LABORATORY RESEARCH C/EBPα Is Required for Long-Term Self-Renewal and Lineage Priming of Hematopoietic Stem Cells and for the Maintenance of Epigenetic Configurations in Multipotent Progenitors Researchers report that C/EBPα serves to protect adult hematopoietic stem cells (HSCs) from apoptosis and to maintain their quiescent state. Consequently, deletion of Cebpa is associated with loss of self-renewal and HSC exhaustion. [PLoS Genet] Full Article Highly Active Combination of BRD4 Antagonist and Histone Deacetylase Inhibitor against Human Acute Myeloid Leukemia (AML) Cells Scientists demonstrated the sensitizing effects of the histone hyperacetylation inducing pan-histone deacetylase inhibitor panobinostat on human AML blast progenitor cells to the bromodomain and extra terminal protein antagonist JQ1. [Mol Cancer Ther] Abstract Remodeling of Marrow Hematopoietic Stem and Progenitor Cells by Non-Self ST6Gal-1 Sialyltransferase Scientists showed that extracellular ST6Gal-1 sialyltransferase, originating mostly from the liver and released into circulation, targets marrow hematopoietic stem and progenitor cells (HSPCs) and mediates the formation of cell surface α2,6-linked sialic acids on HSPCs, as assessed by binding to the specific lectins, Sambucus nigra and Polysporus squamosus and confirmed by mass spectrometry. [J Biol Chem] Abstract An Anti-Apoptotic Molecule Anamorsin Is Essential for Both Development and/or Maintenance of Hematopoietic Stem Cells and Microenvironments to Support Fetal Liver Hematopoiesis Investigators characterized the hematopoietic defects in Anamorsin-deficient (AM-/-) fetal livers. The AM-/- fetal liver displayed significantly reduced numbers of c-Kit+ Sca-1+ Lin- cells. [Exp Hematol] Abstract Indirect Immune Recognition of Mouse Embryonic Stem Cell-Derived Hematopoietic Progenitors In Vitro Scientists compared the developmental maturity and immunogenicity of embryonic stem cell (ESC)-derived hematopoietic progenitors generated via two methods: embryoid body formation and culture of ESCs with the OP9 bone marrow stromal cell line. [Exp Hematol] Abstract CLINICAL RESEARCH Teriparatide (PTH 1-34) Treatment Increases Peripheral Hematopoietic Stem Cells in Postmenopausal Women Researchers studied the impact of long-term daily teriparatide (PTH 1-34) treatment on cells of the hematopoietic lineage in postmenopausal women. Twenty-three postmenopausal women at high risk of fracture received teriparatide 20 mcg SC daily for 24 months as part of a prospective longitudinal trial. [J Bone Miner Res] Abstract Achieving Deeper Molecular Response Is Associated with a Better Clinical Outcome in Chronic Myeloid Leukemia Patients on Imatinib Frontline Therapy Investigators evaluated the frequency of complete molecular response in imatinib de novo chronic-phase chronic myeloid leukemia patients, identified baseline and under-treatment predictive factors of complete molecular response in patients achieving complete cytogenetic response and assessed if complete molecular response is associated with a better outcome. [Haematologica] Abstract | Full Article Hematopoietic Stem Cell Transplantation for Severe Sickle Cell Disease in Childhood: A Single Center Experience of 50 Patients Researchers report the outcome of 50 consecutive children with severe sickle cell disease that received hematopoietic stem cell transplantation in their unit between November 1988 and April 2013. [Br J Haematol] Abstract Phase I/II Study of VELCADE®-BEAM (V-BEAM) and Autologous Hematopoietic Stem Cell Transplantation (ASCT) for Relapsed Indolent Non-Hodgkin Lymphoma (NHL), Transformed, or Mantle Cell Lymphoma (MCL) A Phase I/II trial was designed to evaluate the safety and activity of adding bortezomib to standard BEAM (BCNU, etoposide, cytarabine, melphalan) and ASCT. Eligible patients had relapsed/refractory indolent or transformed NHL or MCL that was relapsed/refractory or in first partial or complete remission. [Biol Blood Marrow Transplant] Abstract |