Hematopoiesis News Volume 2.43 | Nov 1 2011

Lineage Regulators Direct BMP and Wnt Pathways to Cell-Specific Programs during Differentiation and Regeneration
BMP and Wnt signaling pathways control essential cellular responses through activation of the transcription factors SMAD (BMP) and TCF (Wnt). Here, researchers show that regeneration of hematopoietic lineages following acute injury depends on the activation of each of these signaling pathways to induce expression of key blood genes. [Cell] Abstract

Regulation of Murine Hematopoietic Stem Cell Quiescence by Cyclin D Binding Myb-Like Transcription Factor-1, Dmtf1
Here investigators demonstrate that cyclin-D binding myb-like transcription factor1 (Dmtf1) regulates hematopoietic stem cell function under both steady state and stress conditions. [Blood] Abstract

Dual Functions of Cell-Autonomous and Non-Cell-Autonomous ADAM10 Activity in Granulopoiesis
Scientists show that conditional inactivation of ADAM10, a membrane-bound protease with a crucial role in Notch signaling (S2 cleavage), results in myeloproliferative disorder highlighted by severe splenomegaly and increased populations of myeloid cells and hematopoietic stem cells. [Blood] Abstract

Dependency on the Polycomb Gene Ezh2 Distinguishes Fetal from Adult Hematopoietic Stem Cells
Here researchers show that Ezh2, a core component of Polycomb repressive complex 2, is essential for fetal but not adult hematopoietic stem cells. [Blood] Abstract

The Redox-Sensitive Transcription Factor, Nrf2, Regulates Murine Hematopoietic Stem Cell Survival Independent of Reactive Oxygen Species Levels
Investigators have studied the role of Nrf2, a master regulator of the anti-oxidant response, and found that Nrf2 is required for hematopoietic stem progenitor cell survival and myeloid development. [Blood] Abstract

E4F1 Dysfunction Results in Autophagic Cell Death in Myeloid Leukemic Cells
Using a genetically engineered mouse model of myeloid leukemia (histiocytic sarcomas) based on the genetic inactivation of the tumor suppressor Ink4a/Arf locus, scientists have recently unraveled an unsuspected function of E4F1 in the survival of leukemic cells. [Autophagy] Abstract

DEK Regulates Hematopoietic Stem Engraftment and Progenitor Cell Proliferation
Researchers hypothesized that DEK may modulate functions of hematopoietic stem and progenitor cells. [Stem Cells Dev] Abstract

CLINICAL RESEARCH

ASXL1 Mutations Identify a High-Risk Subgroup of Older Patients with Primary Cytogenetically Normal Acute Myeloid Leukemia within the European LeukemiaNet “Favorable” Genetic Category
Investigators analyzed 423 adult patients for ASXL1 mutations, other prognostic gene mutations, and gene-/microRNA-expression profiles. [Blood] Abstract

Hematopoietic Cell Transplantation for Primary Plasma Cell Leukemia: Results from the Center for International Blood and Marrow Transplant Research
Scientists report outcomes of 147 patients with primary plasma cell leukemia receiving autologous (n=97) or allogeneic (n=50) hematopoietic cell transplantation within 18 months after diagnosis between 1995 and 2006. [Leukemia] Abstract

Safety, Efficacy and Biological Predictors of Response to Sequential Azacitidine and Lenalidomide for Elderly Patients with Acute Myeloid Leukemia
In this phase-I study, researchers determined the maximum tolerated dose and the efficacy for sequential azacitidine and lenalidomide as remission induction and continuation therapy in elderly, previously untreated patients. [Leukemia] Abstract

A New Hope for Patients with HIV
When an HIV-positive patient with leukemia received an experimental hematopoietic stem cell therapy to treat his cancer, something surprising occurred: the treatment also removed all traces of HIV from his blood. [Press release from the American Association of Blood Banks (AABB) discussing research presented at the AABB Annual Meeting & CTTXPO 2011, San Diego] Press Release

La Jolla Institute Joins Sanford Consortium for Regenerative Medicine
The La Jolla Institute for Allergy & Immunology has become the fifth organization in the prestigious Sanford Consortium for Regenerative Medicine, joining colleagues from the Salk Institute for Biological Studies, The Scripps Research Institute, University of California, San Diego and the Sanford-Burnham Medical Research Institute in the first-of-its-kind multi-institutional stem cell research collaboration. [La Jolla Institute for Allergy & Immunology] Press Release

Tech Entrepreneur Offers Grants for Indie Science
Breakout Labs is offering grants to independent researchers working on “radical” ideas. [ScienceInsider] Press Release

Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the hematopoietic community

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Research and Development Technologist, hPSC Media (STEMCELL Technologies)

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Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Postdoctoral Position (National Taiwan University)

Postdoctoral Fellow – Hematopoietic Stem Cells (City of Hope)

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