LABORATORY RESEARCH Lin28b Reprograms Adult Bone Marrow Hematopoietic Progenitors to Mediate Fetal-Like Lymphopoiesis Scientists demonstrate that ectopic expression of Lin28 reprograms hematopoietic stem–progenitor cells from adult bone marrow, endowing them with the ability to mediate multilineage reconstitution that resembles fetal lymphopoiesis, including increased development of B-1a, marginal zone B, gamma/delta T cells, and natural killer T cells. [Science] Abstract Lethal Myelofibrosis Induced by Bmi1-Deficient Hematopoietic Cells Unveils a Tumor Suppressor Function of the Polycomb Group Genes Here, researchers show that loss of another polycomb-group gene, Bmi1, causes pathological hematopoiesis similar to primary myelofibrosis. [J Exp Med] Abstract The THPO/MPL/Bcl-xL Pathway Is Essential for Survival and Self-Renewal in Human Pre-Leukemia Induced by AML1-ETO In this report, investigators show that Bcl-xL is upregulated in AML1-ETO cells and plays an essential role in their survival and self-renewal. [Blood] Abstract FOXO1 Is a Tumor Suppressor in Classical Hodgkin Lymphoma Scientists found that in classical Hodgkin lymphoma cell lines FOXO1 is inactivated by multiple mechanisms, including constitutive activation of AKT/PKB and MAPK/ERK kinases and up-regulation of microRNAs miR-96, miR-182, and miR-183. [Blood] Abstract Depletion of RUNX1/ETO in t(8;21) AML Cells Leads to Genome-Wide Changes in Chromatin Structure and Transcription Factor Binding To obtain insights into RUNX1/ETO-dependant alterations of the epigenetic landscape, researchers measured genome-wide RUNX1- and RUNX1/ETO-bound regions in t(8;21) cells and assessed to what extent the effects of RUNX1/ETO on the epigenome depend on its continued expression in established leukemic cells. [Leukemia] Abstract Valproic Acid Induces Differentiation and Transient Tumor Regression, but Spares Leukemia-Initiating Activity in Mouse Models of APL Investigators have used several models of PML-RARA-driven acute promyelocytic leukemia (APL) to analyze the in vivo effects of valproic acid, a well-characterized histone deacetylase inhibitors. [Leukemia] Abstract Alpharetroviral Self-Inactivating Vectors: Long-Term Transgene Expression in Murine Hematopoietic Cells and Low Genotoxicity In a murine bone marrow transplantation model scientists compared alpharetroviral, gammaretroviral, and lentiviral self-inactivating vectors and showed that all vectors transduced hematopoietic stem cells, leading to comparable, sustained multilineage transgene expression in primary and secondary transplanted mice. [Mol Ther] Abstract Reactive Oxygen Species and Aldehyde Dehydrogenase Activity in Hodgkin Lymphoma Cells Findings show that aldehyde dehydrogenase-high and reactive oxygen species-low cells share cancer-initiating cell (CIC)-like potential, but they differ in their cell cycle status, suggesting that CICs are comprised of cells with heterogeneous characteristics. [Lab Invest] Abstract Tet2 Disruption Leads to Enhanced Self-Renewal and Altered Differentiation of Fetal Liver Hematopoietic Stem Cells Results demonstrate that ten-eleven translocation 2 (Tet2) plays a critical role in homeostasis of HSCs and hematopoietic progenitor cells not only in the bone marrow, but also in fetal liver. [Sci Rep] Abstract CLINICAL RESEARCH Risk Stratification-Directed Donor Lymphocyte Infusion Could Reduce Relapse of Standard-Risk Acute Leukemia Patients After Allogeneic Hematopoietic Stem Cell Transplantation Investigators prospectively studied the impact of risk stratification-directed interventions for minimal residual disease on relapse and disease-free survival in 814 persons with standard-risk acute leukemia receiving allotransplants in 1st or 2nd complete remission. [Blood] Abstract A Phase II Study of Rituximab-ABVD in Classical Hodgkin Lymphoma This multicenter phase II study investigated the combination of rituximab-ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) for stage II-IV untreated classical Hodgkin lymphoma. [Blood] Abstract Efficacy and Safety of Hematopoietic Stem Cell Remobilization with Plerixafor+G-CSF in Adult Patients with Germ Cell Tumors Herein, scientists describe a retrospective study examining safety and efficacy of plerixafor in combination with G-CSF for patients with germ cell tumors who had previously failed stem cell collection. [Bone Marrow Transplant] Abstract |