Hematopoiesis News Volume 3.37 | Sep 18 2012

    0
    19

    Hematopoiesis News 3.37 September 18, 2012
    Hematopoiesis News
         In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
    Cell Therapy News on Facebook  Hematopoiesis News on Twitter

    TOP STORY
    mTOR Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis
    The roles of the unique mechanistic target of rapamycin (mTOR) complexes (mTORCs) in hematopoiesis and leukemogenesis have not been adequately elucidated. These data delineate critical roles for mTORC1 in hematopoietic function and leukemogenesis and inform clinical strategies based on chronic mTORC1 inhibition. [Cell Stem Cell] Abstract

    LIVE Webinar: Faster 7-Day CFU Assays for the Enumeration of Hematopoietic Progenitor Cells in CB. Register now!

    PUBLICATIONS (Ranked by impact factor of the journal)

    LABORATORY RESEARCH

    Monocytes-Macrophages that Express α-Smooth Muscle Actin Preserve Primitive Hematopoietic Cells in the Bone Marrow
    Investigators identified a previously unknown subset of α-smooth muscle actin-positive activated monocytes and macrophages that maintain hematopoietic stem and progenitor cells and protect them from exhaustion during alarm situations. [Nat Immunol] Abstract

    Recombinant IL-7/HGFβ Efficiently Induces Transplantable Murine Hematopoietic Stem Cells
    Researchers used the recombinant single-chain form of a naturally occurring murine hybrid cytokine of IL-7 and the β chain of hepatocyte growth factor (rIL-7/HGFβ) in culture to induce large numbers of hematopoietic stem cells (HSCs) from multiple cell sources, including unseparated BM cells, purified HSCs, CD45- BM cells, and embryonic stem cells. [J Clin Invest] Full Article

    Protein Kinase D-HDAC5 Signaling Regulates Erythropoiesis and Contributes to Erythropoietin Crosstalk with GATA1
    Scientists showed that erythropoietin regulates GATA1 through protein kinase D activation, promoting histone deacetylase 5 (HDAC5) dissociation from GATA1, and subsequent GATA1 acetylation. In ex vivo studies, HDAC5-/- progenitors display enhanced entry into and passage through the erythroid lineage, as well as evidence of erythropoietin-independent differentiation. [Blood] Abstract

    ERG and FLI1 Binding Sites Demarcate Targets for Aberrant Epigenetic Regulation by AML1-ETO in Acute Myeloid Leukemia
    The results highlight the dual importance of ETS factors in t(8;21) leukemogenesis, both as transcriptional regulators of the oncofusion protein itself as well as proteins that facilitate AML1-ETO binding. [Blood] Abstract

    Loss of p53 Exacerbates Multiple Myeloma Phenotype by Facilitating the Reprogramming of Hematopoietic Stem/Progenitor Cells to Malignant Plasma Cells by MafB
    The efficiency of the MafB-induced multiple myeloma reprogramming of normal hematopoietic stem/progenitor cells to terminally differentiated malignant plasma cells is enhanced by p53 deficiency, in analogy to what happens in reprogramming to pluripotency. [Cell Cycle] Abstract

    Notch Signals Contribute to Preserve the Multipotentiality of Human CD34+CD38-CD45RA-CD90+ Hematopoietic Progenitors by Maintaining T Cell Lineage Differentiation Potential
    Researchers identified cord blood CD34+CD38-CD45RA-CD90+ cells as one of the earliest targets of Notch in human hematopoiesis. Upon Notch activation CD34+CD38- cells are blocked in their differentiation at the CD34+CD38-CD45RA-CD90+ stage. Notch signaling is required before lymphoid commitment to preserve T-cell potential of CD34+CD38-CD45RA-CD90+ cells. [Exp Hematol] Abstract

    Identification of the Hemogenic Endothelial Progenitor and Its Direct Precursor in Human Pluripotent Stem Cell Differentiation Cultures
    The authors showed that human hemogenic endothelium progenitors capable of generating definitive hematopoietic cells can be obtained from human pluripotent stem cells and identified precisely by a VE-cadherin+CD73CD235a/CD43 phenotype. [Cell Rep] Abstract

    CLINICAL RESEARCH

    Targeting p53 In Vivo: A First-in-Human Study with p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer
    APR-246 is a novel drug that restores transcriptional activity of unfolded wild-type or mutant p53. APR-246 was administered as a two-hour intravenous infusion once per day for four consecutive days in 22 patients with hematologic malignancies and prostate cancer. [J Clin Oncol] Abstract | Press Release

    Autologous Blood Cell Transplantation versus HLA-Identical Sibling Transplantation for Acute Myeloid Leukemia in First Complete Remission: A Registry Study from the Center for International Blood and Marrow Transplantation Research
    Investigators compared treatment related mortality, relapse, leukemia-free survival, and overall survival for acute myeloid leukemia in first complete remission receiving myeloablative HLA-matched sibling donor versus autologous peripheral blood. [Haematologica] Abstract | Full Article

