LABORATORY RESEARCH Mesp1 Patterns Mesoderm into Cardiac, Hematopoietic, or Skeletal Myogenic Progenitors in a Context-Dependent Manner To define the early embryonic cell population that responds to Mesp1, researchers performed pulse inductions of gene expression over tight temporal windows following embryonic stem cell differentiation. Remarkably, instead of promoting cardiac differentiation in the initial wave of mesoderm, Mesp1 binds to the Tal1 +40 kb enhancer and generates Flk-1+ precursors expressing Etv2 and Tal1 that undergo hematopoietic differentiation. [Cell Stem Cell] Abstract | Graphical Abstract Chemotherapy-Induced Bone Marrow Nerve Injury Impairs Hematopoietic Regeneration Researchers demonstrated that chemotherapy-induced nerve injury in the bone marrow of mice is a crucial lesion impairing hematopoietic regeneration. [Nat Med] Abstract | Press Release AML1-ETO Mediates Hematopoietic Self-Renewal and Leukemogenesis through a COX/β-Catenin Signaling Pathway The data indicate an important role of a cyclooxygenase (COX)/β-catenin-dependent signaling pathway in tumor initiation, growth and self-renewal, and provide the rationale for testing potential benefits from common COX inhibitors as a part of acute myelogenous leukemia (AML) treatments. [Blood] Abstract Mast Cell-Deficient KitW-sh “Sash” Mutant Mice Display Aberrant Myelopoiesis Leading to the Accumulation of Splenocytes That Act as Myeloid-Derived Suppressor Cells Mast cell-deficient KitW-sh “sash” mice are widely used to investigate mast cell functions. However, mutations of c-Kit also affect additional cells of hematopoietic and nonimmune origin. Researchers demonstrated that KitW-sh causes aberrant extramedullary myelopoiesis characterized by the expansion of immature lineage-negative cells, common myeloid progenitors, and granulocyte/macrophage progenitors in the spleen. [J Immunol] Abstract Ddx46 Is Required for Multi-Lineage Differentiation of Hematopoietic Stem Cells in Zebrafish Results provide the first genetic evidence that zebrafish Ddx46 is required for the multi-lineage differentiation of hematopoietic stem cells during development, through the regulation of specific gene expressions. [Stem Cells Dev] Abstract In Vivo Tracking and Comparison of the Therapeutic Effects of MSCs and HSCs for Liver Injury Mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs) and the combination of both cells were obtained from the bone marrow of male mice expressing enhanced green fluorescent protein and injected into the female mice with or without liver fibrosis. The distribution of the stem cells, survival rates, liver function, hepatocyte regeneration, growth factors and cytokines of the recipient mice were analyzed. [PLoS One] Full Article Quantification and Localization of Erythropoietin-Receptor-Expressing Cells in the Liver of Xenopus laevis Researchers aimed to determine the dynamics of erythropoiesis in the livers of normal and anemic X. laevis by identifying the number and precise location of mature and immature erythrocytes. [Cell Tissue Res] Abstract CLINICAL RESEARCH Serum 2-Hydroxyglutarate Levels Predict Isocitrate Dehydrogenase Mutations and Clinical Outcome in Acute Myeloid Leukemia Scientists studied whether 2-hydroxyglutarate (2HG) measurements in AML patients correlate with IDH mutations, and whether diagnostic or remission 2HG measurements predict survival. [Blood] Abstract Outcomes of Adults with Acute Lymphoblastic Leukemia (ALL) following Relapse Post Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) Researchers retrospectively analyzed outcomes of 123 adult patients with ALL who relapsed after a first HSCT. [Biol Blood Marrow Transplant] Abstract The Kinetics and Apoptotic Profile of Circulating Endothelial Cells in Autologous Hematopoietic Stem Cell Transplantation in Patients with Lymphoproliferative Disorders In neoplastic disorders, endothelial cells take part in tumor progression and also influence the recovery of hematopoiesis after high-dose chemotherapy. Measurements of circulating endothelial cells, their subsets and kinetics were taken in patients with lymphoid malignancies during autologous hematopoietic stem cell transplantation. [Ann Hematol] Abstract |