Hematopoiesis News Volume 3.35 | Sep 4 2012

LABORATORY RESEARCH

Cyclin D3 Coordinates the Cell Cycle during Differentiation to Regulate Erythrocyte Size and Number
By examining human and mouse primary erythroid cells, researchers demonstrated that the CCND3 gene product cyclin D3 regulates the number of cell divisions that erythroid precursors undergo during terminal differentiation, thereby controlling erythrocyte size and number. [Genes Dev] Abstract | Press Release

Adaptor Protein Lnk Binds to and Inhibits Normal and Leukemic FLT3
Researchers showed that through direct binding to FLT3, Lnk suppresses wild-type FLT3/internal tandem duplications-dependent signaling pathways involved in the proliferation of hematopoietic cells. [Blood] Abstract

Conditional TRF1 Knockout in the Hematopoietic Compartment Leads to Bone Marrow Failure and Recapitulates Clinical Features of Dyskeratosis Congenita
To address a possible role for TRF1 dysfunction in bone marrow failure, researchers generated a mouse model with conditional TRF1 deletion in the hematopoietic system. [Blood] Abstract | Press Release

Hematopoietic Overexpression of the Transcription Factor Erg Induces Lymphoid and Erythro-Megakaryocytic Leukemia
Investigators suggested that E-twenty-six-related gene (Erg) overexpression induces the development of not only lymphoid leukemia but also erythro-megakaryocytic leukemia. [Proc Natl Acad Sci USA] Abstract

Clonal Evolution of Preleukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia
Investigators proposed that serial acquisition of mutations occurs in self-renewing hematopoietic stem cells (HSCs). They investigated this model through genomic analysis of HSCs from six patients with de novo acute myeloid leukemia. [Sci Transl Med] Abstract | Press Release

Human Responses against HER-2-Positive Cancer Cells in Human Immune System-Engrafted Mice
Researchers used human immune system mice to study human immune responses against human HER-2-positive cancer cells and their ability to control tumor growth and metastasis. BALB/c Rag2^-/-, Il2rg^-/- mice were engrafted with CD34⁺ or CD133⁺ human cord blood hematopoietic stem cells and vaccinated with human HER-2-positive cancer cells SK-OV-3 combined to human IL-12. [Br J Cancer] Full Article

The Multi-Kinase Inhibitor TG02 Overcomes Signaling Activation by Survival Factors to Deplete MCL1 and XIAP and Induce Cell Death in Primary Acute Myeloid Leukemia Cells
Scientists evaluated the in vitro toxicity of TG02 to primary acute myeloid leukemia cells in the presence of survival signaling pathway activation by cytokines and fibronectin. [Br J Haematol] Abstract

The Peptide Derived from the Ig-Like Domain of Human Herpes Virus 8 K1 Protein Induces Death in Hematopoietic Cancer Cells
Researchers showed that the S20-3 peptide can selectively induce the death of malignant hematological cell lines in Fas- and/or TNFRI-dependent mechanisms, suggesting the K1-derived peptide or peptidomimetic may have promising therapeutic potential for the treatment of hematological cancers. [J Exp Clin Cancer Res] Abstract | Full Article

CLINICAL RESEARCH

HLA-C-Dependent Prevention of Leukemia Relapse by Donor Activating KIR2DS1
Researchers assessed clinical data, HLA genotyping results, and donor cell lines or genomic DNA for 1277 patients with acute myeloid leukemia who had received hematopoietic stem-cell transplants from unrelated donors matched for HLA-A, B, C, DR, and DQ or with a single mismatch. [N Engl J Med] Abstract

Long-Term Efficacy and Safety of Arsenic Trioxide for First-Line Treatment of Elderly Patients with Newly Diagnosed Acute Promyelocytic Leukemia
A total of 33 patients aged 60 years or older with de novo acute promyelocytic leukemia were treated with single-agent arsenic trioxide for remission induction and post remission therapy. The post remission therapy continued for up to four years. [Cancer] Abstract

