Direct Induction of Hematoendothelial Programs in Human Pluripotent Stem Cells by Transcriptional Regulators By screening the effect of 27 candidate factors, researchers reveal two groups of transcriptional regulators capable of inducing distinct hematopoietic programs from human pluripotent stem cells: pan-myeloid (ETV2 and GATA2) and erythro-megakaryocytic (GATA2 and TAL1). [Nat Commun] Abstract | Press Release Tif1γ Regulates the TGF-β1 Receptor and Promotes Physiological Aging of Hematopoietic Stem Cells Researchers report that four month old mice deleted for transcription intermediary factor 1γ (Tif1γ) in hematopoietic stem cells developed an accelerated aging phenotype. [Proc Natl Acad Sci USA] Abstract Dual Mechanisms by Which miR-125b Represses IRF4 to Induce Myeloid and B Cell Leukemias Scientists demonstrate that microRNA-125b (miR-125b) induces myeloid leukemia by enhancing myeloid progenitor output from stem cells as well as inducing immortality, self-renewal, and tumorigenesis in myeloid progenitors. [Blood] Abstract Ncor2 Is Required for Hematopoietic Stem Cell Emergence by Inhibiting Fos Signaling in Zebrafish Scientists show that, in zebrafish, nuclear receptor co-repressor-2 (ncor2) is required for hematopoietic stem cell development by repressing fos-vegfd signaling. [Blood] Abstract A Loss of Function Screen of Identified Genome-Wide Association Study Loci Reveals New Genes Controlling Hematopoiesis Using the from-genome wide association studies (GWAS)-to-function strategy scientists not only identified a series of genes that represent novel regulators of thrombopoiesis and hematopoiesis, but this work also represents, to their knowledge, the first example of a functional genetic screening strategy that is a critical step toward obtaining biologically relevant functional data from GWA study for blood cell traits. [PLoS Genet] Full Article Sox4/Tcf7l1 Axis Promotes Progression of BCR-ABL+ Acute Lymphoblastic Leukemia To systematically study the function of Sox4 in acute lymphoblastic leukemia, investigators established a genetically defined mouse leukemia model by transforming progenitor B cells carrying a floxed Sox4 allele and inducing deletion of the allele by the self-excising Cre recombinase. [Haematologica] Abstract | Full Article CLINICAL RESEARCH Randomized, Phase II Trial Comparing Low-Dose Cytarabine with or without Volasertib in AML Patients Not Suitable for Intensive Induction Therapy Eighty-seven patients received low-dose cytarabine (LDAC) subcutaneously days 1-10 or LDAC + volasertib intravenously days 1 + 15, every four weeks. Response rate was higher for LDAC + volasertib versus LDAC. [Blood] Abstract | Press Release Outcomes after Hematopoietic Stem Cell Transplant for Children with I-Cell Disease Although hematopoietic stem cell transplant (HSCT) has been used to successfully treat some lysosomal storage diseases, there have been only two case reports in the use of HSCT to treat mucolipidosis type II (MLII) or I-cell disease. Investigators describe the combined international experience in the use of HSCT for MLII in 22 patients. [Biol Blood Marrow Transplant] Abstract Outcome of Patients with HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma after SCT: A Retrospective Study by the EBMT LWP Experience with allo-SCT for adult T-cell leukemia/lymphoma (ATL) appears encouraging but is limited to Japanese series. Researchers indicate that allo-SCT but not auto-SCT may salvage a subset of ATL patients, supporting the existence of graft vs ATL effect also in non-Japanese patients. [Bone Marrow Transplant] Abstract Impact of HLA Allele Mismatch on the Clinical Outcome in Serologically Matched Related Hematopoietic SCT To clarify the importance of HLA allele mismatch in the GvH direction in related hematopoietic SCT, researchers retrospectively evaluated 2377 patients who received stem cells from an HLA serologically matched related donor in the GvH direction using the database of the Japan Society for Hematopoietic Cell Transplantation. [Bone Marrow Transplant] Abstract |