Hematopoiesis News Volume 2.27 | Jul 12 2011

LABORATORY RESEARCH

Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment
By tracking the expression of several adhesion molecules in hematopoietic stem cell (HSC)-enriched subsets, researchers revealed CD49f as a specific HSC marker. [Science]

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
Results provided compelling support for DOT1L inhibition as a basis for targeted therapeutics against mixed lineage leukemia. [Cancer Cell]

MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L
Investigators identified the mixed lineage leukemia (MLL)-fusion targets in an MLL-AF9 leukemia model, and conducted epigenetic profiling for H3K79me2, H3K4me3, H3K27me3, and H3K36me3 in hematopoietic progenitor and leukemia stem cells. [Cancer Cell]

The Histone Methyltransferase Inhibitor DZNep Upregulates TXNIP, Increases Reactive Oxygen Species Production, and Targets Leukemia Cells in AML
Study demonstrated that 3-Deazaneplanocin A (DZNep) induces robust apoptosis in acute myeloid leukemia (AML) cell lines, primary cells, and targets CD34⁺CD38^– leukemia stem cell-enriched subpopulations. [Blood]

Accumulation of Oxidative DNA Damage Restricts the Self-Renewal Capacity of Human Hematopoietic Stem Cells
Scientists demonstrated that the serial transplantation of human hematopoietic stem cells (HSCs) into immunodeficient mice triggers replication stress that induces incremental elevation of intracellular reactive oxygen species levels and the accumulation of persistent DNA damage within the human HSCs. [Blood]

Prolonged Self-Renewal Activity Unmasks Telomerase Control of Telomere Homeostasis and Function of Mouse Hematopoietic Stem Cells
Investigators examined the impact of hematopoietic stem cell (HSC) self-renewal divisions in-vitro and in-vivo on their subsequent regenerative and continuing ability to sustain blood cell production in the absence of telomerase. [Blood]

Efficient Hematopoietic Redifferentiation of Induced Pluripotent Stem Cells Derived from Primitive Murine Bone Marrow Cells
Scientists generated iPSCs from primitive and non-adherent differentiated bone marrow cells, and compared their differentiation potential to that of fibroblast-derived iPSCs and ESCs. [Stem Cells Dev]

The Non-Steroidal Anti-Inflammatory Drugs Sulindac Sulfide and Diclofenac Induce Apoptosis and Differentiation in Human Acute Myeloid Leukemia Cells through an AP-1 Dependent Pathway
In this study, a total number of 42 bone marrow derived CD34⁺ selected de novo acute myeloid leukemia (AML) patient samples and the AML cell lines THP-1 and HL-60 were treated with the non-steroidal anti-inflammatory drugs sulindac sulfide and diclofenac. [Apoptosis]

CLINICAL RESEARCH

In Vitro Efficacy of Forodesine and Nelarabine (Ara-G) in Pediatric Leukemia
To better understand which pediatric patients might benefit from ara-G therapy, scientists investigated the in-vitro sensitivity to these drugs in 96 diagnostic pediatric leukemia patient samples and the mRNA expression levels of different enzymes involved in nucleoside metabolism. [Blood]

Reduced-Intensity Conditioning Therapy with Busulfan, Fludarabine, and Anti-Thymocyte Globulin for HLA-Haploidentical Hematopoietic Cell Transplantation in Acute Leukemia and Myelodysplastic Syndrome
Investigators assessed 83 patients (age, 16-70 years), 68 with acute leukemia, including 34 in remission and 34 with refractory disease; and 15 patients with myelodysplastic syndrome, in hematopoietic cell transplantation trials utilizing reduced-intensity conditioning with busulfan, fludarabine, and anti-thymocyte globulin. [Blood]

Accurate Targeting of Daily Intravenous Busulfan with 8-Hour Blood Sampling in Hospitalized Adult Hematopoietic Cell Transplant Recipients
A retrospective pharmacokinetic analysis was conducted in 87 adults receiving daily intravenous busulfan doses administered at the traditional frequency of every 6 hours (^TBU) as part of cyclophosphamide followed by ^TBU, fludarabine monophosphate followed by ^TBU, or ^TBU concurrent with fludarabine conditioning. [Biol Blood Marrow Transplant]

The Leukemia & Lymphoma Society Awards $10.2 Million in Research Grants in Four Areas of Critical Unmet Need
The Leukemia & Lymphoma Society announced the awarding of 17 grants in response to the RFPs under its Translational Research Program, a program designed to help accelerate the movement of promising discoveries from the lab to the clinic. [Leukemia & Lymphoma Society Press Release]

Researchers Receive Grants from NCCN Oncology Research Program Funded through Pfizer
The National Comprehensive Cancer Network (NCCN) Oncology Research Program received $2.1 million in research funding from Pfizer, Inc. to support research at NCCN Member Institutions in order to gain further insight into the use of axitinib in various tumor types. [National Comprehensive Cancer Network Press Release]

Ching-Hon Pui, M.D., Honored by the American Society of Hematology for Contributions to Childhood Cancer Treatment
Ching-Hon Pui, M.D. has been named the recipient of the 2011 Henry M. Stratton Medal from the American Society of Hematology. [St. Jude Children’s Research Hospital Press Release]

August 2-3, 2011: Blood Products Advisory Committee Meeting Announcement (Center for Biologics Evaluation and Research, United States)

August 2-3, 2011: Blood Products Advisory Committee Meeting Waivers for Conflicts of Interest (Center for Biologics Evaluation and Research, United States)

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW 4th Annual Stem Cells Europe
July 20-21, 2011
Edinburgh, Scotland

NEW Cancer Research Global Summit
August 16-17, 2011
London, United Kingdom

Visit our events page to see a complete list of events in the hematopoietic community

Post Doctoral Fellow (MedImmune)

Laboratory Project Scientist (University of California, San Diego)

Recruit Top Talent

Reach more than 11,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Jobs are categorized regionally: United States, Canada, Europe, Asia Pacific

Visit here to post your career opportunities.

Have we missed an important article or publication in Hematopoiesis News? Click here to submit!

Comments or Suggestions? Email info@connexoncreative.com with your feedback.