago, Illinois, United States

    Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    > See All Jobs

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