Hematopoiesis News Volume 12.02 | Jan 19 2021

    0
    42







    2021-19-01 | HN 12.02


    Hematopoiesis News by STEMCELL Technologies
    Vol. 12.02 – 19 January, 2021
    TOP STORY

    Chaperone-Mediated Autophagy Sustains Hematopoietic Stem-Cell Function

    Scientists showed that chaperone-mediated autophagy, a selective form of lysosomal protein degradation, was involved in sustaining HSC function in adult mice.
    [Nature]

    AbstractPress Release


    Dr. Jackie Damen discusses why the CFU assay should be a vital part of your cell therapy workflow in this on-demand webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Co-Transcriptional
    Splicing Regulates 3′ End Cleavage during Mammalian Erythropoiesis

    To determine how co-transcriptional splicing is integrated with transcription elongation and 3′ end formation in mammalian cells, investigators performed long-read sequencing of individual nascent RNAs and precision run-on sequencing during mouse erythropoiesis.
    [Molecular Cell]

    AbstractGraphical Abstract

    Adrenomedullin-CALCRL
    Axis Controls Relapse-Initiating Drug Tolerant Acute Myeloid Leukemia Cells

    Calcitonin receptor-like receptor (CALCRL) knockdown impaired leukemic growth, decreased leukemic stem cell frequency, and sensitized to cytarabine in patient-derived xenograft models.
    [Nature Communications]

    Full Article

    Oncogenic
    N-Ras Mitigates Oxidative Stress-Induced Apoptosis of Hematopoietic Stem Cells

    The authors expressed oncogenic NrasG12D within the hematopoietic system in mice and interrogated its effects on HSC survival.
    [Cancer Research]

    Abstract

    Aging
    of Human Hematopoietic Stem Cells Is Linked to Changes in Cdc42 Activity

    Investigators report increased frequencies of HSC, HPC and lineage negative cells in the elderly but a decreased frequency of multi-lymphoid progenitors. Aged human HSCs further exhibited a delay in initiating division ex vivo though without changes in their division kinetics.
    [Haematologica]

    Abstract

    Successful
    Gene Therapy of Diamond-Blackfan Anemia in a Mouse Model and Human CD34+ Cord Blood Hematopoietic Stem Cells Using a Clinically Applicable Lentiviral Vector

    Scientists demonstrated the efficacy and safety of using a clinically applicable lentiviral vector for the successful treatment of Rps19-deficient Diamond-Blackfan anemia in a mouse model and in human primary CD34+ cord blood cells.
    [Haematologica]

    Abstract

    Adipose
    Tissue Inflammation and Systemic Insulin Resistance in Mice with Diet-Induced Obesity Is Possibly Associated with Disruption of PFKFB3 in Hematopoietic Cells

    Researchers examined a role for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in hematopoietic cells in regulating white adipose tissue inflammation and systemic insulin sensitivity.
    [Laboratory Investigation]

    Abstract

    Essential
    Role of Autophagy in Protecting Neonatal Hematopoietic Stem Cells from Oxidative Stress in a p62-Independent Manner

    To investigate the effects of Atg5 deletion on stage-specific HSC functions, scientists compared the repopulating capacity of HSCs in Atg5f/f;Vavi-cre mice from postnatal day 0–7 weeks of age.
    [Scientific Reports]

    Full Article

    CD14+
    Monocytes Repress Gamma Globin Expression at Early Stages of Erythropoiesis

    Researchers showed cultured erythroblasts were a mix of HbA restrictive and HbA/HbF expressing cells and that the proportion of cells in the latter population depended on the starting material.
    [Scientific Reports]

    Full Article

    CLINICAL RESEARCH

    Hematopoietic
    Cell Transplant in Pediatric Acute Myeloid Leukemia after Similar Upfront Therapy; A Comparison of Conditioning Regimens

    Investigators retrospectively analyzed the impact of Busulfan–Cyclophosphamide, Busulfan–Cyclophosphamide–Melphalan and Clofarabine–Fludarabine–Busulfan in pediatric AML-patients, with similar upfront leukemia treatment, receiving an hematopoietic cell transplant between 2010 and 2015.
    [Bone Marrow Transplantation]

    Abstract


    Learn about the applications of the CFU assay in toxicity testing from hematopoietic expert Dr. Jackie Damen.
    REVIEWS

    Consensus
    Opinion on Immune-Mediated Cytopenias after Hematopoietic Cell Transplant for Inherited Metabolic Disorders

    The authors summarize the literature, provide an approach to better understanding of the possible etiology of immune mediated cytopenias, and propose a diagnostic and management plan for patients with inherited metabolic disorders who develop single or multi-lineage cytopenias after HSC transplantation.
    [Bone Marrow Transplantation]

    Full Article

    INDUSTRY AND POLICY NEWS

    Vor
    Announces FDA Clearance of IND Application for VOR33

    Vor Biopharma announced that the FDA has cleared the company’s Investigational New Drug (IND) application for VOR33, an engineered HSC therapy candidate being developed for the treatment of acute myeloid leukemia.
    [Vor Biopharma]

    Press Release

    EdiGene
    Announces Approval of Its IND Application for Its CRISPR/Cas 9 Gene-Editing Hematopoietic Stem Cell Therapy ET-01 in β-Thalassemia by China National Medical Products Administration

    EdiGene, Inc. announced the Center for Drug Evaluation of China National Medical Products Administration has approved the company’s Investigational New Drug (IND) application for ET-01, an investigational CRISPR/Cas 9 gene-editing therapy for patients with transfusion dependent β-thalassemia.
    [EdiGene, Inc.]

    Press Release

    Biologics
    License Application for Narsoplimab in HSCT-TMA Accepted for Priority Review by US FDA

    Omeros Corporation announced that the Biologics License Application for narsoplimab for the treatment of HSC transplant-associated thrombotic microangiopathy has been accepted for filing by the FDA.
    [Omeros Corporation]

    Press Release

    FEATURED EVENT

    Hematopoietic
    Stem Cells: Biology, Disease, And Therapy

    March 9, 2021
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Scientific
    Communities & Communications Specialist

    STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada

    Research Associate – Pediatric Myeloid Tumors

    St. Jude Children’s Hospital – Memphis, Tennessee, United States

    Postdoctoral Fellow – Tumor Biology and Therapeutic Applications

    Harvard Medical School – Boston, Massachusetts, United States

    Postdoctoral
    Associate – Epigenetic Mechanisms Governing Hematopoietic Stem Cell Lineage Commitment

    The Jackson Laboratory – Bar Harbor, Maine, United States

    Senior
    Investigator – Replication Stress and Chromatin Alterations

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Scientist – Autoimmunity in AML

    Rubius Therapeutics – Cambridge, Massachusetts, United States

    Research Professional – Life Sciences

    Stanford University – Stanford, California, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Science News Hematopoiesis News
    Archives Contact Us
    Hematopoiesis News Twitter