LABORATORY RESEARCH miR-155 Targets Histone Deacetylase 4 (HDAC4) and Impairs Transcriptional Activity of B-Cell Lymphoma 6 (BCL6) in the Eµ-miR-155 Transgenic Mouse Model Researchers provide a mechanistic insight into microRNA (miR)-155-induced leukemogenesis in an ectopic expression of miR-155 mouse model (Eμ-miR-155) through genome-wide transcriptome analysis of naïve B cells and target studies. [Proc Natl Acad Sci USA] Abstract Prostaglandin E2 Increases Hematopoietic Stem Cell Survival and Accelerates Hematopoietic Recovery after Radiation Injury Scientists demonstrated that prostaglandin E2 treatment in naïve mice inhibits apoptosis of hematopoietic stem and progenitor cells without changing their proliferation rate. [Stem Cells] Abstract TiF1-Gamma Plays an Essential Role in Murine Hematopoiesis and Regulates Transcriptional Elongation of Erythroid Genes Previous studies in zebrafish have identified an essential role for the transcriptional intermediary factor TIF1γ in erythropoiesis by regulating the transcription elongation of erythroid genes. To study if TIF1γ plays a similar role in murine erythropoiesis and to assess its function in other blood lineages, researchers generated mouse models with hematopoietic deletion of TIF1γ. [Dev Biol] Abstract 2-(Trimethylammonium)Ethyl (R)-3-Methoxy-3-Oxo-2-Stearamidopropyl Phosphate Promotes Megakaryocytic Differentiation of Myeloid Leukemia Cells and Primary Human CD34+ Hematopoietic Stem Cells The authors showed that 2-(trimethylammonium)ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate, a derivative of an organic chemical identified from a natural product library, promotes highly efficient differentiation of megakaryocytes. [J Tissue Eng Regen Med] Abstract The Effect of Granulocyte Colony Stimulating Factor Receptor Gene Missense Single Nucleotide Polymorphisms on Peripheral Blood Stem Cell Enrichment Researchers asked whether the missense single nucleotide polymorphisms in granulocyte-colony stimulating factor (G-CSF) could affect the response to G-CSF in hematopoietic stem cell transplantation patients and donors. [Cytokine] Abstract CLINICAL RESEARCH High-Dose Vincristine Sulfate Liposome Injection for Advanced, Relapsed, and Refractory Adult Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia Sixty-five adults with Philadelphia chromosome-negative acute lymphoblastic leukemia in second or greater relapse or whose disease had progressed following two or more leukemia therapies were treated in this pivotal phase II, multinational trial. [J Clin Oncol] Abstract Model-Based Decision Rules Reduce the Risk of Molecular Relapse after Cessation of Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid Leukemia Molecular response to imatinib in chronic myeloid leukemia is associated with a biphasic but heterogeneous decline of BCR-ABL transcript levels. The authors analyzed this inter-individual heterogeneity and provide a predictive mathematical model to prognosticate the long-term response and the individual risk of molecular relapse upon treatment cessation. [Blood] Abstract Treosulfan-Thiotepa-Fludarabine Based Conditioning Regimen for Allogeneic Transplantation in Patients with Thalassemia Major: A Single Center Experience from North India Researchers analyzed the safety and efficacy of treosulfan/thiotepa/fludarabine based conditioning regimen for allogeneic stem cell transplantation in thalassemia major patients. [Biol Blood Marrow Transplant] Abstract |