LABORATORY RESEARCH Salidroside Stimulates DNA Repair Enzyme Parp-1 Activity in Mouse HSC Maintenance Researchers show that Salidroside prevented the loss of hematopoietic stem cells (HSCs) in mice under oxidative stress. [Blood] Abstract An Insertional Mutagenesis Screen Identifies Genes That Cooperate with Mll-AF9 in a Murine Leukemogenesis Model Data identified genes that define transcription factor networks and important genetic pathways acting during progression of leukemia induced by MLL fusion oncogenes. [Blood] Abstract Norepinephrine Reuptake Inhibition Promotes Mobilization in Mice: Potential Impact to Rescue Low Stem Cell Yields The mechanisms mediating hematopoietic stem and progenitor cell mobilization by G-CSF are complex. Researchers show that G-CSF likely alters sympathetic tone directly and that methods to increase adrenergic activity in the bone marrow microenvironment enhance progenitor mobilization. [Blood] Abstract Concomitant Inactivation of Rb and E2f8 in Hematopoietic Stem Cells Synergizes to Induce Severe Anemia In an effort to understand whether Rb function can be mediated by E2F transcription factors in a bone marrow-derived hematopoietic system in mice, investigators uncovered a functional synergy between Rb and E2F8 to promote erythropoiesis and to prevent anemia. [Blood] Abstract Myeloid Leukemia Factor Is a Conserved Regulator of RUNX Transcription Factor Activity Involved in Hematopoiesis Scientists report that myeloid leukemia factor mlf controls the homeostasis of the Drosophila hematopoietic system. [Proc Natl Acad Sci USA] Abstract A Model for Personalized In Vivo Analysis of Human Immune Responsiveness Researchers demonstrated robust immune reconstitution in mice with hematopoietic stem cells aspirated from bone marrow of adults with type 1 diabetes and healthy control volunteers. [Sci Transl Med] Abstract | Press Release CLINICAL RESEARCH Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia Investigators performed a mutational analysis of 18 genes in 398 patients younger than 60 years of age who had acute myeloid leukemia and who were randomly assigned to receive induction therapy with high-dose or standard-dose daunorubicin. [New Engl J Med] Abstract | Press Release Clonal Architecture of Secondary Acute Myeloid Leukemia Scientists performed whole-genome sequencing of seven paired samples of skin and bone marrow in seven subjects with secondary acute myeloid leukemia (AML) to identify somatic mutations specific to secondary AML. [New Engl J Med] Abstract | Press Release Phase II Study of the JAK Kinase Inhibitor Ruxolitinib in Patients with Refractory Leukemias, Including Post Myeloproliferative Neoplasms (MPN) Acute Myeloid Leukemia (AML) Scientists conducted a phase II study of ruxolitinib in patients with relapsed/refractory leukemias. [Blood] Abstract Favorable Effect of Priming with Granulocyte Colony-Stimulating Factor in Remission Induction of Acute Myeloid Leukemia Restricted to Dose-Escalation of Cytarabine Researchers randomized 917 acute myeloid leukemia patients to receive granulocyte colony-stimulating factor (G-CSF) (456 patients) or no G-CSF (461 patients) at the days of chemotherapy. [Blood] Abstract |