Hematopoiesis News Volume 12.09 | Mar 16 2021

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    2021-03-16 | HEMA 12.08


    Hematopoiesis News by STEMCELL Technologies
    Vol. 12.08 – 16 March, 2021
    TOP STORY

    HectD1 Controls Hematopoietic Stem Cell Regeneration by Coordinating Ribosome Assembly and Protein Synthesis

    Hectd1-deficient HSCs exhibited a striking defect in transplantation ability and ex vivo maintenance concomitant with reduced protein synthesis and growth rate under stress conditions.
    [Cell Stem Cell]

    AbstractGraphical Abstract
    Image of erythroblasts which were simply & efficiently generated from PSCs using the STEMdiff Erythroid Kit.
    PUBLICATIONSRanked by the impact factor of the journal

    Regnase-1 Suppresses TCF-1+ Precursor Exhausted T Cell Formation to Limit CAR T Cell Responses against ALL

    The authors demonstrated using an immune-competent mouse model of B cell acute lymphoblastic leukemia that Regnase-1 deficiency promoted TCF-1 expression to enhance CAR-T cell expansion and memory-like cell formation.
    [Blood]

    Abstract

    Plasmacytoid Dendritic Cell Expansion Defines a Distinct Subset of RUNX1-Mutated Acute Myeloid Leukemia

    Investigators characterized patients with acute myeloid leukemia with plasmacytoid dendritic cells (pDC) expansion, which they observed in ∼5% of AML cases. pDC-AMLs often possessed cross-lineage antigen expression and have adverse risk stratification with poor outcome.
    [Blood]

    Abstract

    Hematopoietic Stem Cell Gene Therapy Targeting TGFβ Enhances the Efficacy of Irradiation Therapy in a Preclinical Glioblastoma Model

    Transplantation of HSCs transduced with lentiviral vector expressing green florescent protein into lethally irradiated recipient mice was followed by intracranial implantation of glioblastoma cells.
    [Journal For Immunotherapy of Cancer]

    Full Article

    ZRSR1 Cooperates with ZRSR2 in Regulating Splicing of U12-Type Introns in Murine Hematopoietic Cells

    Zrsr2-deficient mice developed normal hematopoiesis with no abnormalities in myeloid differentiation evident in either young or ≥one-year old knockout mice.
    [Haematologica]

    Abstract

    Exovesicular-Shh Confers Imatinib Resistance by Upregulating Bcl2 Expression in Chronic Myeloid Leukemia with Variant Chromosomes

    The authors identified the molecular mechanism of Sonic hedgehog (Shh)-mediated mutation-independent Imatinib resistance that is most relevant for treating chronic myeloid leukemia-variants and non-compliant patients.
    [Cell Death & Disease]

    Abstract

    Conditionally Immortalized Leukemia Initiating Cells Co-Expressing Hoxa9/Meis1 Demonstrate Microenvironmental Adaptation Properties Ex Vivo while Maintaining Myelomonocytic Memory

    Investigators established conditionally immortalized myeloid progenitor cell lines co-expressing constitutive Hoxa9.EGFP and inducible Meis1.dTomato to study growth behavior, immunophenotype and morphology under different cytokine/microenvironmental conditions ex vivo upon doxycycline induction or removal.
    [Scientific Reports]

    Full Article

    Targeted Therapy of Human Leukemia Xenografts in Immunodeficient Zebrafish

    Researchers describe a novel strategy for establishing a zebrafish model for drug testing in leukemia xenografts. They used chronic myelogenous leukemia and acute myeloid leukemia for xenotransplantation into severe combined immunodeficiency zebrafish to evaluate drug screening protocols.
    [Scientific Reports]

    Abstract

    Human Pluripotent Stem Cells Identify Molecular Targets of Trisomy 12 in Chronic Lymphocytic Leukemia Patients

    The authors report that trisomy 12 (tri12) human pluripotent stem cells (PSCs) allowed for the identification of gene networks and targets specific to tri12, which are controlled by comparative normal PSCs.
    [Cell Reports]

    Full Article

    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    REVIEWS

    T-Cell Dysfunction in Chronic Lymphocytic Leukemia from an Epigenetic Perspective

    Scientists argue that understanding the epigenetic (dys)regulation in T cells of chronic lymphocytic leukemia patients should be leveled to the knowledge we currently have of the neoplastic B cells themselves.
    [Haematologica]

    Abstract
    INDUSTRY AND POLICY NEWS

    Bluebird Bio Provides Updated Findings from Reported Case of Acute Myeloid Leukemia (AML) in LentiGlobin for Sickle Cell Disease (SCD) Gene Therapy Program

    Bluebird Bio, Inc. announced that based on the analyses completed to date, it is very unlikely the Suspected Unexpected Serious Adverse Reaction of AML reported in its Phase I/II study of LentiGlobin gene therapy for SCD was related to the BB305 lentiviral vector.
    [Bluebird Bio, Inc.]

    Graphical Abstract

    Children’s Cancer Research Fund Announces $10.5 Million in New Grants to Accelerate Childhood Cancer Research

    Children’s Cancer Research Fund is proud to award $10.5 million in its latest round of funding. The new grants support 12 research organizations that are working to improve treatment and outcomes for children and adolescents with cancer.
    [Children’s Cancer Research Fund]

    Press Release
    FEATURED EVENT

    6th Annual Arizona Cord Blood Conference: Bridging the Gap

    April 22, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Oncogenesis in Blood Malignancies

    City of Hope – Los Angeles, California, United States

    Postdoctoral Fellow Position – Collagen Receptors in Bone Development and Regeneration

    University of Michigan – Ann Arbor, Michigan, United States

    Associate Researcher – Umbilical Cord Blood Therapeutics

    Cleveland Cord Blood Center – Cleveland, Ohio, United States

    Postdoctoral Fellow – Myeloid-Derived Suppressor Cells

    Houston Methodist Research Institute – Houston, Texas, United States

    Postdoctoral Position – Hematopoietic Development

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    > See All Jobs

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