LABORATORY RESEARCH Whole-Genome Sequencing Identifies Recurrent Mutations in Chronic Lymphocytic Leukemia Scientists performed whole-genome sequencing of four cases of chronic lymphocytic leukemia and identified 46 somatic mutations that potentially affect gene function. [Nature] Functional Crosstalk Between Bmi1 and MLL/Hoxa9 Axis in Establishment of Normal Hematopoietic and Leukemic Stem Cells In this study, researchers investigated whether leukemia-associated fusion proteins could initiate leukemia in the absence of Bmi1. [Cell Stem Cell] Wnt-Inhibitory Factor 1 Dysregulation of the Bone Marrow Niche Exhausts Hematopoietic Stem Cells Investigators reported that osteoblastic Wnt inhibitory factor 1 over-expression disrupts stem cell quiescence leading to a loss of self-renewal potential. [Blood] Il-7 Mediates Ebf-1–Dependent Lineage Restriction in Early Lymphoid Progenitors In order to understand more about how Il-7 deficiency impacts early lymphoid development, scientists have investigated lineage restriction events within the common lymphoid progenitor compartment in Il-7 knockout mice. [Blood] Irgm1 Protects Hematopoietic Stem Cells by Negative Regulation of Interferon Signaling To investigate the molecular basis for these defects, researchers conducted microarray expression profiling of Irgm1-deficient hematopoietic stem cells. [Blood] FLT3 Expression Initiates in Fully Multipotent Mouse Hematopoietic Progenitor Cells Investigators demonstrated that mouse Flt3 expression initiates in fully multipotent progenitors, as not only lymphoid and granulocyte-monocyte progenitors, but also FLT3– Mk and E restricted downstream progenitors are highly labeled when applying Flt3-Cre fate mapping. [Blood] Neurexophilin 1 Suppresses the Proliferation of Hematopoietic Progenitor Cells Results demonstrate the presence and function of a regulated signaling axis in hematopoiesis centered on Neurexin I α and its modulation by dystroglycan and neurexophilin 1. [Blood] Mechanisms of Cytotoxicity to Pim Kinase Inhibitor, SGI-1776, in Acute Myeloid Leukemia Pim are ser/thr kinases with multiple substrates that affect survival pathways. These proteins are overexpressed in acute myeloid leukemia (AML) blasts and scientists hypothesized that Pim kinase inhibition would affect AML cell survival. [Blood] MiR-17/20/93/106 Promote Hematopoietic Cell Expansion by Targeting Sequestosome 1-Regulated Pathways in Mice Researchers show that ectopic expression of miR-17,-20,-93 and -106 increases proliferation, colony outgrowth and replating capacity of myeloid progenitors and results in enhanced P-ERK levels. [Blood] MiR-100 Regulates Cell Differentiation and Survival by Targeting RBSP3, a Phosphatase-Like Tumor Suppressor in Acute Myeloid Leukemia Data highlights an important role of microRNA-100 (miR-100) in the molecular etiology of acute myeloblastic leukemia, and implicate the potential application of miR-100 in cancer therapy. [Oncogene] CLINICAL RESEARCH Long-Term Health-Related Outcomes in Survivors of Childhood Cancer Treated with Hematopoietic Cell Transplantation (HCT) Versus Conventional Therapy: A Report from the Bone Marrow Transplant Survivor Study and Childhood Cancer Survivor Study Scientists compared the risk of chronic health conditions and adverse health among children with cancer treated with HCT, with survivors treated conventionally, as well as with sibling controls. [Blood] Influence of Immunosuppressive Treatment on Risk of Recurrent Malignancy after Allogeneic Hematopoietic Cell Transplantation This study was conducted to elucidate the influence of immunosuppressive treatment and graft-versus-host disease on risk of recurrent malignancy after allogeneic hematopoietic cell transplantation. [Blood] IDH1 and IDH2 Mutations in Pediatric Acute Leukemia To investigate the frequency of isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) mutations in pediatric acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), investigators sequenced these genes in diagnostic samples from 515 patients (227 AMLs and 288 ALLs). [Leukemia] |