Hematopoiesis News Volume 3.21 | May 29 2012

LABORATORY RESEARCH

mTORC1 Is Essential for Leukemia Propagation but Not Stem Cell Self-Renewal
Reseachers investigated the role of mTOR complex 1 (mTORC1) in mouse hematopoiesis using a mouse model of conditional deletion of Raptor, an essential component of mTORC1. [J Clin Invest] Full Article

APELIN Promotes Hematopoiesis from Human Embryonic Stem Cells
Investigators identified APELIN as a novel growth factor for human embryonic stem cell derived hematopoietic and endothelial cells. [Blood] Abstract

Connexin-43 Prevents Hematopoietic Stem Cell Senescence through Transfer of Reactive Oxygen Species to Bone Marrow Stromal Cells
Results indicated that connexin-43 exerts a protective role and regulates the hematopoietic stem cell and progenitor cell reactive oxygen species (ROS) content through ROS transfer to the hematopoietic microenvironment, resulting in HSC protection during stress hematopoietic regeneration. [Proc Natl Acad Sci USA] Abstract

Signaling Profiling at the Single-Cell Level Identifies a Distinct Signaling Signature in Murine Hematopoietic Stem Cells
Researchers studied signaling evoked from three representative cytokines, stem cell factor and thrombopoietin that are essential for hematopoietic stem cell (HSC) function, and granulocyte macrophage-colony stimulating factor that is dispensable for HSCs. [Stem Cells] Abstract

Etv2 Is Expressed in the Yolk Sac Hematopoietic and Endothelial Progenitors and Regulates Lmo2 Gene Expression
Investigators defined the role of Ets variant 2 (Etv2) in yolk sac blood island development using a Etv2 mutant and a novel Etv2–EYFP reporter transgenic line. [Stem Cells] Abstract

Development of Mature and Functional Human Myeloid Subsets in Hematopoietic Stem Cell-Engrafted NOD/SCID/IL2rγKO Mice
Scientists investigated in vivo differentiation and function of human myeloid subsets in NOD/SCID/IL2rγ^null mouse recipients transplanted with purified lineage-CD34⁺CD38^– cord blood hematopoietic stem cells. [J Immunol] Abstract

Erythroid Promoter Confines FGF2 Expression to the Marrow after Hematopoietic Stem Cell Gene Therapy and Leads to Enhanced Endosteal Bone Formation
Researchers report that the use of an erythroid specific promoter leads to a five-fold decrease in the ratio of serum fibroblast growth factor-2 (FGF2) to the FGF2 expression in the marrow cavity when compared to the use of a ubiquitous promoter spleen focus-forming virus. [PLoS One] Full Article

Compositional Dependence of Hematopoietic Stem Cells Expansion on Bioceramic Composite Scaffolds for Bone Tissue Engineering
The authors report the expansion of hematopoietic stem cells on as-synthesized composite scaffolds from hydroxyapatite and β-tricalcium phosphate for bone tissue engineering. [J Biomed Mater Res A] Abstract

CLINICAL RESEARCH

Exercise Increases the Frequency of Circulating Hematopoietic Progenitor Cells but Reduces Hematopoietic Colony Forming Capacity
Scientists aimed to investigate the influence of physical exercise and normobaric hypoxia on circulating hematopoietic progenitor cells number and functionality in the peripheral blood as well as the involvement of oxidative stress parameters as possibly active agents. [Stem Cells Dev] Abstract

Phase II Study of Dose-Modified Busulfan by Real-Time Targeting in Allogeneic Transplantation for Myeloid Malignancy
Scientists evaluated the efficacy and safety of allogeneic hematopoietic stem cell transplantation with targeted oral busulfan and cyclophosphamide in a phase II study. [Cancer Sci] Abstract

Maryland Stem Cell Research Commission Funds 40 New Proposals in FY 2012
The board of directors of the Maryland Technology Development Corporation approved the Commission’s recommendation to fund 40 new proposals with the Maryland Stem Cell Research Fund’s $12.4 million FY 2012 budget. [Maryland Stem Cell Research Fund] Press Release

ThermoGenesis Announces AXP Approval in Thailand
ThermoGenesis Corp. said that it received regulatory approval in Thailand for its AXP^® AutoXpress^® Platform (AXP) used for the processing of cord blood. [ThermoGenesis Corp.] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Keystone Symposia on Molecular and Cellular Biology – Myeloid Cells: Regulation and Inflammation
February 19-24, 2013
Keystone, United States

NEW Gordon Research Conference: Cell Biology of Megakaryocytes and Platelets
March 10-15, 2013
Galveston, United States
  
Visit our events page to see a complete list of events in the hematopoietic community.

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software Inc.)

Postdoctoral Position – Hematopoietic Stem Cells and Leukemia (City of Hope National Medical Center)

Postdoctoral Position – Hematopoietic Stem Cell Research (University of Texas Southwestern Medical Center)

Postdoctoral Fellowship – Cellular Origin of Blood Cells (European Molecular Biology Laboratory)

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