    T-Cell Depleted Stem-Cell Transplantation for Adults with High-Risk Acute Lymphoblastic Leukemia: Long-Term Survival for Patients in 1st Complete Remission with a Decreased Risk of Graft-versus-Host Disease
    Researchers performed a 56 patient retrospective study to evaluate T-cell depleted allogeneic hematopoietic stem cell transplantation for the treatment of acute lymphoblastic leukemia following myeloablative TBI-based therapy. [Biol Blood Marrow Transplant] Abstract

    StemSpan ACF: The WORLD'S FIRST Plasma Component-Free Hematopoietic Expansion Media. Come learn more.

    REVIEWS

    Hematopoietic Stem Cell Mobilization: Updated Conceptual Renditions
    This review reports some of the more recent advances about hematopoietic stem cell mobilization, with an attempt to reconcile some of the seemingly inconsistent data in mobilization and to interject some commonalities among different mobilization regimes. [Leukemia] Abstract

    Tug of War in the Hematopoietic Stem Cell Niche: Do Myeloma Plasma Cells Compete for the HSC Niche?
    This review provides an overview of the bone marrow microenvironment and its involvement in normal, physiological hematopoietic stem cell (HSC) maintenance and plasma cell growth throughout multiple myeloma disease progression. [Blood Cancer J] Full Article

    Enter Our Contest 
    Hematopoiesis News is giving away a free registration for the 2012 World Stem Cell Summit in West Palm Beach! Chart the future of stem cell science and regenerative medicine at the largest interdisciplinary stem cell conference. Click here to enter.

    INDUSTRY NEWS

    Einstein Researcher Receives $10.8 Million Grant to Study Toxic Blood Reactions Caused by Hemoglobin
    The National Heart, Lung, and Blood Institute, part of the National Institutes of Health, has awarded nearly $11 million to Albert Einstein College of Medicine of Yeshiva University to carry out a five-year multi-institutional study of hemoglobin toxicity that may complicate blood transfusions and reduce the effectiveness of blood substitutes. [Albert Einstein College of Medicine] Press Release

    Emmaus Medical Marks Progression of Phase III Sickle Cell Disease Clinical Trial
    Emmaus Medical, Inc. announced that its U.S. Phase III clinical trial to study L-Glutamine as a treatment for sickle cell disease is nearing target enrollment completion, with investigation now underway at more than 30 clinical study sites throughout the U.S. [Emmaus Medical, Inc.] Press Release | Related Video

    Hybrigenics Starts Phase II Clinical Trial of Inecalcitol in Chronic Lymphocytic Leukemia
    Hybrigenics announced the start of a Phase II clinical trial of oral inecalcitol in patients with chronic lymphocytic leukemia (CLL). It is an open-label trial assessing the safety and potential efficacy of inecalcitol given to CLL patients not yet requiring immuno-chemotherapy but at high risk of disease progression. [Hybrigenics] Press Release

    NIH Fosters High-Risk, High-Reward Innovation at UCSF
    Biomedical researchers at the University of California, San Francisco (UCSF) have won five of 51 prestigious National Institutes of Health (NIH) Director’s New Innovator awards for high-risk, high-reward research, each receiving up to $1.5 million over five years. [The University of California, San Francisco] Press Release

    POLICY NEWS

    National Institutes of Health (United States)

    Food and Drug Administration (United States)
     
    Center for Biologics Evaluation and Research (United States)
     
    European Medicines Agency (European Union)

    Medicines and Healthcare Products Regulatory Agency (United Kingdom)

    Therapeutic Goods Administration (Australia)

    EVENTS
    NEW Fraunhofer Life Science Symposium Leipzig 2012
    November 29-30, 2012
    Leipzig, Germany

    Visit our events page to see a complete list of events in the hematopoietic community.

    JOB OPPORTUNITIES

    Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

    Research Technologist – Media Development (STEMCELL Technologies, Inc.)

    Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

    Scientific Communications and Publishing Coordinator (STEMCELL Technologies, Inc.)

    Postdoctoral Position(s) – Pharmaceutical Immunology/Hematopoietic Cell Development (National Taiwan University)

    Research Associate – Quality Assurance (University of California)

    Postdoctoral Position – Mouse Stem Cell Biology (University of Alabama)

    Postdoctoral Position – Stem Cells and Cancer (Tsinghua University)

    Scientist, Postdoctoral and Research Associate Positions (University of Miami – Sylvester Comprehensive Cancer Center)

    Recruit Top Talent: Reach more than 55,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

    Have we missed an important article or publication in Hematopoiesis News? Click here to submit!

    Comments or Suggestions? Email info@connexoncreative.com with your feedback.

    Learn more about Hematopoiesis Cell News: Archives | Events | Contact Us