Hematopoiesis News Volume 5.32 | Aug 26 2014

Runx1 Is Required for Progression of CD41⁺ Embryonic Precursors into HSCs but Not Prior to This
Scientists report that Runx1 deficiency does not preclude formation of VE-cad⁺CD45⁻CD41⁺ cells, which are phenotypically equivalent to precursors of definitive hematopoietic stem cells (HSCs) but blocks transition to the subsequent CD45⁺ stage. [Development] Full Article

IL-33-Induced Hematopoietic Stem and Progenitor Cell Mobilization Depends upon CCR2
Researchers analyzed the in vivo effect of IL-33 administration. IL-33 markedly promoted myelopoiesis in the bone marrow and myeloid cell emigration. [J Immunol] Abstract

The Effects of 1,25-Dihydroxyvitamin D₃ on In Vitro Human NK Cell Development from Hematopoietic Stem Cells
1,25-Dihydroxyvitamin D₃ strongly induced hematopoietic stem cells to differentiate along a myeloid pathway, giving rise to CD14⁺ cells. [J Immunol] Abstract

RIP3 Is Downregulated in Human Myeloid Leukemia Cells and Modulates Apoptosis and Caspase-Mediated p65/RelA Cleavage
Researchers analyzed the expression of receptor-interacting protein kinase (RIP)1 and RIP3 in CD34⁺ leukemia cells from a cohort of patients with acute myeloid leukemia (AML) and CD34⁺ cells from healthy donors. RIP3 expression was significantly reduced in most AML samples, whereas the expression of RIP1 did not differ significantly. [Cell Death Dis] Full Article

The Corepressor Tle4 Is a Novel Regulator of Murine Hematopoiesis and Bone Development
Tle4 deficient hematopoietic stem cells are intrinsically defective in B lymphopoiesis and exhaust upon stress, such as serial transplantation. In the absence of Tle4 there is a profound decrease in bone mineralization. In addition, Tle4 knockout stromal cells are defective at maintaining wild-type hematopoietic stem cell function in vitro. [PLoS One] Full Article

CLINICAL RESEARCH

Controlled Trial of Transfusions for Silent Cerebral Infarcts in Sickle Cell Anemia
Silent cerebral infarcts are the most common neurologic injury in children with sickle cell anemia and are associated with the recurrence of an infarct (stroke or silent cerebral infarct). Scientists tested the hypothesis that the incidence of the recurrence of an infarct would be lower among children who underwent regular blood-transfusion therapy than among those who received standard care. [N Engl J Med] Abstract | Press Release

Good Outcome of Haploidentical Hematopoietic SCT as a Salvage Therapy in Children and Adolescents with Acquired Severe Aplastic Anemia
A total of 17 children and adolescents with severe aplastic anemia underwent haploidentical hematopoietic SCT. The conditioning regimen consisted of BU, fludarabine, CY and anti-thymocyte globulin. [Bone Marrow Transplant] Abstract

Early CMV Replication and Subsequent Chronic GvHD Have a Significant Anti-Leukemic Effect after Allogeneic HSCT in Acute Myeloid Leukemia
Univariate analysis revealed that the factors associated with a reduction in the 5-year cumulative incidence of relapse included the first complete remission status at allogeneic hematopoietic stem cell transplantation (HSCT), non-adverse cytogenetics and molecular abnormalities, pre-transplant serum ferritin level <1,400 mg/dl, chronic graft-versus-host disease (GvHD), and early cytomegalovirus replication. [Ann Hematol] Abstract

Pro-inflammatory Cytokines: Emerging Players Regulating HSC Function in Normal and Diseased Hematopoiesis
The authors highlight key advances demonstrating the impact of pro-inflammatory cytokines on the biology of hematopoietic stem cells (HSCs) and the bone marrow niche, and address ongoing questions regarding their role in normal and pathogenic hematopoiesis. [Exp Cell Res] Abstract

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Cancer Genetics, Inc. and Leading Pathologist from Keck Medicine of USC Collaborate to Evaluate and Optimize Genomic Panel for Lymphoma
Cancer Genetics, Inc. and Keck Medicine of the University of Southern California (USC) pathologist Imran Siddiqi, M.D., Ph.D., announced that they have entered into a collaboration to identify and evaluate genomic markers for the prognosis of diffuse large B-cell lymphoma. [Cancer Genetics, Inc.] Press Release

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NEW Postdoctoral Fellowship – Cancer Biology (University of California – San Francisco)

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