Hematopoiesis News Volume 3.17 | May 1 2012

LABORATORY RESEARCH

A Critical Role for Endoglin in the Emergence of Blood during Embryonic Development
Scientists showed that endoglin identifies all cells with hematopoietic fate in the early embryo. [Blood] Abstract

CD1d Expression on and Regulation of Murine Hematopoietic Stem and Progenitor Cells
Surface CD1d, involved in immune cell interactions, was assessed for effects on hematopoiesis. [Blood] Abstract

Enhancement of Hematopoiesis and Lymphopoiesis in Diet-Induced Obese Mice
A rodent model of diet-induced obesity revealed that obesity significantly altered hematopoietic and lymphopoietic functions in the bone marrow and thymus. [Proc Natl Acad Sci USA] Abstract

Expansion of Bone Marrow Neutrophils following G-CSF Administration in Mice Results in Osteolineage Cell Apoptosis and Mobilization of Hematopoietic Stem and Progenitor Cells
Researchers showed that granulocyte-colony stimulating factor (G-CSF) driven neutrophil expansion alters the bone marrow niche that leads to hematopoietic stem/progenitor cells mobilization. [Leukemia] Abstract

Hematopoietic Stem Cell and Gene Therapy Corrects Primary Neuropathology and Behavior in Mucopolysaccharidosis IIIA Mice
Scientists compared hematopoietic stem cell transplantation in mucopolysaccharidosis IIIA (MPS IIIA) mice using wild-type donor cells transduced ex vivo with lentiviral vector-expressing lysosomal enzyme sulfamidase (SGSH) versus wild-type donor cell transplant or lentiviral-SGSH transduced MPS IIIA cells. [Mol Ther] Abstract

Hematopoietic Precursor Cells Isolated from Patients on Long Term Suppressive HIV Therapy Did Not Contain HIV-1 DNA
Scientists addressed the key emerging question of whether Lin^–/CD34⁺ hematopoietic precursor cells represent an important latent reservoir of HIV-1 during long-term suppressive therapy. [J Infect Dis] Abstract

Preliminary Evidence for the Dedifferentiation of RAW 264 Cells into Mesenchymal Progenitor-Like Cells by a Purine Analog
Researchers purpose was to de- and re-differentiate murine RAW 264.7 cells, a committed macrophage cell line of hematopoietic origin, into mesenchymal-like cells such as osteoblasts. [Tissue Eng Part A] Abstract

Development of B Cells and Erythrocytes Is Specifically Impaired by the Drug Celastrol in Mice
Researchers investigated the effects of celastrol on the adult murine hematopoietic system. [PLoS One] Abstract

CLINICAL RESEARCH

Infusion of Hemolyzed Red Blood Cells within Peripheral Blood Stem Cell Grafts in Patients with and without Sickle Cell Disease
Researchers evaluated whether the infusion of peripheral blood stem cell grafts containing lysed red blood cells leads to the toxicity observed in transplant subjects. [Blood] Abstract

Evaluation of BM Cytomorphology after Allo-SCT in Patients with AML
Scientists studied cellularity and dysplasia in BM cytomorphology on days 30 and 100 in 112 AML patients who achieved hematological CR after SCT. [Bone Marrow Transplant] Abstract

Phase I Study of the Tolerability and Pharmacokinetics of Palifermin in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
This phase I study of palifermin was designed to evaluate its tolerability at doses of 40, 60 and 90 μg/kg/day, in children two to 18 years of age, receiving a myeloablative preparative regimen for allogeneic hematopoietic stem cell transplantation. [Biol Blood Marrow Transplant] Abstract

ASH Agenda for Hematology Research Identifies Most Promising Areas for Scientific Discovery
The American Society of Hematology (ASH) issued a report urging federal agencies to coordinate hematology research funding around seven specific high-need areas that would produce the greatest impact and translate into improvements in patient care in the United States. [American Society of Hematology]
Press Release

QBC Diagnostics Awarded GSA Contract
QBC Diagnostics announced that the company has been awarded a U.S. General Services Administration (GSA) Schedule 66 Contract for Scientific Equipment and Services. GSA’s Scientific Equipment and Services Schedule 66 Contract provides federal agencies with scientific instruments for a wide variety of uses such as public safety, medical research, and laboratory diagnostics. [QBC Diagnostics, Inc.]
Press Release

Onyx Pharmaceuticals Announces FDA Advisory Committee to Review Carfilzomib for the Treatment of Patients with Relapsed and Refractory Multiple Myeloma
Onyx Pharmaceuticals, Inc. announced that the U.S. Food and Drug Administration’s (FDA) Oncologic Drugs Advisory Committee will review the company’s new drug application for carfilzomib for the treatment of patients with relapsed and refractory multiple myeloma who have received at least two prior therapies. [Onyx Pharmaceuticals, Inc.] Press Release

Chinese Publishers Vow to Cleanse Journals
The China Association for Science and Technology in Beijing has taken the lead among the country’s publishers in trying to clamp down on academic misconduct. [The China Association for Science and Technology, China] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies Inc.)

Business Analyst – Product Management (STEMSOFT Software Inc.)

Principal Investigators in Cancer Research (Institut de Recherches Cliniques de Montréal)

Postdoctoral Fellow in Stem Cells and Cancer (Tsinghua University)

Postdoctoral Fellow – Hematopoietic Stem Cells and Leukemia (City of Hope Beckman Research Institute)

Postdoctoral Position – Hematopoietic Stem Cell Research (University of Texas Southwestern)

Postdoctoral Fellow – Stem Cell Research (University of Texas Health Science Center)

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