Hematopoiesis News Volume 3.16 | Apr 24 2012

LABORATORY RESEARCH

Thrombin Receptor Regulates Hematopoiesis and Endothelial-to-Hematopoietic Transition
Investigators showed that thrombin receptor, a protease-activated G protein-coupled receptor required for vascular development, functions as a negative regulator during hematopoietic development. [Dev Cell] Abstract

Cell-Nonautonomous Hedgehog Signaling Promotes Murine B Lymphopoiesis from Hematopoietic Progenitors
Results suggest that activity of the hedgehog pathway within stromal cells promotes B lymphopoiesis in a cell-nonautonomous fashion. [Blood] Abstract

Osteopontin Is a Prognostic Factor for Survival of Acute Myeloid Leukemia Patients
Investigators analyzed the prognostic impact of osteopontin in acute myeloid leukemia. [Blood] Abstract

Bid Protects the Mouse Hematopoietic System following Hydroxyurea-Induced Replicative Stress
Scientists investigated the role of the BH3-only Bcl-2 family member Bid in the response of murine hematopoietic cells to long-term replicative stress induced by hydroxyurea. [Cell Death Differ] Abstract

Direct Toll Like Receptor-Mediated Stimulation of Hematopoietic Stem and Progenitor Cells Occurs In Vivo and Promotes Differentiation Towards Macrophages
Results show that hematopoietic stem and progenitor cells may be directly stimulated by Toll like receptor agonists in vivo, and that the engagement of these receptors induces differentiation towards macrophages. [Stem Cells] Abstract

Role of Misfolded N-CoR Mediated Transcriptional Deregulation of Flt3 in Acute Monocytic Leukemia (AML)-M5 Subtype
Researchers report that loss of nuclear receptor co-repressor (N-CoR)-mediated transcriptional control of Flt3 due to misfolding contributes to malignant growth in AML of the M5 subtype. [PLoS One] Abstract

Allogeneic Bone Marrow Grafts with High Levels of CD4⁺CD25⁺FoxP3⁺ T Cells Can Lead to Engraftment Failure
Researchers showed that co-transplantation of bone marrow cells with high levels of regulatory CD4⁺CD25⁺FoxP3⁺ T cells leads to a 100% survival of mice and significantly accelerates the hematopoietic recovery. [Cytometry A] Abstract

CLINICAL RESEARCH

Cladribine, but Not Fludarabine, Added to Daunorubicin and Cytarabine during Induction Prolongs Survival of Patients with Acute Myeloid Leukemia: A Multicenter, Randomized Phase III Study
Researchers evaluated whether the addition of a purine analog, cladribine or fludarabine, to the standard induction regimen affects the outcome of adult patients with acute myeloid leukemia. [J Clin Oncol] Abstract

Ultra-Short Course Sirolimus Contributes to Effective GvHD Prophylaxis after Reduced-Intensity Allogeneic Hematopoietic Cell Transplantation
A totaly of 37 patients underwent reduced-intensity conditioning allo-SCT after induction treatment with EPOCH-F(R) using a novel form of dual-agent immunosuppression for GvHD prophylaxis with CsA and sirolimus. [Bone Marrow Transplant] Abstract

Inform Genomics Announces Results of Study Predicting Risk of Oral Mucositis in Patients Undergoing High Dose Chemotherapy
Inform Genomics, Inc. announced the completion of the first phase of product development to predict a patient’s risk of developing oral mucositis after receiving high dose chemotherapy prior to hematopoietic stem cell transplant. [Inform Genomics, Inc.] Press Release

AMAG Pharmaceuticals Announced a Positive CHMP Opinion for the Approval of Ferumoxytol in Europe for the Treatment of Iron Deficiency Anemia in Adult Patients with Chronic Kidney Disease
AMAG Pharmaceuticals, Inc. announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has issued a positive opinion for the approval of ferumoxytol, an intravenous iron therapy, for the treatment of iron deficiency anemia in adult patients with chronic kidney disease. [BusinessWire] Press Release

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies Inc.)

Scientist – hPSC (STEMCELL Technologies Inc.)

Business Analyst – Product Management (STEMSOFT Software Inc.)

Principal Investigators in Cancer Research (Institut de Recherches Cliniques de Montréal)

Postdoctoral Fellow in Stem Cells and Cancer (Tsinghua University)

Postdoctoral Fellow – Hematopoietic Stem Cells and Leukemia (City of Hope Beckman Research Institute)

Postdoctoral Position – Hematopoietic Stem Cell Research (University of Texas Southwestern)

Postdoctoral Fellow – Stem Cell Research (University of Texas Health Science Center)

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