| PUBLICATIONS (Ranked by impact factor of the journal) | LABORATORY RESEARCH Exome Sequencing Identifies GATA1 Mutations Resulting in Diamond-Blackfan Anemia These findings provide insight into the pathogenesis of Diamond-Blackfan anemia, showing that the reduction in erythropoiesis associated with the disease can arise from causes other than defects in ribosomal protein genes. These results also illustrate the multifactorial role of GATA1 in human hematopoiesis. [J Clin Invest] Full Article Genome-Wide DNA Methylation Profiles in Hematopoietic Stem and Progenitor Cells Reveal Over-Representation of ETS Transcription Factor Binding Sites To better understand the role of DNA methylation in hematopoiesis, we characterized genome-wide DNA methylation in primary mouse hematopoietic stem cells, common myeloid progenitors, and erythroblasts. [Genome Res] Abstract Stable Long-Term Blood Formation by Stem Cells in Murine Steady-State Hematopoiesis This study represents the first continuous analysis of clonal behavior of genetically marked hematopoietic cells in an unmanipulated system, providing evidence that multiple clones are simultaneously active in murine steady-state hematopoiesis. [Stem Cells] Abstract MYC Antagonizes the Differentiation Induced by Imatinib in Chronic Myeloid Leukemia Cells through Downregulation of p27KIP1 The results suggest that, although MYC deregulation does not directly confer resistance to imatinib, it might be a factor that contributes to progression of chronic myeloid leukemia through the inhibition of differentiation. [Oncogene] Abstract Distinctive Contact between CD34+ Hematopoietic Progenitors and CXCL12+ CD271+ Mesenchymal Stromal Cells in Benign and Myelodysplastic Bone Marrow Scientists analyzed putative mesenchymal stromal cell markers and their relationship to CD34+ hematopoietic stem/progenitor cells within intact human bone marrow in paraffin-embedded bone marrow core biopsies of benign, myelodysplastic syndrome and leukemic marrows using tissue microarrays to facilitate scanning, image analysis and quantitation. [Lab Invest] Abstract Adenosine Receptor A2b on Hematopoietic Cells Mediates LPS-Induced Migration of Polymorphonuclear Leukocytes into the Lung Interstitium The results demonstrate anti-inflammatory effects of A2b on two major characteristics of acute lung injury, with a distinct role of hematopoietic A2b for cell trafficking and endothelial A2b for microvascular permeability. [Am J Physiol Lung Cell Mol Physiol] Abstract Inhibition of Erythropoiesis by Smad6 in Human Cord Blood Hematopoietic Stem Cells Researchers suggest that Smad6 indirectly maintains stemness by preventing spontaneous erythropoiesis in hematopoietic stem cells. [Biochem Biophys Res Commun] Abstract CLINICAL RESEARCH All-Trans-Retinoic Acid, Idarubicin, and Intravenous Arsenic Trioxide as Initial Therapy in Acute Promyelocytic Leukemia The treatment of acute promyelocytic leukemia has improved considerably following recognition of the effectiveness of all-trans-retinoic acid, anthracycline-based chemotherapy, and arsenic trioxide. Researchers report the use of all three agents in combination. [Blood] Abstract Allogeneic Hematopoietic Stem Cell Transplantation for Adult AML Patients with Granulocytic Sarcoma Investigators assessed the efficacy of allogeneic hematopoietic stem cell transplantation for the management of acute myeloid leukemia (AML) with granulocytic sarcoma. [Leukemia] Abstract Elacytarabine Has Single-Agent Activity in Patients with Advanced Acute Myeloid Leukemia This Phase II study assessed the efficacy and safety of elacytarabine in patients with advanced stage acute myeloid leukemia. [Br J Haematol] Abstract |
| JOB OPPORTUNITIES | Research Associate – Chemistry (STEMCELL Technologies, Inc.) Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.) Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.) Research Technologist – Media Development (STEMCELL Technologies, Inc.) Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.) Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.) Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.) Postdoctoral Fellowship – Cellular Origin of Blood Cells (European Molecular Biology Laboratory) PhD Position – Construction of a Biomimetic, Hematopoietic Stem Cell Niche (Karlsruhe Institute of Technology – Helmholtz Association) Postdoctoral Position – Hematopoietic Stem Cell Biology and Immunology (University of California, San Francisco) Postdoctoral Position – Hematopoietic Lineage Commitment and Leukemia Development (University of Oxford – Weatherall Institute of Molecular Medicine) Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost. |
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