LABORATORY RESEARCH Meis1 Preserves Hematopoietic Stem Cells in Mice by Limiting Oxidative Stress Using inducible knock-out mice, scientists found that Meis1 is required for the maintenance of hematopoiesis under stress and over long term while steady-state hematopoiesis was sustained in the absence of Meis1. [Blood] Abstract Cell Autonomous and Non-Autonomous Mechanisms Drive Hematopoietic Stem/Progenitor Cell Loss in the Absence of DNA Repair Researchers demonstrated that mice expressing reduced levels of ERCC1-XPF DNA repair endonuclease spontaneously display a progressive decline in the number and function of hematopoietic stem/progenitor cells. [Stem Cells] Abstract Hematopoietic Stem Cell Gene Therapy for the Multisystemic Lysosomal Storage Disorder Cystinosis Using the Ctns-/- murine model for cystinosis, investigators tested the use of hematopoietic stem and progenitor cells genetically modified to express a functional CTNS transgene using a self-inactivating-lentiviral vector. [Mol Ther] Abstract Broad Cross-Presentation of the Hematopoietically Derived PR1 Antigen on Solid Tumors Leads to Susceptibility to PR1-Targeted Immunotherapy The authors recently showed that proteinase 3 (P3) and neutrophil elastase (NE) are taken up and cross-presented by normal and leukemia-derived APCs, and that NE is taken up by breast cancer cells. In this report, they extend their findings to show that P3 and NE are taken up and cross-presented by human solid tumors. [J Immunol] Abstract N-Cadherin+ HSCs in Fetal Liver Exhibit Higher Long-Term Bone Marrow Reconstitution Activity than N-Cadherin– HSCs Scientists investigated the role of N-cadherin in the maintenance of hematopoietic stem cells (HSCs) during fetal liver hematopoiesis. [Biochem Biophys Res Commun] Abstract Pleiotrophin Regulates the Retention and Self-Renewal of Hematopoietic Stem Cells in the Bone Marrow Vascular Niche Investigators examined the role of the heparin-binding growth factor pleiotrophin (PTN) in regulating hematopoietic stem cell (HSC) function in the niche. PTN−/− mice displayed significantly decreased bone marrow HSC content and impaired hematopoietic regeneration following myelosuppression. [Cell Reports] Full Article | Press Release | Graphical Abstract CLINICAL RESEARCH Biallelic ATM Inactivation Significantly Reduces Survival in Patients Treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 Trial Researchers analyzed the ATM gene in 224 patients treated on the Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial with chlorambucil or fludarabine with and without cyclophosphamide. [J Clin Oncol] Abstract Treatment of Relapsed Adult T-Cell Leukemia/Lymphoma after Allogeneic Hematopoietic Stem Cell Transplantation: The Nagasaki Transplant Group Experience Researchers retrospectively analyzed 35 patients who experienced progression of or relapsed persistent adult T-cell leukemia/lymphoma after a first allogeneic hematopoietic stem cell transplantation at three institutions in Nagasaki prefecture between 1997 and 2010. [Blood] Abstract Long-Term Follow-Up of Haploidentical Hematopoietic Stem Cell Transplantation without In Vitro T Cell Depletion for the Treatment of Leukemia: Nine Years of Experience at a Single Center Over the past 9 years, 756 patients underwent haploidentical transplantation using a protocol developed by the authors, which combines granulocyte-colony stimulating factor-primed bone marrow and peripheral blood stem cells without in vitro T cell depletion. [Cancer] Abstract Outcomes of Second Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Acute Lymphoblastic Leukemia Researchers retrospectively analyzed the outcomes of 31 patients with relapsed acute lymphoblastic leukemia after a prior allogeneic hematopoietic stem cell transplantation (allo-SCT), who received a second SCT at their center. [Bone Marrow Transplant] Abstract |