Hematopoiesis News Volume 5.17 | May 6 2014

    0
    31

    Hematopoiesis News 5.17 May 6, 2014

    Hematopoiesis News

         In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
    Cell Therapy News on Facebook  Hematopoiesis News on Twitter

     
    TOP STORY
    The Unfolded Protein Response Governs Integrity of the Hematopoietic Stem-Cell Pool during Stress
    Scientists showed that human hematopoietic stem cells are predisposed to apoptosis through strong activation of the PERK branch of the unfolded protein response after endoplasmic reticulum stress, whereas closely related progenitors exhibit an adaptive response leading to their survival. [Nature] Abstract
    mTeSR(TM)1: Most Published Feeder-Free hPSC Maintenance Medium. Click to View Top Applications

     
    PUBLICATIONS (Ranked by impact factor of the journal)
    LABORATORY RESEARCH

    Rare and Low-Frequency Coding Variants in CXCR2 and Other Genes Are Associated with Hematological Traits
    To test the effects of rare and low-frequency coding variants on hematological traits, researchers analyzed hemoglobin concentration, hematocrit levels, white blood cell counts and platelet counts in 31,340 individuals genotyped on an exome array. [Nat Med] Abstract

    Bone Marrow-on-a-Chip Replicates Hematopoietic Niche Physiology In Vitro
    Scientists describe a method for fabricating ‘bone marrow-on-a-chip’ that permits culture of living marrow with a functional hematopoietic niche in vitro by first engineering new bone in vivo, removing it whole and perfusing it with culture medium in a microfluidic device. [Nat Method] Abstract

    Loss of β-Catenin Triggers Oxidative Stress and Impairs Hematopoietic Regeneration
    Using Wnt reporter mice, scientists showed that radiation triggers activation of Wnt signaling in hematopoietic stem and progenitor cells. β-Catenin-deficient mice, which lack the ability to activate canonical Wnt signaling, exhibited impaired hematopoietic stem cell regeneration and bone marrow recovery after radiation. [Genes Dev] Abstract | Press Release

    Functional and Molecular Features of the Calmodulin-Interacting Protein IQCG Required for Hematopoiesis in Zebrafish
    Investigators used zebrafish to investigate the role of iqcg in hematopoietic development, and find that the numbers of hematopoietic stem cells and multilineage-differentiated cells are reduced in iqcg-deficient embryos. [Nat Commun] Abstract

    Post-Transcriptional Regulation of c-Myc Expression in Adult Murine HSCs during Homeostasis and Interferon-α Induced Stress Response
    Scientists showed that hematopoietic stem cells (HSCs) and more committed progenitors express similar levels of c-myc transcripts. Using knock-in mice expressing a functional eGFP-c-Myc fusion protein under control of the endogenous c-myc locus, c-Myc protein levels were assessed. [Blood] Abstract

    Integrated Genetic Approaches Identify the Molecular Mechanisms of Sox4 in Early B Cell Development: Intricate Roles for RAG1/2 and CK1ϵ
    The authors used integrated genetic approaches and systematically determined the role of Sox4 and the underlying molecular mechanisms in early B cell development. They found that Sox4 coordinates multilevel controls in the differentiation of early-stage B cells. [Blood] Abstract

    CLINICAL RESEARCH

    Sensitivity of Hematological Malignancies to Graft-versus-Host Effects: An EBMT Megafile Analysis
    In chronic myeloid leukemia (CML), the relapse risk declined clearly and proportionally to severity of acute and chronic graft-versus-host disease (GvHD). Acute lymphoblastic leukemia and BCR-ABL negative myeloproliferative neoplasias were comparably sensitive to GvHD as CML, whereas myelodysplastic syndromes and lymphoproliferative disorders showed intermediate sensitivity. [Leukemia] Abstract

    Allogeneic Stem Cell Transplantation for Mantle Cell Lymphoma – Final Report from the Prospective Trials of the East German Study Group Hematology/Oncology (OSHO)
    Investigators evaluated allogeneic stem cell transplantation (alloSCT) as consolidation for patients with mantle cell lymphoma. Thirty-three of 39 patients underwent alloSCT after myeloablative or toxicity-reduced conditioning. [Ann Hematol] Abstract

    Take the "if" out of "diff": Reduce variability when differentiating to hematopoietic cells

     
    REVIEWS
    Possible Implication of Bacterial Infection in Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation
    The authors review the literature addressing the interactions of bacterial infections and graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. [Front Oncol] Abstract

    Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

    Stem Cells and Regen Med Asia 2014

     
    INDUSTRY NEWS
    Actinium Announces Start of Collaboration to Manufacture Iomabâ„¢-B for Phase III Clinical Trial and Commercialization
    Actinium Pharmaceuticals, Inc. announced that it made further steps towards centralized current good manufacturing practice (cGMP) manufacturing of its lead drug candidate Iomabâ„¢-B. Iomabâ„¢-B is being developed to enable bone marrow transplants in patients affected by relapsed and refractory acute myeloid leukemia. [Actinium Pharmaceuticals, Inc.] Press Release

    PIXUVRI® Launched in UK for Adult Patients with Multiply Relapsed or Refractory Aggressive B-Cell Non-Hodgkin Lymphoma
    Cell Therapeutics, Inc. announced the launch of PIXUVRI® (pixantrone), the first new treatment for adult patients in the United Kingdom (UK) with multiply relapsed or refractory aggressive B-cell non-Hodgkin lymphoma. [Cell Therapeutics, Inc.] Press Release

    From our sponsor:
    View immunology lectures, protocols and other resources on the Human Immunology Portal.

     
    POLICY NEWS
    National Institutes of Health (United States)

    Food and Drug Administration (United States)

    Center for Biologics Evaluation and Research (United States)

    European Medicines Agency (European Union)

    Medicines and Healthcare Products Regulatory Agency (United Kingdom)

    Therapeutic Goods Administration (Australia)

     
    EVENTS
    NEW Florida Association of Blood Banks Pre-Meeting Symposium
    June 4, 2014
    Sarasota, United States

    Visit our events page to see a complete list of events in the hematopoiesis research community.

     
    JOB OPPORTUNITIES
    NEW Postdoctoral Researcher – Cancer Genomics (University of Chicago)

    NEW Research Technologist – hPSC (STEMCELL Technologies Inc.)

    Postdoctoral Fellow in Cardiovascular Immunology / Hematology (Massachusetts General Hospital)

    Postdoctoral Associate – Hematopoietic Differentiation (Northwestern University Feinberg School of Medicine)

    Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (Nationwide Children’s Hospital)

    Postdoctoral Position – Development of Novel Treatment for Mixed Lineage Leukemia (Oslo University Hospital)

    Research Associate – Hematology/Oncology (University of Chicago)

    Postdoctoral Position – Immunotherapies for Cancer Based on Genetic Engineered T Lymphocytes and/or Hematopoietic Stem Cells (Roswell Park Cancer Institute)

    Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (The Icahn School of Medicine at Mount Sinai)

    Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

    Research Associate – Cell Separation (STEMCELL Technologies Inc.)

    Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

    Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)


    Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

     

    Have we missed an important article or publication in Hematopoiesis News? Click here to submit!

    Comments or suggestions? Submit your feedback here

    Learn more about Hematopoiesis News: Archives | Events | Contact Us