 | | Vol. 12.05 – 9 February, 2021 |
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| Researchers performed a transcriptomic analysis of the microenvironment of 4,655 diffuse large B-cell lymphomas from multiple independent cohorts and described four major lymphoma microenvironment categories that associate with distinct biological aberrations and clinical behavior.
[Cancer Discovery] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified rare LNGFR+ cells in human fetal and regenerative bone marrow that co-expressed endothelial and stromal markers. This endothelial subpopulation displayed transcriptional reprogramming consistent with endothelial-to-mesenchymal transition and could generate multipotent stromal cells that reconstituted the bone marrow niche upon transplantation.
[Cell Stem Cell] |
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| Investigators used a humanized globin-cluster sickle cell disease mouse model to study Cas9-AAV6-mediated beta-globin-correction in functional hematopoietic stem cells within the context of autologous transplantation.
[Nature Communications] |
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| The authors showed that Mediator interacted directly with E2A-PBX1 through an interaction of the MED1 subunit with an E2A activation domain. Results of MED1 depletion by CRISPR/Cas9 further indicated that MED1 was specifically required for E2A-PBX1–dependent gene activation and leukemic cell growth.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers exploited gene targeted and transgenic mice, and demonstrated that signal-transducing adaptor protein-2 was not required under normal, steady-state conditions.
[Haematologica] |
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| Scientists revealed for the first time that cellular O‐GlcNAcylation levels declined along the course of megakaryocyte differentiation from human‐derived hematopoietic stem and progenitor cells.
[Stem Cells] |
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| Investigators demonstrated that nicotinamide phosphoribosyltransferase (NAMPT) was indispensable for the maintenance, survival, and hematopoietic differentiation of induced pluripotent stem cells.
[Stem Cell Research & Therapy] |
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| Scientists investigated the anti-leukemic effect of the new Calothrixin B derivative, L20, and studied the underlying mechanisms. Cytotoxicity analysis of L20 revealed that it showed significant IC50 concentrations in HEL cells at low doses than in K562, and KG-1a.
[Biomedicine & Pharmacotherapy] |
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| Chronic stimulation with Toll-like receptor (TLR)4 or TLR2 ligands resulted in an expansion of phenotypic HSCs with reduced self-renewal capacity and enhanced myeloid differentiation.
[Experimental Hematology] |
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| The authors explore the role of the multicellular hematopoietic stem cell niche in hematopoiesis and inflammation, and the potential contribution of this niche to the hematopoietic response to obesity.
[JCI Insight] |
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| Bristol Myers Squibb announced that the European Commission has granted full Marketing Authorization for Inrebic® for the treatment of disease-related splenomegaly or symptoms in adult patients with primary myelofibrosis, post-polycythaemia vera myelofibrosis or post-essential thrombocythaemia myelofibrosis, who are Janus Associated Kinase inhibitor naïve or have been treated with ruxolitinib.
[Bristol Myers Squibb] |
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| May 17 – 21, 2021
Virtual |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | Blood Research Institute – Milwaukee, Wisconsin, United States |
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| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | St. Jude Children’s Hospital – Memphis, Tennessee, United States |
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Cancer Stem Cell News
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