Seamless Gene Correction of β-Thalassemia Mutations in Patient-Specific iPSCs Using CRISPR/Cas9 and piggyBac Investigators used the latest gene-editing tool, CRISPR/Cas9 technology, combined with the piggyBac transposon to efficiently correct the human hemoglobin beta mutations in patient-derived induced pluripotent stem cells (iPSCs) without leaving any residual footprint. [Genome Res] Abstract | Press Release D-Cyclins Repress Apoptosis in Hematopoietic Cells by Controlling Death Receptor Fas and Its Ligand FasL The authors report that D-cyclins perform a rate-limiting antiapoptotic function in vivo. They found that acute shutdown of all three D-cyclins in bone marrow of adult mice resulted in massive apoptosis of all hematopoietic cell types. [Dev Cell] Abstract | Graphical Abstract Downregulation of Prdm16 mRNA Expression Is a Specific Mechanism to Avoid Leukemogenesis during HOXB4-Mediated HSC Expansion In Vivo To gain further insight into the molecular events underlying HOXB4-mediated hematopoietic stem cell (HSC) expansion, investigators analyzed gene expression changes at multiple time points in Lin–Sca1+c-kit+ cells from mice transplanted with bone marrow cells transduced with a MSCV-HOXB4-ires-YFP vector. [Blood] Abstract Dynamics of Leukemia Stem-Like Cells Extinction in Acute Promyelocytic Leukemia Researchers investigated the dynamics of acute promyelocytic leukemia before and during therapy with regard to disease initiation, progression and therapeutic response. [Cancer Res] Abstract Type II Interferon Promotes Differentiation of Myeloid-Biased Hematopoietic Stem Cells Researchers report that type II interferon signaling is required, both at baseline and during an animal model of LCMV infection, to maintain normal myeloid development. [Stem Cells] Abstract Rictor Is Required for Early B Cell Development in Bone Marrow Scientists demonstrate that the deletion of Rictor induced an aberrant increase in the FoxO1 and Rag-1 proteins in bone marrow (BM) B cells and that this increase was accompanied by a significant decrease in the abundance of B cells in the peripheral blood and the spleen, suggesting impaired development of early B cells in adult mouse BM. [PLoS One] Full Article Identification of Heme Oxygenase 1 (HO-1) as a Novel Negative Regulator of Mobilization of Hematopoietic Stem/Progenitor Cells Researchers demonstrate that HO-1 plays an important and heretofore unrecognized role in retention of hematopoietic stem/progenitor cells (HSPCs) in bone marrow (BM) niches by modulating negatively activation of mobilization promoting complement cascade, maintaining stromal derived factor-1 (SDF-1) level in the BM microenvironment and attenuating chemotactic responsiveness of HSPCs to SDF-1 and sphingosine-1 phosphate gradients in peripheral blood. [Stem Cell Rev] Abstract | Full Article CLINICAL RESEARCH Transplantation Outcomes for Severe Combined Immunodeficiency, 2000-2009 The Primary Immune Deficiency Treatment Consortium was formed to analyze the results of hematopoietic-cell transplantation in children with severe combined immunodeficiency (SCID) and other primary immunodeficiencies. Researchers collected data retrospectively from 240 infants with SCID who had received transplants at 25 centers during a ten-year period. [N Engl J Med] Abstract | Press Release Autologous Hematopoietic Stem Cell Transplantation in Neuromyelitis Optica: A Registry Study of the EBMT Autoimmune Diseases Working Party The European Group for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party conducted a retrospective survey to analyze disease outcome following autologous stem cell transplantation. [Mult Scler J] Abstract |