Hematopoiesis News Volume 2.42 | Oct 25 2011

Polymeric IgA1 Controls Erythroblast Proliferation and Accelerates Erythropoiesis Recovery in Anemia
Scientists show that, when cultured with erythropoietin at suboptimal concentrations, the growth and clonogenic potential of erythroblasts was rescued by transferrin receptor 1-bound polymeric IgA1. [Nat Med] Abstract

The Ability of MLL to Bind RUNX1 and Methylate H3K4 at PU.1 Regulatory Regions Is Impaired by MDS/AML-Associated RUNX1/AML1 Mutations
Investigators have identified a physical and functional interaction between RUNX1 (AML1) and Mixed-Lineage Leukemia (MLL) and show that both are required to maintain the histone lysine 4 trimethyl mark at two critical regulatory regions of the AML1 target gene PU.1. [Blood] Abstract

AML1/RUNX1 Functions as a Cytoplasmic Attenuator of NF-κB Signaling in the Repression of Myeloid Tumors
Here scientists explored immediate target pathways of AML1 by in vitro synchronous inactivation in hematopoietic cells. [Blood] Abstract

Short Telomeres Result in Chromosomal Instability in Hematopoietic Cells and Precede Malignant Evolution in Human Aplastic Anemia
Here researchers directly implicate telomere shortening as a critical molecular event for malignant evolution in aplastic anemia. [Leukemia] Abstract

The Transcriptional Coactivator Cbp Regulates Self-Renewal and Differentiation in Adult Hematopoietic Stem Cells
Here, investigators demonstrate a gradual loss of phenotypic hematopoietic stem cells and differentiation defects following conditional ablation of Cbp during adult homeostasis. [Mol Cell Biol] Abstract

miR-590-5p, miR-219-5p, miR-15b and miR-628-5p Are Commonly Regulated by IL-3, GM-CSF and G-CSF in Acute Myeloid Leukemia
Using real-time PCR-based miRNA expression profiling, scientists investigated miRNA signatures regulated by IL-3, GM-CSF and G-CSF for n = 704 miRNAs. [Leuk Res] Abstract

CLINICAL RESEARCH

No Difference in Outcome Between Children and Adolescents Transplanted for Acute Lymphoblastic Leukemia in Second Remission
Researchers compared the outcome after hematopoietic stem cell transplantation of adolescents, aged 14-18 years, with that of children (i.e. patients younger than 14 years). [Blood] Abstract

High Concordance of Subtypes of Childhood Acute Lymphoblastic Leukemia within Families: Lessons from Sibships with Multiple Cases of Leukemia
Data indicate strong genetic and/or environmental risk factors for childhood acute lymphoblastic leukemia (ALL) that are restricted to specific ALL subtypes, which must be taken into account, when performing epidemiological studies to reveal etiological factors. [Leukemia] Abstract

Phase I Study of Topotecan, Ifosfamide, and Etoposide with Autologous Stem Cell Transplant in Refractory Cancer: Pharmacokinetic and Pharmacodynamic Correlates
The purpose of this study is to determine the maximum tolerated dose of topotecan in combination with ifosfamide, mesna, and etoposide, followed by autologous hematopoietic cell transplant, in patients with chemotherapy-refractory malignancies. [Clin Cancer Res] Abstract

Babraham Announced as Partner in €30 Million European Project to Decipher the Epigenome
Researchers from the Babraham Institute’s Epigenetics Laboratories are partners in an exciting new initiative, launched this month by the health-research division of the European Commission with an investment of €30-million. [Babraham Institute] Press Release

CaridianBCT and Terumo Transfusion Unveil New Milestones in Progress Toward Becoming Terumo BCT at AABB Annual Meeting & CTTXPO 2011
CaridianBCT and Terumo Transfusion unveiled that they are uniting to become Terumo BCT, the world leader in blood component technology, products and services in the blood banking, transfusion medicine and cell therapy industries. [BusinessWire] Press Release

Therapeutic Goods Administration (Australia)

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Postdoctoral Position – Regulation of Hematopoiesis by Extrinsic Regulators (Stem Cell Center Lund University)

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