LABORATORY RESEARCH Circulating Hematopoietic Stem and Progenitor Cells Are Myeloid-Biased in Cancer Patients Researchers showed, in detailed studies of the peripheral blood from 133 untreated patients with seven different types of tumors, that the composition of circulating hematopoietic stem and progenitor cells was significantly altered in patients with solid tumors. [Proc Natl Acad Sci USA] Abstract Efficacy against Human Acute Myeloid Leukemia and Myeloablation of Normal Hematopoiesis in a Mouse Model Using Chimeric Antigen Receptor-Modified T Cells Scientists showed that CD123 is a good target for acute myeloid leukemia (AML)-directed chimeric antigen receptor therapy, as its expression increases over time in vivo even in initially CD123dim populations, and that human CD123-redirected T cells eradicate primary AML in immunodeficient mice. [Blood] Abstract Donor Hematopoiesis in Mice Following Total Lymphoid Irradiation Requires Host T Regulatory Cells for Durable Engraftment Total lymphoid irradiation is reported to increase the frequency of regulatory CD4+CD25+FoxP3+ T cells relative to conventional T cells. Barriers to hematopoietic stem cell engraftment following this non-myeloablative conditioning were evaluated. [Blood] Abstract Pten Regulates Homeostasis and Inflammation-Induced Migration of Myelocytes in Zebrafish The expression of hematopoietic marker genes was analyzed via whole mount in situ hybridization assay in ptena and ptenb double mutant zebrafish. The embryonic myelopoiesis was characterized by living imaging and whole mount in situ immunofluorescence with confocal microscopy, as well as cell-specific chemical staining for neutrophils and macrophages. [J Hematol Oncol] Full Article Altered Hematopoietic Stem Cell and Osteoclast Precursor Frequency in Cathepsin K Null Mice Researchers investigated whether genetic ablation of CatK altered the number of hematopoietic stem cells and osteoclast precursor cells using two mouse models: CatK-/- mice and a knock-in mouse model in which the CatK gene is replaced by cre recombinase. [J Cell Biochem] Abstract CLINICAL RESEARCH Pre-Transplant Administration of Imatinib for Allogeneic Hematopoietic Stem Cell Transplantation in Patients with BCR-ABL-Positive Acute Lymphoblastic Leukemia Investigators evaluated the impact of pre-transplant imatinib administration on the outcome of allogeneic hematopoietic stem cell transplantation in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia. [Blood] Abstract Reduced Intensity Conditioning, Combined Transplantation of Haploidentical Hematopoietic Stem Cells and Mesenchymal Stem Cells in Patients with Severe Aplastic Anemia Investigators examined if transplantation of combined haploidentical hematopoietic stem cells and mesenchymal stem cells affected graft failure and graft-versus-host disease in patients with severe aplastic anemia. [PLoS One] Full Article Identification of Hematopoietic Progenitor Cell Donor Characteristics Predicting Successful Mobilization: Results of an Italian Multicenter Study Prolonged stimulation and repeated collections or failure to reach hematopoietic progenitor cell (HPC) target may occur, increasing risks for donors and recipients. Researchers carried out a retrospective multicenter study on healthy donors, to identify donor variables which may correlate with HPC mobilization. [Transfusion] Abstract |