 | | Vol. 12.06 – 23 February, 2021 |
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| Single-cell gene expression profiling with parallel mutation detection demonstrated that the megakaryocyte-primed hematopoietic stem cells subpopulation expanded significantly with enhanced potential in untreated individuals with JAK2V617F+essential thrombocythemia, driven primarily by the JAK2 mutation and elevated interferon signaling.
[Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that lysosomal equilibrative nucleoside transporter 3 (ENT3) transport of taurine-conjugated bile acids (TBA) facilitated TBA chemical chaperone function and alleviated endoplasmic reticulum stress in expanding mouse hematopoietic stem and progenitor cells.
[Nature Communications] |
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| Investigators showed that Z-DNA-binding protein 1 (ZBP1) was selectively expressed in late B cell development in both human and mouse cells and it was required for optimal T-cell-dependent humoral immune responses.
[Haematologica] |
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| Using unbiased global sequencing and directed genetic approaches focused on early mammalian development, the authors found that fetal liver macrophage exhibited a unique expression signature that differentiated them from erythroid and adult macrophage cells.
[eLife] |
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| Researchers demonstratef that the splenic microenvironment, specifically 15-PGDH high-expressing macrophages, megakaryocytes, and mast cells, regulated steady-state hematopoiesis and potentiated recovery after bone-marrow transplantation.
[JCI Insight] |
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| Scientists demonstrated that the overexpression of c-Myb and FoxM1 was responsible for the synergistic activation of the WNT5A promoter.
[Scientific Reports] |
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| The safety and preliminary efficacy of venetoclax with low-dose navitoclax and chemotherapy was assessed in this Phase I dose escalation study in pediatric and adult patients with relapsed/refractory acute lymphoblastic leukemia or lymphoblastic lymphoma.
[Cancer Discovery] |
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| By combining gene expression data from cell lines and patients with acute lymphoblastic leukemia, scientists observed that the model was useful for the classification of patients.
[npj Precision Oncology] |
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| Researchers revealed that the expression of miRNAs was aberrant and often heterogeneous in T cell prolymphocytic leukemia (T-PLL). They identified 35 miRNAs that were aberrantly expressed in T-PLL with miR-200c/141 as the most differentially expressed cluster.
[Haematologica] |
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| International collaborative clinical trials have led to better understanding of the underlying molecular biology, refined risk-based stratification, and investigated the use of hematopoietic stem cell transplantation.
[Current Oncology Reports] |
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| The authors discuss their approach to relapsed or refractory diffuse large B cell lymphoma patients and the open question of optimal sequencing of autologous transplant , CAR-T therapy, and bispecific antibodies.
[Current Hematologic Malignancy Reports] |
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| Dr. Salvatore Papa, an Assistant Professor in Cancer Research at the University of Leeds, has been awarded Leukaemia & Myeloma Research UK’s research grant to continue his specialist studies into examining how the accumulation of mutated proteins in certain blood cancer cells allows them to multiply repeatedly.
[Charity Today] |
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| March 24 – 25, 2021
Virtual |
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| | University of York – York, England, United Kingdom |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | Blood Research Institute – Milwaukee, Wisconsin, United States |
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