Hematopoiesis News Volume 2.46 | Nov 22 2011

Low BCR-ABL Expression Levels in Hematopoietic Precursor Cells Enable Persistence of Chronic Myeloid Leukemia Under Imatinib
Researchers have shown, that the number of BCR-ABL positive precursors decreases significantly in all bone marrow compartments during major molecular remission. [Blood] Abstract

Silencing of ETV6/RUNX1 Abrogates PI3K/AKT/mTOR Signaling and Impairs Reconstitution of Leukemia in Xenografts
Scientists suppressed the endogenous ETV6/RUNX1 fusion protein with lentivirally transduced short hairpin RNA in the leukemia cell lines REH and AT-2, and found a distinct reduction of proliferation and cell survival. [Leukemia] Abstract

A Non-Canonical Flt3ITD/ NF-κB Signaling Pathway Represses DAPK1 in Acute Myeloid Leukemia (AML)
A mechanistic basis for epigenetic/transcriptional repression of DAPK1 was investigated in certain forms of AML with poor prognosis, which lacked ER stress-induced apoptosis. [Clin Cancer Res] Abstract

Apigenin Induces Apoptosis in Human Leukemia Cells and Exhibits Anti-Leukemic Activity In Vivo via Inactivation of Akt and Activation of JNK
In this study, researchers investigated the functional role of Akt and JNK signaling cascades in apigenin-induced apoptosis in U937 human leukemia cells and anti-leukemic activity of apigenin in vivo. [Clin Cancer Res] Abstract

Genomic c-Myc Quadruplex DNA Selectively Kills Leukemia
Investigators show that treatment of leukemia with an oligonucleotide encoding the genomic PU27 sequence induces cell cycle arrest and death by oncotic-necrosis due to PU27-mediated suppression of c-myc mRNA/protein expression. [Mol Cancer Ther] Abstract

JmjC-Domain Containing Histone Demethylase 1B-Mediated p15Ink4b Suppression Promotes the Proliferation of Leukemic Progenitor Cells through Modulation of Cell Cycle Progression in Acute Myeloid Leukemia
In this study, scientists investigated the cellular and molecular function of JHDM1B in acute myeloid leukemia cells. [Mol Carcinog] Abstract

The Triterpenoid CDDO-Me Promotes Hematopoietic Progenitor Expansion and Myelopoiesis in Mice
In the current study, researchers observed that CDDO-Me promoted myelopoiesis in both naïve and transplanted mice. [Biol Blood Marrow Transplant] Abstract

Homeostasis of Hematopoietic Stem Cells Regulated by the Myeloproliferative Disease Associated-Gene Product Lnk/Sh2b3 via Bcl-xL
Here, investigators demonstrate that upon stimulation with thrombopoietin, the expression of Bcl-xL was highly enhanced in Lnk-deficient hematopoietic stem cells (HSCs) compared to normal HSCs. [Exp Hematol] Abstract

CLINICAL RESEARCH

Monosomal Karyotype in Adult Acute Myeloid Leukemia: Prognostic Impact and Outcome After Different Treatment Strategies
The objectives of this study is to determine the prognostic impact of monosomal karyotype (MK) in acute myeloid leukemia in the context of the current World Health Organization classification and to evaluate the outcome of MK⁺ patients after allogeneic hematopoietic stem cell transplantation. [Blood] Abstract

A Genome-Wide Meta-Analysis of Nodular Sclerosis Hodgkin Lymphoma Identifies Risk Loci at 6p21.32
Scientists undertook a genome-wide meta-analysis of 393 European-origin adolescent/young adult nodular sclerosing Hodgkin lymphoma patients and 3,245 controls using the Illumina Human610-Quad Beadchip and Affymetrix Genome-Wide Human SNP Array 6.0. [Blood] Abstract

RNL Opens the World’s Largest Stem Cell Medical Center in Beijing, China
RNL BIO, South Korea’s premier adult stem cell firm, has just founded the world’s largest stem cell medical center in Beijing, China. [PR Newswire] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral Position – Center for Human Genetics (VIB Research Institute)

Postgraduate Students (Masaryk University)

Research Postdoctoral Position (National Taiwan University)

Postdoctoral Fellow – Hematopoietic Stem Cells (City of Hope)

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