Hematopoiesis News Volume 3.12 | Mar 27 2012

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Scientists found that the transcription factor Myb was required for development of hematopoietic stem cells and all CD11b^high monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of YS-derived F4/80^bright macrophages in several tissues. [Science] Abstract

Commensal Bacteria-Derived Signals Regulate Basophil Hematopoiesis and Allergic Inflammation
Results identify a previously unrecognized pathway through which commensal-derived signals influence basophil hematopoiesis and susceptibility to T_H2 cytokine–dependent inflammation and allergic disease. [Nat Med] Abstract

Cell Transformation by FLT3 ITD in Acute Myeloid Leukemia Involves Oxidative Inactivation of the Tumor Suppressor Protein-Tyrosine Phosphatase DEP-1/PTPRJ
The present study addressed the role of DEP-1 for regulation of the AML-related mutant FMS-like tyrosine kinase 3 (FLT3) ITD protein. [Blood] Abstract

Dynamic HoxB4 Regulatory Network During Embryonic Stem Cell Differentiation to Hematopoietic Cells
Scientists performed global gene expression profiling and chromatin immunoprecipitation coupled with deep sequencing at four stages of the HoxB4-mediated embryonic stem cell differentiation towards hematopoietic cells. [Blood] Abstract

Cotargeting Signaling Pathways Driving Survival and Cell Cycle Circumvents Resistance to Kit Inhibitors in Leukemia
To elucidate the biochemical networks connecting Kit mutant to leukemogenesis, researchers performed a global profiling of tyrosine-phosphorylated proteins from mutant Kit-driven murine leukemia pro-erythroblasts. [Blood] Abstract

Inhibition of Bcl-2 Anti-Apoptotic Members by Obatoclax Potently Enhances Sorafenib-Induced Apoptosis in Human Myeloid Leukemia Cells through a Bim-Dependent Process
Interactions between the multi-kinase inhibitor sorafenib and the BH3-mimetic obatoclax were examined in human myeloid leukemia cells. [Blood] Abstract

The miR-17-92 Cluster Expands Multipotent Hematopoietic Progenitors while Imbalanced Expression of its Individual Oncogenic miRNAs Promotes Leukemia in Mice
The present study demonstrates that retroviral-mediated miR-17-92 overexpression promotes expansion of multipotent hematopoietic progenitors in mice. [Blood] Abstract

Co-Transplantation of Pure Blood Stem Cells with Antigen-Specific But Not Bulk T Cells Augments Functional Immunity
Scientists studied reactivity against the mouse homolog, murine CMV, in lethally irradiated mice given allogeneic purified hematopoietic stem cells (HSCs) or HSCs supplemented with T cells or T-cell subsets. [Proc Natl Acad Sci USA] Abstract

Distinct B-Cell Lineage Commitment Distinguishes Adult Bone Marrow Hematopoietic Stem Cells
Studies here finally demonstrate that individual hematopoietic stem cells (HSCs) sorted from adult bone marrow and transferred to lethally irradiated recipients clearly give rise to B-2, MZ B, and B-1b, but do not detectably reconstitute B-1a cells. [Proc Natl Acad Sci USA] Abstract

Mast Cells Promote the Growth of Hodgkin’s Lymphoma Cell Tumor by Modifying the Tumor Microenvironment that Can Be Perturbed by Bortezomib
Researchers report that mast cells promote the growth of Hodgkin’s tumor by modifying the tumor microenvironment. [Leukemia] Abstract

CLINICAL RESEARCH

Cyclin-Dependent Kinase 7/9 Inhibitor SNS-032 Abrogates FIP1-Like-1-Platelet-Derived Growth Factor Receptor α and Bcr-Abl Oncogene Addiction in Malignant Hematologic Cells
The purpose of this study was to evaluate the strategy of shutting down the transcription and expression of FIP1-like-1-platelet-derived growth factor receptor α and Bcr-Abl with SNS-032, an inhibitor of cyclin-dependent kinase 7 (CDK7) and CDK9 in phase I clinical trials. [Clin Cancer Res] Abstract

Evaluation of Allogeneic Hematopoietic SCT in Younger Adults with Adverse Karyotype AML
To illustrate methodological issues, researchers compared donor vs no-donor to transplant vs no-transplant comparisons in a cohort of 107 patients aged 50 years with adverse karyotype AML in first CR. [Bone Marrow Transplant] Abstract

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Engineering Conferences International – Cell Culture Engineering XIII
April 22-27, 2012
Scottsdale, United States

Visit our events page to see a complete list of events in the hematopoietic community

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies Inc.)

Scientist – Hematology (STEMCELL Technologies Inc.)

Scientist – hPSC (STEMCELL Technologies Inc.)

Business Analyst – Product Management (STEMSOFT Software Inc.)

Principal Investigators in Cancer Research (Institut de Recherches Cliniques de Montéal)

Postdoctoral Fellow in Stem Cells and Cancer (Tsinghua University)

Postdoctoral Fellow in Cytokine Signaling in Hematopoietic Stem Cells (University of Pennsylvania School of Medicine)

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