 | | Vol. 11.44 – 10 November, 2020 |
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| Rig-I or Mda5 deficiency reduced hematopoietic stem and progenitor cell numbers by inhibiting inflammatory signals that were in turn enhanced in Lgp2 deficient embryos.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Transcriptomic profiles of peripheral blood mononuclear cells were analyzed in heart failure patients harboring DNA methyltransferase 3a (DNMT3A) clonal hematopoiesis-driver mutations and patients with HF and no DNMT3A mutations by single-cell RNA-sequencing.
[Circulation Research] |
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| Investigators showed that the E3 ubiquitin ligase FBXO11 relieved polycomb repressive complex 2 (PRC2)-mediated repression during erythroid maturation by targeting its newly identified substrate BAHD1, an H3K27me3 reader that recruits transcriptional co-repressors.
[Blood] |
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| Utilizing a novel mouse model bearing haploinsufficiency of Tet2, to mimic the human pre-leukemic stem and progenitor cells condition and hyperglycemic stress (HG), in the form of an Ins2Akita/+ mutation, which induced HG and type-1 diabetes mellitus, researchers showed that the compound mutant mice developed a lethal form of myeloproliferative neoplasm and/or acute myeloid leukemia.
[Journal of Clinical Investigation] |
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| Scientists demonstrated that in vitro transduction of normal human CD4+ T lymphocytes with NPM-ALK resulted in their immortalization and malignant transformation.
[Journal of Clinical Investigation] |
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| Using in vitro and in vivo experimental approaches, researchers demonstrated that leptin receptor (Lepr) differentiates SLAM hematopoietic stem cells (HSCs) into two distinct populations; Lepr+ HSCs engrafted better than Lepr− HSCs in primary transplant.
[Leukemia] |
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| Transcriptomic analysis of double knockout bone marrow progenitors revealed that aberrant erythroid skewing was induced by epigenetic changes affecting specific transcriptional factors and cell-cycle regulators.
[Leukemia] |
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| Scientists showed that acute myeloid leukemia (AML) patient blasts consistently expressed the poliovirus receptor-related immunoglobulin domain-containing (PVRIG) ligand. Furthermore, PVRIG blockade significantly enhanced NK cell killing of PVRL2+, poliovirus receptorlo AML cell lines, and significantly increased NK cell activation and degranulation in the context of patient primary AML blasts.
[Haematologica] |
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| Investigators addressed the consequences of spleen tyrosine kinase (SYK) inhibition to leukemia stem-cell function and assessed SYK-associated pathways in acute myeloid leukemia cell biology.
[Cell Death & Disease] |
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| The authors investigated the role of PHF6 in human blood cell development by performing knockdown studies in cord blood and thymus-derived hematopoietic precursors to evaluate the impact on lineage differentiation in well-established in vitro models.
[Frontiers in Cell and Developmental Biology] |
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| Scientists identified the efficacy of ruxolitinib in human leukocyte antigen haploidentical hematopoietic stem cell transplantation recipients with multidrug-resistant-graft-versus-host disease.
[Annals of Hematology] |
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| The authors provide an extensive up-to date summary on the literature of aged hematopoiesis and hematopoietic stem cells (HSCs) placed in context of potential artifacts of the collection and processing procedure, that may not be totally representative of the status of HSCs in their in vivo bone marrow microenvironment, and what the implications of this are for understanding aged hematopoiesis.
[Stem Cell Reviews and Reports] |
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| Forma Therapeutics Holdings, Inc. announced the European Commission granted Orphan Drug designation to Forma’s FT-4202 for the treatment of sickle cell disease, based on a positive opinion from the Committee for Orphan Medicinal Products of the European Medicines Agency.
[Forma Therapeutics Holdings, Inc.] |
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| April 9 – April 14, 2021
Washington, DC, United States |
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| | New York Blood Center – New York, New York, United States |
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| | Karolinska Institutet – Flemingsberg, Sweden |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | University of Illinois at Chicago – Chicago, Illinois, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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