Hematopoiesis News Volume 2.40 | Oct 11 2011

LABORATORY RESEARCH

Canonical Wnt Signaling Regulates Hematopoiesis in a Dosage-Dependent Fashion
To investigate whether canonical Wnt signaling regulates hematopoiesis in a dosage-dependent fashion, researchers analyzed the effect of different mutations in the Adenomatous polyposis coli gene, a negative modulator of the canonical Wnt pathway. [Cell Stem Cell] Abstract

The Ribosome-Related Protein, SBDS, Is Critical for Normal Erythropoiesis
Investigators asked whether SBDS, which is mutated in most Shwachman-Diamond syndrome patients, is critical for erythroid development. [Blood] Abstract

Effect of Nucleophosmin1 Haploinsufficiency on Hematopoietic Stem Cells
Mice genetically engineered to harbor heterozygous loss of nucleophosmin1 were shown to have a mild myelodysplastic syndrome-like phenotype characterized by dyserythropoiesis and dysplastic megakaryocytes with macrocytic anemia, but without significant cytopenias or alterations in lineage commitment. [Leukemia] Abstract

Impaired Functionality and Homing of Fancg-Deficient Hematopoietic Stem Cells
Scientists have examined the role of the nuclear Fanconi Anemia core complex gene Fancg in the functionality of hematopoietic stem cells. [Hum Mol Genet] Abstract

MicroRNA-150-Regulated Vectors Allow Lymphocyte-Sparing Transgene Expression in Hematopoietic Gene Therapy
Here, researchers have investigated the potential of microRNA-150 target sequences to specifically suppress gene expression in lymphocytes and thereby prevent transgene-induced lymphotoxicity. [Gene Ther] Abstract

CLINICAL RESEARCH

Induced Immune Tolerance for Kidney Transplantation
In the current proof-of-concept study, 12 patients who received HLA-matched kidney transplants received a donor-cell infusion of highly enriched CD34⁺ hematopoietic progenitor cells mixed with CD3⁺ T cells, and a conditioning regimen of total lymphoid irradiation and anti–T-cell antibodies according to a protocol described in detail in a previous case report of the successful induction of tolerance. [N Engl J Med] Abstract | Press Release

Phase I/II Study to Assess the Safety, Efficacy, and Pharmacokinetics of Barasertib (AZD1152) in Patients with Advanced Acute Myeloid Leukemia
The primary objective of this Phase I/II two-part study was to determine the maximum-tolerated dose of the potent and selective Aurora B kinase inhibitor barasertib, in patients with newly diagnosed or relapsed acute myeloid leukemia. [Blood] Abstract

Favorable Outcome in Infants with AML After Intensive First- and Second-Line Treatment: An AML-BFM Study Group Report
Data indicates that intensive frontline and relapse acute myeloid leukemia (AML) treatment is feasible in infants, toxicities are manageable, and outcome is favorable. [Leukemia] Abstract

ISBT Bar Code Labeling System for Cellular Therapy
Digi-Trax® Corporation and STEMSOFT™ Software Inc. are pleased to announce that they will jointly work together to develop an integrated solution that connects the industry’s leading cell therapy laboratory software system, StemLab™, with Digi-Trax’s flagship Hema-Trax®-CT labeling solution. [STEMSOFT™ Software Inc.] Press Release

The Japanese Cancer Association (JCA) and Debiopharm Group™ Present Doctors Arakawa and Kurokawa with the 2011 ‘JCA-Mauvernay Award’ for their Innovative and Outstanding Research in the Field of Cancer
Debiopharm Group™ presented the ‘JCA-Mauvernay Award’ to Doctor Hirofumi Arakawa from the National Cancer Center Research Institute in Tokyo, for his basic research on the ‘identification and characterization of p53 target genes’ and to Doctor Mineo Kurokawa from the University of Tokyo, for his applied research on ‘the molecular pathogenesis and therapeutic targets of hematological malignancies’. [Debiopharm Group™] Press Release

Coffield Joins Biology Department
Dr. Vernon M. Coffield recently joined High Point University as a visiting assistant professor of biology. [High Point University] Press Release

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW American Association for Cancer Research Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy
November 3-6, 2011
Orlando, United States

Visit our events page to see a complete list of events in the hematopoietic community

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Postdoctoral Fellows – Blood Systems Research Institute (University of California, San Francisco)

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