Hematopoiesis News Volume 3.08 | Feb 28 2012

Unique Dual Targeting of Thymidylate Synthase and Topoisomerase1 by FdUMP[10] Results in High Efficacy Against AML and Low Toxicity
The novel fluoropyrimidine, FdUMP[10] was better tolerated than 5-fluorouracil (5-FU) or cytarabine plus doxorubicin and did not affect normal hematopoietic stem cells while 5-FU dramatically impaired their ability to engraft. In summary, FdUMP[10] was highly efficacious and better tolerated than standard therapies. [Blood] Abstract

CD86 Is Expressed on Murine Hematopoietic Stem Cells and Denotes Lymphopoietic Potential
Researchers show that CD86^– CD150⁺ CD48^– hematopoietic stem cells from normal adult mice are particularly poor at restoring the adaptive immune system. [Blood] Abstract

p38αMAPK Interacts with and Inhibits RARα: Suppression of the Kinase Enhances the Therapeutic Activity of Retinoids in Acute Myeloid Leukemia Cells
Here, scientists provide evidence that pharmacological inhibition of the mitogen-activated protein-kinase, p38α, or silencing of the corresponding gene sensitizes acute promyelocytic leukemia and acute myelogenous leukemia (AML) cell lines, as well as primary cultures of AML blasts to the anti-proliferative and cyto-differentiating activity of all-trans retinoic acid and synthetic retinoids. [Leukemia] Abstract

Selective FLT3 Inhibition of FLT3-ITD⁺ Acute Myeloid Leukemia Resulting in Secondary D835Y Mutation: A Model for Emerging Clinical Resistance Patterns
Researchers generated selective FLT3 inhibitor-resistant cells by treating the FLT3-ITD⁺ human acute myeloid leukemia cell line MOLM-13 in vitro with the FLT3-selective inhibitor MLN518, and validated the resistant phenotype in vivo and in vitro. [Leukemia] Abstract

Jdp2 Downregulates Trp53 Transcription to Promote Leukemogenesis in the Context of Trp53 Heterozygosity
Scientists performed a genetic screen in mice to identify candidate genes that are associated with leukemogenesis in the context of Trp53 heterozygosity. [Oncogene] Abstract

Estradiol Increases Hematopoietic Stem and Progenitor Cells Independent on its Actions on Bone
Investigators demonstrate that estradiol action on stromal cells potently favors hematopoietic progenitor/stem cell frequency accompanied by enhanced expression of cell adhesion molecules. [Haematologica] Abstract

Pontin Is Essential for Murine Hematopoietic Stem Cell Survival
Researchers find that Pontin is highly expressed in embryonic stem cells and hematopoietic tissues. [Haematologica] Abstract

miR-196b Directly Targets Both HOXA9/MEIS1 Oncogenes and FAS Tumor Suppressor in MLL-Rearranged Leukemia
Here investigators show that HOXA9 and MEIS1 are direct targets of microRNA (miRNA)-196b, a miRNA located adjacent to and co-expressed with HOXA9, in MLL-rearranged leukemic cells. [Nat Commun] Abstract

CLINICAL RESEARCH

Phase II Study of Rituximab Plus ABVD in Patients with Newly Diagnosed Classical Hodgkin Lymphoma
Investigators evaluated the efficacy and safety of rituximab in combination with standard doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) in patients with classical Hodgkin lymphoma. [Blood] Abstract

Sorafenib Treatment of FLT3-ITD⁺ Acute Myeloid Leukemia: Favorable Initial Outcome and Mechanisms of Subsequent Non-Responsiveness Associated with a D835 Mutation
Thirteen relapsed or chemo-refractory fms-related tyrosine kinase-3- internal tandem duplication (FLT3-ITD⁺) acute myeloid leukemia  patients were treated with sorafenib (200-400 mg twice daily). [Blood] Abstract

Second Allogeneic Hematopoietic SCT for Relapsed ALL in Children
Scientists performed a retrospective analysis of 171 pediatric patients who received a second allo-SCT for relapsed ALL after allo-SCT. [Bone Marrow Transplant] Abstract

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the hematopoietic community

Scientist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist (STEMCELL Technologies Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies Inc.)

Business Analyst – Product Management (STEMSOFT Software Inc.)

Postdoctoral Fellow in Cytokine Signaling in Hematopoietic Stem Cells (University of Pennsylvania School of Medicine)

Postdoctoral Fellow in Stem Cells and Cancer (Tsinghua University)

Postdoctoral/Research Associate (Children’s Memorial Research Center)

Pediatric Faculty – Hematology/Oncology Stem Cell Sciences (The University of Chicago)

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