 | | Vol. 12.07 – 9 March, 2021 |
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| Researchers quantified the effect of the JAK2-V617F mutation on the self-renewal and differentiation dynamics of HSCs in treatment-naive individuals with myeloproliferative neoplasms and reconstructed lineage histories of individual HSCs using somatic mutation patterns.
[Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Thpo-/- HSCs exhibited profound loss of quiescence, impaired cell cycle progression and increased apoptosis. Thpo-/- HSCs also exhibited diminished mitochondrial mass and impaired mitochondrial bioenergetics.
[Blood] |
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| OTS167 alone or in combination with tyrosine kinase inhibitors were used to investigate the effect of OTS167 on FLT3 signaling and expression in human Fms-like tyrosine kinase 3 (FLT3) mutant acute myeloid leukemia cell lines and primary cells.
[Blood Cancer Journal] |
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| Investigators generated an Apelin receptor (Aplnr)-tdTomato reporter mouse embryonic stem cell line and showed that hematopoietic stem and progenitor cells were generated exclusively from mesodermal cells that express Aplnr-tdTomato.
[Stem Cell Reports] |
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| The relative expression of LINC00665, miR-4458 and DOCK1 in acute myeloid leukemia (AML) samples was measured using qRT-PCR, and the protein level of DOCK1 in AML cell lines was examined using western blot.
[Scientific Reports] |
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| Plasma tissue factor pathway inhibitor concentrations were measured by ELISA. Chronic lymphocytic leukemia cells were isolated from patients and used for trans-endothelial migration assays.
[Scientific Reports] |
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| Scientists demonstrate that mice lacking CD74 exhibited an accumulation of HSCs in the bone marrow (BM) due to their increased potential to repopulate and compete for BM niches.
[PLoS One] |
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| Researchers present findings from longitudinal whole-exome sequencing of multiply relapsed CLL patients enrolled in phosphatidylinositol 3-kinase delta (PI3Ki) trials. The non-responder subgroup was characterized by baseline activating mutations in MAP2K1, BRAF and KRAS in 60% of patients.
[Blood] |
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| Scientists report the discovery of a CIP2Asplicing variant, NOCIVA. Characterization of CIP2A variants was performed by both 3′ and 5′ rapid amplification of cDNA ends from cancer cells.
[Clinical Cancer Research] |
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| Investigators determined whether substituting blinatumomab for intensive chemotherapy in consolidation therapy would improve survival in children, adolescents, and young adults with high- and intermediate-risk first relapse of B-cell acute lymphoblastic leukemia (B-ALL).
[JAMA Network Open] |
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| The authors describe the spectrum of genetic aberrations detected in DCL cases in the literature with regard to the character of the individual cases, existing family cohorts that carry individual genes, and functional studies that support etiologic roles in acute myelogenous leukemia development.
[Bone Marrow Transplantation] |
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| Infection with coronaviruses sometimes leads to hematologic complications in patients, and these hematologic complications are associated with poorer prognosis.
[Current Opinion in Hematology] |
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| Kite, a Gilead Company announced that the FDA has granted accelerated approval to Yescarta® for the treatment of adult patients with relapsed or refractory follicular lymphoma after two or more lines of systemic therapy.
[Gilead Sciences, Inc.] |
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| US Congressman Donald Norcross announced that the Coriell Institute for Medical Research, located in Camden, has been awarded a $408,617 grant from the National Cancer Institute. This grant will go towards a research project aimed at exploring drug resistance in patients with acute myeloid leukemia.
[Donald Norcross] |
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| June 18 – 22, 2021
Virtual |
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| | Cleveland Cord Blood Center – Cleveland, Ohio, United States |
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| | Houston Methodist Research Institute – Houston, Texas, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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