| Vol. 12.08 – 16 March, 2021 |
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| Hectd1-deficient HSCs exhibited a striking defect in transplantation ability and ex vivo maintenance concomitant with reduced protein synthesis and growth rate under stress conditions. [Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors demonstrated using an immune-competent mouse model of B cell acute lymphoblastic leukemia that Regnase-1 deficiency promoted TCF-1 expression to enhance CAR-T cell expansion and memory-like cell formation. [Blood] |
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| Investigators characterized patients with acute myeloid leukemia with plasmacytoid dendritic cells (pDC) expansion, which they observed in ∼5% of AML cases. pDC-AMLs often possessed cross-lineage antigen expression and have adverse risk stratification with poor outcome. [Blood] |
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| Transplantation of HSCs transduced with lentiviral vector expressing green florescent protein into lethally irradiated recipient mice was followed by intracranial implantation of glioblastoma cells. [Journal For Immunotherapy of Cancer] |
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| Zrsr2-deficient mice developed normal hematopoiesis with no abnormalities in myeloid differentiation evident in either young or ≥one-year old knockout mice. [Haematologica] |
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| The authors identified the molecular mechanism of Sonic hedgehog (Shh)-mediated mutation-independent Imatinib resistance that is most relevant for treating chronic myeloid leukemia-variants and non-compliant patients. [Cell Death & Disease] |
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| Investigators established conditionally immortalized myeloid progenitor cell lines co-expressing constitutive Hoxa9.EGFP and inducible Meis1.dTomato to study growth behavior, immunophenotype and morphology under different cytokine/microenvironmental conditions ex vivo upon doxycycline induction or removal. [Scientific Reports] |
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| Researchers describe a novel strategy for establishing a zebrafish model for drug testing in leukemia xenografts. They used chronic myelogenous leukemia and acute myeloid leukemia for xenotransplantation into severe combined immunodeficiency zebrafish to evaluate drug screening protocols. [Scientific Reports] |
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| The authors report that trisomy 12 (tri12) human pluripotent stem cells (PSCs) allowed for the identification of gene networks and targets specific to tri12, which are controlled by comparative normal PSCs. [Cell Reports] |
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| Scientists argue that understanding the epigenetic (dys)regulation in T cells of chronic lymphocytic leukemia patients should be leveled to the knowledge we currently have of the neoplastic B cells themselves. [Haematologica] |
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| | Bluebird Bio, Inc. announced that based on the analyses completed to date, it is very unlikely the Suspected Unexpected Serious Adverse Reaction of AML reported in its Phase I/II study of LentiGlobin gene therapy for SCD was related to the BB305 lentiviral vector. [Bluebird Bio, Inc.] |
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| Children’s Cancer Research Fund is proud to award $10.5 million in its latest round of funding. The new grants support 12 research organizations that are working to improve treatment and outcomes for children and adolescents with cancer. [Children’s Cancer Research Fund] |
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| City of Hope – Los Angeles, California, United States |
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| University of Michigan – Ann Arbor, Michigan, United States |
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| Cleveland Cord Blood Center – Cleveland, Ohio, United States |
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| Houston Methodist Research Institute – Houston, Texas, United States |
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| Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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