 | | Vol. 11.46 – 24 November, 2020 |
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| Researchers demonstrated that supt16h, a component of the Facilitates chromatin transcription complex, was required for hematopoietic stem and progenitor cell formation.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using a murine model of malaria and combining single-cell RNA sequencing, mathematical modeling, transplantation assays and intravital microscopy, scientists showed that hematopoiesis was reprogrammed upon infection, whereby the HSC compartment turned over substantially faster than at steady-state and HSC function was drastically affected.
[Nature Cell Biology] |
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| Fast-cycling stem-like leukemia cells demonstrated Notch activation and were effectively eliminated in patients by Notch inhibition, while slow cycling stem-like cells were Notch-independent but rather relied on PI3K signaling, likely explaining the poor efficacy of Notch inhibition in this disease.
[Blood] |
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| Scientists demonstrated that mice with RANKL deficiency in MALPs have a drastic increase in trabecular bone mass in long bones and vertebrae starting from one month of age, while their cortical bone appears normal.
[Journal of Clinical Investigation] |
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| Investigators identified nonlinear changes in age-related microRNAs by analyzing whole blood from 1334 healthy individuals. They observed a larger influence of the age as compared to the sex and provide evidence for a shift to the 5’ mature form of miRNAs in healthy aging.
[Nature Communications] |
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| Researchers tested the efficacy and pharmacodynamic activity of an oligonucleotide inhibitor of miR-155, cobomarsen, in non-Germinal Center B-cell or activated B-cell subtype of Diffuse Large B-cell Lymphoma cell lines and in corresponding xenograft mouse models.
[Clinical Cancer Research] |
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| An unbiased RNA-seq approach was developed to interrogate DAC-induced transcriptome changes in AML cell lines with or without a deletion of chromosomes 7q, 5q or 17p. Hypomethylating agent treatment preferentially upregulated several hemizygous tumor suppressor genes in this genomic region, significantly derepressing endogenous retrovirus 3-1 with promoter demethylation, enhanced chromatin accessibility, and increased H3K4me3 levels.
[Cancer Research] |
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| The authors report that dihydropyrimidinase like 2 (DPYSL2), also known as CRMP2, was a novel key differentiation mediator downstream of Krüppel-like factor 4 (KLF4) in acute myeloid leukemia cells.
[Scientific Reports] |
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| Researchers studied Dengue virus infection of MEG-01 cells to understand its effect on megakaryopoiesis and the generation of platelet-like-particles.
[Scientific Reports] |
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| Investigators prospectively measured insulin-like growth factor-l (IGF-l) concentrations in 121 pediatric patients before, during, and after allogeneic hematopoietic stem cell transplantation. Overall, IGF-l levels were significantly reduced compared with healthy sex- and age-matched children.
[Bone Marrow Transplantation] |
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| Scientists tested the use of low-dose memory donor lymphocyte infusion after engraftment of αβ T cell-depleted grafts. A cohort of 131 pediatric patients were grafted with αβ T cell-depleted products from either haplo or unrelated donors.
[Bone Marrow Transplantation] |
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| The authors evaluate evidence for a layered hematopoietic system across species. They discuss mechanisms and selective pressures leading to the temporal generation of different cell types.
[Frontiers in Cell and Developmental Biology] |
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| Orchard Therapeutics announced that the FDA has cleared the company’s Investigational New Drug application for OTL-200, an autologous, hematopoietic stem cell, lentiviral vector-based gene therapy in development for the treatment of MLD.
[Orchard Therapeutics] |
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| BeiGene, Ltd. announced that the China National Medical Products Administration has approved XGEVA® for the prevention of skeletal-related events in patients with bone metastases from solid tumors and in patients with multiple myeloma.
[BeiGene, Ltd.] |
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| September 7 – September 11, 2022
Woods Hole, Massachusetts, United States |
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| | Rubius Therapeutics – Cambridge, Massachusetts, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Stanford University – Stanford, California, United States |
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| | New York Blood Center – New York, New York, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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