| Vol. 12.02 – 19 January, 2021 |
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| Scientists showed that chaperone-mediated autophagy, a selective form of lysosomal protein degradation, was involved in sustaining HSC function in adult mice. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| To determine how co-transcriptional splicing is integrated with transcription elongation and 3′ end formation in mammalian cells, investigators performed long-read sequencing of individual nascent RNAs and precision run-on sequencing during mouse erythropoiesis. [Molecular Cell] |
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| Calcitonin receptor-like receptor (CALCRL) knockdown impaired leukemic growth, decreased leukemic stem cell frequency, and sensitized to cytarabine in patient-derived xenograft models. [Nature Communications] |
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| The authors expressed oncogenic NrasG12D within the hematopoietic system in mice and interrogated its effects on HSC survival. [Cancer Research] |
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| Investigators report increased frequencies of HSC, HPC and lineage negative cells in the elderly but a decreased frequency of multi-lymphoid progenitors. Aged human HSCs further exhibited a delay in initiating division ex vivo though without changes in their division kinetics. [Haematologica] |
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| Scientists demonstrated the efficacy and safety of using a clinically applicable lentiviral vector for the successful treatment of Rps19-deficient Diamond-Blackfan anemia in a mouse model and in human primary CD34+ cord blood cells. [Haematologica] |
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| Researchers examined a role for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in hematopoietic cells in regulating white adipose tissue inflammation and systemic insulin sensitivity. [Laboratory Investigation] |
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| To investigate the effects of Atg5 deletion on stage-specific HSC functions, scientists compared the repopulating capacity of HSCs in Atg5f/f;Vavi-cre mice from postnatal day 0–7 weeks of age. [Scientific Reports] |
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| Researchers showed cultured erythroblasts were a mix of HbA restrictive and HbA/HbF expressing cells and that the proportion of cells in the latter population depended on the starting material. [Scientific Reports] |
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| Investigators retrospectively analyzed the impact of Busulfan–Cyclophosphamide, Busulfan–Cyclophosphamide–Melphalan and Clofarabine–Fludarabine–Busulfan in pediatric AML-patients, with similar upfront leukemia treatment, receiving an hematopoietic cell transplant between 2010 and 2015. [Bone Marrow Transplantation] |
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| The authors summarize the literature, provide an approach to better understanding of the possible etiology of immune mediated cytopenias, and propose a diagnostic and management plan for patients with inherited metabolic disorders who develop single or multi-lineage cytopenias after HSC transplantation. [Bone Marrow Transplantation] |
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| Vor Biopharma announced that the FDA has cleared the company’s Investigational New Drug (IND) application for VOR33, an engineered HSC therapy candidate being developed for the treatment of acute myeloid leukemia. [Vor Biopharma] |
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| EdiGene, Inc. announced the Center for Drug Evaluation of China National Medical Products Administration has approved the company’s Investigational New Drug (IND) application for ET-01, an investigational CRISPR/Cas 9 gene-editing therapy for patients with transfusion dependent β-thalassemia. [EdiGene, Inc.] |
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| Omeros Corporation announced that the Biologics License Application for narsoplimab for the treatment of HSC transplant-associated thrombotic microangiopathy has been accepted for filing by the FDA. [Omeros Corporation] |
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| STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
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| St. Jude Children’s Hospital – Memphis, Tennessee, United States |
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| Harvard Medical School – Boston, Massachusetts, United States |
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| The Jackson Laboratory – Bar Harbor, Maine, United States |
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| NIH National Cancer Institute – Bethesda, Maryland, United States |
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| Rubius Therapeutics – Cambridge, Massachusetts, United States |
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| Stanford University – Stanford, California, United States |
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