Hematopoiesis News Volume 3.41 | Oct 16 2012

LABORATORY RESEARCH

Perturbation of Fetal Liver Hematopoietic Stem and Progenitor Cell Development by Trisomy 21
Scientists showed that primary trisomy 21 fetal liver hematopoietic stem cells and megakaryocyte-erythroid progenitors are markedly increased, whereas granulocyte-macrophage progenitors are reduced. [Proc Natl Acad Sci USA] Full Article

BCR-ABL1 Kinase Inhibits Uracil DNA Glycosylase UNG2 to Enhance Oxidative DNA Damage and Stimulate Genomic Instability
Researchers report that chronic myeloid leukemia in chronic phase leukemia stem and progenitor cell populations accumulate high amounts of reactive oxygen species, which may result in accumulation of uracil derivatives in genomic DNA. [Leukemia] Abstract

CD34+/CD38- Acute Myelogenous Leukemia Cells Aberrantly Express CD82 which Regulates Adhesion and Survival of Leukemia Stem Cells
To identify molecular targets in leukemia stem cells, investigators compared the protein expression profile of freshly isolated CD34⁺/CD38^– cells with that of CD34⁺/CD38⁺ counterparts from individuals with acute myelogenous leukemia using isobaric tags for relative and absolute quantitation. [Int J Cancer] Abstract

Aging Induced Decline in T-Lymphopoiesis Is Primarily Dependent on Status of Progenitor Niches in the Bone Marrow and Thymus
By grafting young wild-type (WT) bone marrow (BM) progenitors into aged IL-7R-/- hosts, which possess WT-equivalent niches although lympho-hematopoietic progenitor/stem cells are defect, investigators demonstrated that these young BM progenitors exhibited a myeloid skew. [Aging] Full Article

Successful Isolation and Expansion of CMV-Reactive T Cells from G-CSF Mobilized Donors that Retain a Strong Cytotoxic Effector Function
Scientists investigated the use of a small aliquot of a granulocyte-colony stimulating factor (G-CSF) mobilized hematopoietic stem cell transplantation graft to manufacture cytomegalovirus (CMV)-specific T cells. [Br J Haematol] Abstract

Expression and Function of PML-RARA in the Hematopoietic Progenitor Cells of Ctsg-PML-RARA Mice
Scientists showed that both Ctsg, and PML-RARA targeted to the Ctsg locus (in Ctsg-PML-RARA mice), are expressed in the purified Kit⁺Lin^–Sca⁺ cells of these mice and this expression results in biological effects in multi-lineage competitive repopulation assays. [PLoS One] Full Article

Impact of Different Dimethyl Sulphoxide Concentrations on Cell Recovery, Viability and Clonogenic Potential of Cryopreserved Peripheral Blood Hematopoietic Stem and Progenitor Cells
Researchers tested if dimethyl sulphoxide concentration might be reduced without negative impact on cell recovery and clonogenicity of autologous hematopoietic stem/progenitor cells. [Vox Sang] Abstract

CLINICAL RESEARCH

Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Mildly Reduced Renal Function Based on Creatinine Clearance before Transplantation
Researchers retrospectively assessed how mildly reduced renal function as defined based on creatinine clearance rate affects renal comorbidity after allogeneic hematopoietic stem cell transplantation. [Ann Hematol] Abstract

Predictors of Hemoglobin Response to Eculizumab Therapy in Paroxysmal Nocturnal Hemoglobinuria
Thirty patients with paroxysmal nocturnal hemoglobinuria clones were treated with eculizumab and classified as complete responders (4 patients), good partial responders (16) and suboptimal responders (10) over 863 patient-months of treatment. [Eur J Haematol] Abstract

The Terry Fox Foundation Provides $13.4 million for Research into Fighting Cancer with Viruses and Finding Ways to Treat Acute Leukemias
Fundings from the Terry Fox Foundation will support an Ottawa, Ontario-based team conducting research into oncolytic viruses to treat various forms of cancer and a Vancouver, British Columbia-based team exploring why acute forms of leukemia are difficult to treat. [The Terry Fox Foundation] Press Release

Sanofi and Massachusetts General Hospital Launch Oncology Research Collaboration
Sanofi announced a two-year agreement with Massachusetts General Hospital aimed at furthering translational medicine research to develop new treatments for various types of hematological malignancies and solid tumors. [Sanofi Oncology] Press Release

Pharmacyclics® Triggers another Significant Milestone Payment for Phase III Chronic Lymphocytic Leukemia Combination Trial
Pharmacyclics, Inc. announced that the international, randomized phase III clinical trial of ibrutinib in combination with bendamustine and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma has enrolled its fifth patient. The enrollment of the fifth patient has subsequently triggered a third $50 million milestone payment obligation from Janssen Biotech, Inc., worldwide collaborator on ibrutinib in oncology and sponsor of this trial. [Pharmacyclics, Inc.] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Research Associate – Quality Assurance (University of California)

Postdoctoral Position – Mouse Stem Cell Biology (University of Alabama)

Postdoctoral Position – Stem Cells and Cancer (Tsinghua University)

Scientist, Postdoctoral and Research Associate Positions (University of Miami – Sylvester Comprehensive Cancer Center)

Postdoctoral Position – Impact of Inflammation on Hematopoiesis and Cancer (University of Murcia)

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