LABORATORY RESEARCH Systems-Pharmacology Dissection of a Drug Synergy in Imatinib-Resistant Chronic Myeloid Leukemia Integration of genome- and proteome-wide technologies enabled the elucidation of the mechanism by which a new drug synergy targets the dependency of BCR-ABLT315I chronic myeloid leukemia cells on c-Myc through nonobvious off targets. [Nat Chem Biol] Abstract NOTCH1 Nuclear Interactome Reveals Key Regulators of Its Transcriptional Activity and Oncogenic Function Using immunoaffinity purification, researchers identified NOTCH1 nuclear partners in T cell acute lymphoblastic leukemia cells and showed that NOTCH1 assembles a multifunctional complex containing the transcription coactivator AF4p12, the PBAF nucleosome remodeling complex, and the histone demethylases LSD1 and PHF8 acting through their demethylase activity to promote epigenetic modifications at Notch-target genes. [Mol Cell] Abstract | Graphical Abstract Human Hematopoietic Stem/Progenitor Cells Overexpressing Smad4 Exhibit Impaired Reconstitution Potential In Vivo Findings demonstrated that the Smad signaling circuitry negatively regulates the regeneration capacity of human hematopoietic stem/progenitor cells in vivo. [Blood] Abstract The BAF53a Subunit of SWI/SNF-Like BAF Complexes Is Essential for Hemopoietic Stem Cell Function Scientists provided the first evidence that the actin-related protein BAF53a, a subunit of BAF complexes preferentially expressed in long-term repopulating stem cells, is essential for adult hemopoiesis. [Blood] Abstract Characterization of the Effects of Exercise Training on Hematopoietic Stem Cell Quantity and Function Investigators aimed to determine whether exercise training could expand the bone marrow hematopoietic stem cell (HSC) pool, and influence various aspects of HSC function. [J Appl Physiol] Abstract Clonal Heterogeneity in Cytogenetically Normal Acute Myeloid Leukemia Patients with NPM1 Mutations Data demonstrated that nucleophosmin 1 (NPM1)-mutated cytogenetically normal acute myeloid leukemia originates in an early stem cell with both lymphoid and myeloid differentiation potential. [Leuk Lymphoma] Abstract Compromised Hematopoiesis and Increased DNA Damage following Non-Lethal Ionizing Radiation of a Human Hematopoietic System Reconstituted in Immunodeficient Mice Researchers evaluated the effects of non-lethal doses of X-ray irradiation on human hematopoietic stem and progenitor cells reconstituted in NOD/Shi-scid, IL2Rγnull immunodeficient mice. [Int J Radiat Biol] Abstract Effect of Acute Lung Injury on VLA-4 and CXCR4 Expression in Resident and Circulating Hematopoietic Stem/Progenitor Cells Scientists aimed to determine whether there is a relationship between pulmonary inflammation, expression of VLA-4, LFA-1, L-selectin, CXCR4, and chemotaxis in resident hematopoietic stem/progenitor cells (HSPCs), as well as the level of circulating HSPCs. [Respiration] Abstract CLINICAL RESEARCH Acute Myeloid Leukemia with Translocation (8;16)(p11;p13) and MYST3-CREBBP Rearrangement Harbors a Distinctive MicroRNA Signature Targeting RET Proto-Oncogene Researchers concluded that acute myeloid leukemia with t(8;16)(p11;p13) harbors a specific microRNA signature which is partially epigenetically regulated and which targets RET proto-oncogene. [Leukemia] Abstract Association of Disparities in Known Minor Histocompatibility Antigens with Relapse-Free Survival and Graft-versus-Host-Disease after Allogeneic Stem Cell Transplantation Investigators evaluated whether mismatches in a panel of seventeen minor histocompatibility antigens are associated with clinical outcome after partial T cell-depleted allogeneic stem cell transplantation. [Biol Blood Marrow Transplant] Abstract |