Foundation Supports Childhood Cancer Research at Baylor College of Medicine
Three childhood cancer researchers at Baylor College of Medicine and Texas Children’s Cancer Center have received almost $700,000 in support from the St. Baldrick’s Foundation. Their awards were part of more than $22.5 million in new grants to support the best in pediatric oncology research in the United States. [Baylor College of Medicine] Press Release

Leukemia & Lymphoma Society Awards $1.8 Million to Weill Cornell for Translational Research in Blood Cancers
Weill Cornell Medical College has been awarded three new research grants from the Leukemia & Lymphoma Society totaling $1.8 million. The funds will support critically-needed translational research for blood cancers, accelerating promising discoveries from the laboratory to the patient’s bedside. [Weill Cornell Medical College] Press Release

Goodell Named ASH’s 2012 William Dameshek Prize Award Winner
Dr. Margaret Goodell, director of the Stem Cells and Regenerative Medicine Center at Baylor College of Medicine, has been named the American Society of Hematology’s (ASH’s) 2012 William Dameshek Prize winner, an annual honor that recognizes an investigator who has made outstanding contributions to hematology research. [Baylor College of Medicine] Press Release

The American Society of Hematology Honors James N. George, MD, with 2012 Wallace H. Coulter Award for Lifetime Achievement in Hematology
The American Society of Hematology (ASH) will present the 2012 Wallace H. Coulter Award for Lifetime Achievement in Hematology, the Society’s highest honor, to James N. George, MD, of the University of Oklahoma Health Sciences Center for his distinguished, 50-year career combining outstanding basic and clinical research investigation, extraordinary teaching and mentorship, and exceptional patient care. [American Society of Hematology] Press Release

The American Society of Hematology Honors David Ginsburg, MD, and Richard Aster, MD, with 2012 Henry M. Stratton Medal
The American Society of Hematology (ASH) announced that it will recognize David Ginsburg, MD, of the University of Michigan in Ann Arbor and Howard Hughes Medical Institute, and Richard H. Aster, MD, of the Blood Center of Wisconsin and Medical College of Wisconsin, with the 2012 Henry M. Stratton Medal for their accomplishments in the fields of thrombosis and blood cell immunology. [American Society of Hematology] Press Release

The American Society of Hematology Awards Timothy J. Ley, MD, with 2012 E. Donnall Thomas Lecture and Prize
The American Society of Hematology (ASH) will honor Timothy J. Ley, MD, of Washington University School of Medicine with the 2012 E. Donnall Thomas Lecture and Prize for his groundbreaking work in the genetic analysis of acute myeloid leukemia that has greatly increased the fundamental knowledge regarding the pathogenesis of this disease. [American Society of Hematology] Press Release

Genmab Enters Worldwide Agreement with Janssen for Daratumumab
Genmab A/S announced a global license and development agreement for daratumumab with Janssen Biotech, Inc. (Janssen). Daratumumab is currently in development for multiple myeloma and may have potential in other cancer indications such as acute myeloid leukemia. [Genmab A/S] Press Release

ARIAD Announces Submission of Marketing Authorization Application for Ponatinib to the European Medicines Agency
ARIAD Pharmaceuticals, Inc. announced the submission of a Marketing Authorization Application for its investigational BCR-ABL inhibitor, ponatinib, to the European Medicines Agency. ARIAD is seeking marketing approval in the European Union of ponatinib in adult patients with resistant or intolerant chronic myeloid leukemia and Philadelphia-chromosome positive acute lymphoblastic leukemia. [ARIAD Pharmaceuticals, Inc.] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Stem Cells 2012
October 10-12, 2012
Mumbai, India

NEW 2012 America Society of Hematology (ASH) State of the Art Symposium: Recent Advances in Hematologic Malignancies Including a Special Focus on Thrombosis
October 12-13, 2012
Los Angeles, United States

Visit our events page to see a complete list of events in the hematopoietic community.

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