LABORATORY RESEARCH Scl Represses Cardiomyogenesis in Prospective Hemogenic Endothelium and Endocardium Researchers showed that the transcription factor Scl/Tal1 is essential for both establishing the hematopoietic transcriptional program in the hemogenic endothelium and preventing its misspecification to a cardiomyogenic fate. [Cell] Abstract | Press Release Targeting Tetramer-Forming GABPβ Isoforms Impairs Self-Renewal of Hematopoietic and Leukemic Stem Cells Scientists demonstrated that GABPβ1L/β2 deficiency specifically impairs hematopoietic stem cell (HSC) quiescence and survival, with little impact on cell cycle or apoptosis in differentiated blood cells. They also showed targeting GABPβ1L/β2 also impairs leukemia stem cell self-renewal in p210BCR-ABL-induced chronic myelogenous leukemia (CML) and exhibits synergistic effects with tyrosine kinase inhibitor imatinib therapy in inhibiting CML propagation. [Cell Stem Cell] Abstract Activated Gs Signaling in Osteoblastic Cells Alters the Hematopoietic Stem Cell Niche in Mice Researchers suggest that long-term activation of Gs signaling in osteoblastic lineage cells leads to contextual changes in the bone marrow niche that adversely affect hematopoietic stem cell maintenance and blood homeostasis. [Blood] Abstract Dicer Is Selectively Important for the Earliest Stages of Erythroid Development By using Dicer inactivation, researchers showed that the microRNA complex is not only essential for hematopoietic stem cell maintenance, but is specifically required for their erythroid programming and subsequent generation of committed erythroid progenitors. [Blood] Abstract miR-433 Is Aberrantly Expressed in Myeloproliferative Neoplasms and Suppresses Hematopoietic Cell Growth and Differentiation Despite its upregulation in myeloproliferative neoplasms CD34+ and during normal erythropoiesis, both overexpression and knockdown studies suggest that miR-433 negatively regulates CD34+ proliferation and differentiation ex vivo. Its novel target GBP2 is downregulated during normal erythropoiesis and regulates proliferation and erythroid differentiation in TF-1 cells, indicating that miR-433 negatively regulates hematopoietic cell proliferation and erythropoiesis by directly targeting GBP2. [Leukemia] Abstract Anti-Leukemic Activity of Nuclear Export Inhibitors that Spare Normal Hematopoietic Cells Scientists report on the structural analysis and anti-leukemic activity of a new generation of small-molecule inhibitors of chromosome region maintenance 1 protein. [Leukemia] Abstract High-efficiency Transduction of Rhesus Hematopoietic Repopulating Cells by a Modified HIV1-based Lentiviral Vector To evaluate whether chimeric human immunodeficiency virus type 1 (χHIV) vectors could efficiently transduce rhesus hematopoietic repopulating cells, researchers performed a competitive repopulation assay in rhesus macaques, in which half of the CD34+ cells were transduced with standard simian immunodeficiency virus vectors and the other half with χHIV vectors. [Mol Ther] Abstract Chemoselection of Allogeneic HSC after Murine Neonatal Transplantation Without Myeloablation or Post-Transplant Immunosuppression The feasibility of allogeneic transplantation, without myeloablation or post-transplant immunosuppression, was tested using in vivo chemoselection of allogeneic hematopoietic stem cells (HSCs) after transduction with a novel tricistronic lentiviral vector. [Mol Ther] Abstract BMK1 Is Involved in the Regulation of p53 through Disrupting the PML-MDM2 Interaction Results not only suggest that big MAP kinase 1 (BMK1) activity has a role in suppressing p53 by blocking the interaction between promyelocytic leukemia protein (PML) and MDM2, but also implicate that pharmacological BMK1 inhibitor should significantly enhance the anticancer capacity of doxorubicin-based chemotherapy. [Oncogene] Abstract CLINICAL RESEARCH Reversible Skeletal Disease and High Fluoride Serum Levels in Hematologic Patients Receiving Voriconazole Investigators found that serum fluoride levels were elevated on average five-fold above normal levels in hematological patients receiving voriconazole. Clinically relevant skeletal disease was associated with renal insufficiency and above ten-fold elevated fluoride levels, and was reversible upon termination of voriconazole treatment. [Blood] Abstract Phase I Study of the Aurora B Kinase Inhibitor Barasertib to Assess the Pharmacokinetics, Metabolism and Excretion in Patients with Acute Myeloid Leukemia The pharmacokinetic, metabolic and excretion profiles of barasertib and barasertib-hQPA were characterized in this open-label Phase I study. [Cancer Chemother Pharmacol] Abstract |